HPA023873

antibody from Atlas Antibodies

Targeting: C9orf72 DENND9, DENNL72, MGC23980

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA023873

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA023873, RRID:AB_1845834

Product name

Anti-C9orf72

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human C9orf72, Gene description: chromosome 9 open reading frame 72, Alternative Gene Names: MGC23980, Validated applications: IHC, Uniprot ID: Q96LT7, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.2 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features

Lorenzini I, Alsop E, Levy J, Gittings L, Lall D, Rabichow B, Moore S, Pevey R, Bustos L, Burciu C, Bhatia D, Singer M, Saul J, McQuade A, Tzioras M, Mota T, Logemann A, Rose J, Almeida S, Gao F, Marks M, Donnelly C, Hutchins E, Hung S, Ichida J, Bowser R, Spires-Jones T, Blurton-Jones M, Gendron T, Baloh R, Van Keuren-Jensen K, Sattler R
Frontiers in Cellular Neuroscience 2023;17

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Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins.

Abo-Rady M, Kalmbach N, Pal A, Schludi C, Janosch A, Richter T, Freitag P, Bickle M, Kahlert AK, Petri S, Stefanov S, Glass H, Staege S, Just W, Bhatnagar R, Edbauer D, Hermann A, Wegner F, Sterneckert JL
Stem cell reports 2020 Mar 10;14(3):390-405

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Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons

Shi Y, Lin S, Staats K, Li Y, Chang W, Hung S, Hendricks E, Linares G, Wang Y, Son E, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan M, Ge B, Koutsodendris N, Sandor K, Komberg J, Vangoor V, Senthilkumar K, Hennes V, Seah C, Nelson A, Cheng T, Lee S, August P, Chen J, Wisniewski N, Hanson-Smith V, Belgard T, Zhang A, Coba M, Grunseich C, Ward M, van den Berg L, Pasterkamp R, Trotti D, Zlokovic B, Ichida J
Nature Medicine 2018;24(3):313-325

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C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons

Sivadasan R, Hornburg D, Drepper C, Frank N, Jablonka S, Hansel A, Lojewski X, Sterneckert J, Hermann A, Shaw P, Ince P, Mann M, Meissner F, Sendtner M
Nature Neuroscience 2016;19(12):1610-1618

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Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes

Busch J, Unger T, Jain N, Skrinak R, Charan R, Chen-Plotkin A
Human Molecular Genetics 2016

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Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death

Wen X, Tan W, Westergard T, Krishnamurthy K, Markandaiah S, Shi Y, Lin S, Shneider N, Monaghan J, Pandey U, Pasinelli P, Ichida J, Trotti D
Neuron 2014;84(6):1213-1225

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Dystrophic neurites express C9orf72 in Alzheimer's disease brains

Satoh J, Tabunoki H, Ishida T, Saito Y, Arima K
Alzheimer's Research & Therapy 2012;4(4)

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Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations

Snowden J, Rollinson S, Thompson J, Harris J, Stopford C, Richardson A, Jones M, Gerhard A, Davidson Y, Robinson A, Gibbons L, Hu Q, DuPlessis D, Neary D, Mann D, Pickering-Brown S
Brain 2012;135(3):693-708

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Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion

Brettschneider J, Van Deerlin V, Robinson J, Kwong L, Lee E, Ali Y, Safren N, Monteiro M, Toledo J, Elman L, McCluskey L, Irwin D, Grossman M, Molina-Porcel L, Lee V, Trojanowski J
Acta Neuropathologica 2012;123(6):825-839