66230-1-Ig

antibody from Proteintech Group

Targeting: UCHL1 PARK5, PGP9.5, Uch-L1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66230-1-Ig

Provider

Proteintech Group

Product name

UCHL1/PGP9.5 antibody

Antibody type

Monoclonal

Description

UCHL1/PGP9.5 antibody (Cat. #66230-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, pig, rat and has been validated for the following applications: IF, IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat, Porcine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1C9E11

Vial size

20ul, 150ul

References

Submitted references

Reliable repurposing of the antibody interactome inside the cell.

O'Shea CM, Shahzad R, Aghasoleimani K, Newman S, Panmanee J, Schalkwyk LC, Brooke GN, Benson FE, Trimmer JS, Bosco DA, Fujisawa T, Ichijo H, Cashman NR, Engel S, Wright GSA
Nature communications 2026 Jan 31;17(1)

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Deubiquitinating Enzyme UCHL1 Modulates FHL2 to Block Ferroptosis and Counteract CD8 (+) T Cell Anti-Tumour Immunity in Lung Adenocarcinoma.

Chen X, Li J, Tang B, Wang X, Huang Y
Immunology 2026 Feb;177(2):384-397

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Deubiquitinase UCH-L1 confers paclitaxel resistance via stabilizing PKM2 to promote glycolysis in triple-negative breast cancer.

Chen X, Zhou X, Meng Y, Zhou Y, Zhang W, Yin L, Shen Y, Zhong J, Zhang T, Zu X
Cell death & disease 2026 Feb 25;17(1)

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Genome-wide landscape of miRNA-mRNA-lncRNA-circRNA ceRNA network in Nanos2 deficient mice.

Li H, Li Y, Wang Y, Liu L, Cui J, Zhang M, Yan Y
PloS one 2025;20(6):e0325260

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Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma.

Zhang S, Jiang L, Cai S, Weng Z, Zhu Y, Cai ZW, Li H, Li Q, Hu LP, Yao HF, Hua R, Zhao Y, Li D, Yang XM, Zhang JF, Jiang SH
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e11726

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ITGA5-expressing tumor cells interact with Schwann cells to drive nerve growth factor-mediated immunosuppression of NK cells.

Liu Y, Han G, Feng K, Lin X, Zhong W, Liu Y, Wang C, Zhang C, Liu X
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Nov 5;33(11):5591-5610

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Single-Cell RNA Sequencing Reveals an Atlas of Meihua Pig Testis Cells.

Zhang M, Yan Y, Peng G, Gao S, Li H, Li Y
Animals : an open access journal from MDPI 2025 Mar 5;15(5)

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NEAT1 promotes the perineural invasion of pancreatic cancer via the E2F1/GDNF axis.

Gu J, Wang Q, Mo J, Qin T, Qian W, Duan W, Han L, Wang Z, Ma Q, Ma J
Cancer letters 2025 Mar 31;613:217497

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Carbon monoxide produced by HO-1 upregulation is the main factor behind the abnormal motility seen in experimental ulcerative colitis in mice.

Zhao M, Lei Y, Wang M, Chen Y, Hou S, Dai X, Gao D, Liu Y, Mazet B, Sha L
American journal of physiology. Gastrointestinal and liver physiology 2025 Mar 1;328(3):G311-G322

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Metabolic reprogramming in astrocytes prevents neuronal death through a UCHL1/PFKFB3/H4K8la positive feedback loop.

Xiong J, Ge X, Pan D, Zhu Y, Zhou Y, Gao Y, Wang H, Wang X, Gu Y, Ye W, Teng H, Zhou X, Wang Z, Liu W, Cai W
Cell death and differentiation 2025 Jul;32(7):1214-1230

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Macrophages excite muscle spindles with glutamate to bolster locomotion.

Yan Y, Antolin N, Zhou L, Xu L, Vargas IL, Gomez CD, Kong G, Palmisano I, Yang Y, Chadwick J, Müller F, Bull AMJ, Lo Celso C, Primiano G, Servidei S, Perrier JF, Bellardita C, Di Giovanni S
Nature 2025 Jan;637(8046):698-707

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DREADDs-Based Chemogenetics Induced Slow Transit Constipation via Inhibition of Enteric Neurons.

Lu XY, Wen YX, Jiang N, Zhou SQ, Yang T, Shi LL, Guo HM, Zhang W, Zhang QP, Zhang NN
Journal of digestive diseases 2025 Jan-Feb;26(1-2):62-73

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Deubiquitinating enzyme UCHL1 stabilizes CAV1 to inhibit ferroptosis and enhance docetaxel resistance in nasopharyngeal carcinoma.

Ye Y, Wang P, Wu D, Tang F, Shen N, Hou G
Anti-cancer drugs 2025 Aug 1;36(7):539-548

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Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway.

Chen KD, Wang KL, Chen C, Zhu YJ, Tang WW, Wang YJ, Chen ZP, He LH, Chen YG, Zhang W
World journal of gastroenterology 2024 May 28;30(20):2709-2725

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Ursolic acid alleviates paclitaxel-induced peripheral neuropathy through PPARγ activation.

Yang Y, He Z, Wu S
Toxicology and applied pharmacology 2024 Mar;484:116883

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UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5.

Li J, Liang Y, Zhou S, Chen J, Wu C
Breast cancer research : BCR 2024 Mar 11;26(1):44

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Gingival proteomics reveals the role of TGF beta and YAP/TAZ signaling in Raine syndrome fibrosis.

Costa CRR, Chalgoumi R, Baker A, Guillou C, Yamaguti PM, Simancas Escorcia V, Abbad L, Amorin BR, de Lima CL, Cannaya V, Benassarou M, Berdal A, Chatziantoniou C, Cases O, Cosette P, Kozyraki R, Acevedo AC
Scientific reports 2024 Apr 25;14(1):9497

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The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems.

Decourt C, Schaeffer J, Blot B, Paccard A, Excoffier B, Pende M, Nawabi H, Belin S
PLoS biology 2023 Apr;21(4):e3002044

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Isolation and in vitro expansion of porcine spermatogonial stem cells.

Zhao X, Wan W, Li B, Zhang X, Zhang M, Wu Z, Yang H
Reproduction in domestic animals = Zuchthygiene 2022 Feb;57(2):210-220

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Oxaliplatin-induced peripheral neuropathy can be minimized by pressurized regional intravascular delivery in an orthotopic murine pancreatic cancer model.

Shankara Narayanan JSN, Frizzi K, Erdem S, Ray P, Jaroch D, Cox B, Katz S, Vicente D, White R
Discover oncology 2022 Apr 6;13(1):21

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UCH-L1-mediated Down-regulation of Estrogen Receptor α Contributes to Insensitivity to Endocrine Therapy for Breast Cancer.

Chen XS, Wang KS, Guo W, Li LY, Yu P, Sun XY, Wang HY, Guan YD, Tao YG, Ding BN, Yin MZ, Ren XC, Zhang Y, Chen CS, Ye YC, Yang JM, Cheng Y
Theranostics 2020;10(4):1833-1848

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A proteomic approach reveals the differential protein expression in Drosophila melanogaster treated with red ginseng extract (Panax ginseng).

Liu QX, Zhang W, Wang J, Hou W, Wang YP
Journal of ginseng research 2018 Jul;42(3):343-351

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Role of the Ubiquitin C-Terminal Hydrolase L1-Modulated Ubiquitin Proteasome System in Auditory Cortex Senescence.

Zhang Y, Huang X, Zhao XY, Hu YJ, Sun HY, Kong WJ
ORL; journal for oto-rhino-laryngology and its related specialties 2017;79(3):153-163

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P2Y1, P2Y2, and TRPV1 Receptors Are Increased in Diarrhea-Predominant Irritable Bowel Syndrome and P2Y2 Correlates with Abdominal Pain.

Luo Y, Feng C, Wu J, Wu Y, Liu D, Wu J, Dai F, Zhang J
Digestive diseases and sciences 2016 Oct;61(10):2878-2886