Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations [0]
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- Product number
- AF2619 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse Klotho beta Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects mouse Klotho beta in direct ELISAs and Western blots. In these formats, approximately 5% cross-reactivity with recombinant mouse Klotho is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
NP_112457
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Fusion of fibroblast growth factor 21 to a thermally responsive biopolymer forms an injectable depot with sustained anti-diabetic action.
FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms.
Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine.
FGF21 promotes metabolic homeostasis via white adipose and leptin in mice.
Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor β-Klotho.
Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate.
Metalloproteinase-mediated Shedding of Integrin β2 promotes macrophage efflux from inflammatory sites.
Different roles of N- and C- termini in the functional activity of FGF21.
Gilroy CA, Roberts S, Chilkoti A
Journal of controlled release : official journal of the Controlled Release Society 2018 May 10;277:154-164
Journal of controlled release : official journal of the Controlled Release Society 2018 May 10;277:154-164
FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms.
BonDurant LD, Ameka M, Naber MC, Markan KR, Idiga SO, Acevedo MR, Walsh SA, Ornitz DM, Potthoff MJ
Cell metabolism 2017 Apr 4;25(4):935-944.e4
Cell metabolism 2017 Apr 4;25(4):935-944.e4
Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine.
Keipert S, Ost M, Johann K, Imber F, Jastroch M, van Schothorst EM, Keijer J, Klaus S
American journal of physiology. Endocrinology and metabolism 2014 Mar 1;306(5):E469-82
American journal of physiology. Endocrinology and metabolism 2014 Mar 1;306(5):E469-82
FGF21 promotes metabolic homeostasis via white adipose and leptin in mice.
Véniant MM, Hale C, Helmering J, Chen MM, Stanislaus S, Busby J, Vonderfecht S, Xu J, Lloyd DJ
PloS one 2012;7(7):e40164
PloS one 2012;7(7):e40164
Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor β-Klotho.
Fu T, Choi SE, Kim DH, Seok S, Suino-Powell KM, Xu HE, Kemper JK
Proceedings of the National Academy of Sciences of the United States of America 2012 Oct 2;109(40):16137-42
Proceedings of the National Academy of Sciences of the United States of America 2012 Oct 2;109(40):16137-42
Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate.
Wu S, Levenson A, Kharitonenkov A, De Luca F
The Journal of biological chemistry 2012 Jul 27;287(31):26060-7
The Journal of biological chemistry 2012 Jul 27;287(31):26060-7
Metalloproteinase-mediated Shedding of Integrin β2 promotes macrophage efflux from inflammatory sites.
Gomez IG, Tang J, Wilson CL, Yan W, Heinecke JW, Harlan JM, Raines EW
The Journal of biological chemistry 2012 Feb 10;287(7):4581-9
The Journal of biological chemistry 2012 Feb 10;287(7):4581-9
Different roles of N- and C- termini in the functional activity of FGF21.
Micanovic R, Raches DW, Dunbar JD, Driver DA, Bina HA, Dickinson CD, Kharitonenkov A
Journal of cellular physiology 2009 May;219(2):227-34
Journal of cellular physiology 2009 May;219(2):227-34
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