Antibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Western blot [1]
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Validation data
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- Product number
- PA5-47714 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- NRXN3 Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full-length protein
- Description
- In direct ELISAs, approximately 10% cross-reactivity with recombinant human Neurexin 1 beta is observed and less than 5% cross-reactivity recombinant rat (rr) Neurexin 1 alpha and rrNeurexin 2 beta is observed.
- Concentration
- 0.2 mg/mL
Submitted references Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid.
Lleó A, Núñez-Llaves R, Alcolea D, Chiva C, Balateu-Paños D, Colom-Cadena M, Gomez-Giro G, Muñoz L, Querol-Vilaseca M, Pegueroles J, Rami L, Lladó A, Molinuevo JL, Tainta M, Clarimón J, Spires-Jones T, Blesa R, Fortea J, Martínez-Lage P, Sánchez-Valle R, Sabidó E, Bayés À, Belbin O
Molecular & cellular proteomics : MCP 2019 Mar;18(3):546-560
Molecular & cellular proteomics : MCP 2019 Mar;18(3):546-560
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Western blot analysis of NRXN3 in mouse brain tissue and SH‚SY5Y human neuroblastoma cell line. Samples were incubated in NRXN3 polyclonal antibody (Product # PA5-47714) using a dilution of 1 µg/mL followed by a HRP-conjugated Anti-Sheep IgG secondary antibody. A specific band was detected for Neurexin 3/NRXN3 at approximately 160-170 kDa (as indicated). This experiment was conducted under reducing conditions.