12406-1-AP

antibody from Proteintech Group

Targeting: ACO1 IREB1, IREBP, IRP1

Provider product page for 12406-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [18]
Comments [0]
Validations
Western blot [1]

Submit

Product number: 12406-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12406-1-AP, RRID:AB_10642942
Product name: Aconitase 1 antibody
Antibody type: Polyclonal
Description: Aconitase 1 antibody (Cat. #12406-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ACO1 protein structure - 12406-1-AP shown in red.

Submitted references Iron overload reprogramming lipid metabolism through the IRP1-SCAP axis in fibroblast-like synoviocytes aggravates bone destruction in rheumatoid arthritis.

Liu Y, Fang L, Wang M, Zhong S, Xiong Y, Hou Y, Ren J, Li Y, Zhu W, Meng X, Lu C, Pan Y
Experimental & molecular medicine 2026 May 1;

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle.

Xie A, Brunner JS, Chakraborty S, Montero AM, Bridgeman AE, Paras KI, Cui R, Fagoaga-Eugui M, Komza M, Arnold PK, Jackson BT, Noriega Madrazo S, Atmane MI, Carrasco SE, Finley LWS
Cell 2026 Apr 30;189(9):2684-2699.e21

miR-210-3p Ameliorates Metabolic Dysfunction-Associated Steatohepatitis-Related Fibrosis by Targeting ISCU and Induces Ferroptosis.

Dai Z, Sun Z, Chen Q, Li Y, Sun Y, Jiao M, Yin X, Liu R, Liang H, Zhu C
Liver international : official journal of the International Association for the Study of the Liver 2025 Sep;45(9):e70282

Cancer Cell-Secreted miR-33a Reduces Stress Granule Formation by Targeting Polyamine Metabolism in Stroma to Promote Tumourigenesis.

Hu S, Li X, Hu Q, Wang C, Hua A, Deng G, Huang W, Fu X, Zhou H, Zhang X, Li M, Wu J, Chen M, Zhao X, Li L, Li Z, Wu M, Li J, Yan W
Journal of extracellular vesicles 2025 Sep;14(9):e70153

Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe(2+) through TRPML1 channel.

Xing Y, Wang MM, Zhang F, Xin T, Wang X, Chen R, Sui Z, Dong Y, Xu D, Qian X, Lu Q, Li Q, Cai W, Hu M, Wang Y, Cao JL, Cui D, Qi J, Wang W
Nature communications 2025 Jan 24;16(1):985

Liraglutide and GLP-1(9-37) alleviated hepatic ischemia-reperfusion injury by inhibiting ferroptosis via GSK3β/Nrf2 pathway and SMAD159/Hepcidin/FTH pathway.

Lu C, Xu C, Li S, Ni H, Yang J
Redox biology 2025 Feb;79:103468

L-ascorbate prevents non-alcoholic steatohepatitis-based hepatocarcinogenesis in Sod1/Prdx4 double-knockout mice.

Osaki T, Homma T, Maeda Y, Yamada KI, Yokoyama C, Toyokuni S, Fujii J
Scientific reports 2025 Dec 22;15(1):44312

Detection of Ferroptosis by Immunohistochemistry and Immunofluorescence.

Zhong X, Chen R
Methods in molecular biology (Clifton, N.J.) 2023;2712:211-222

NMDA receptor activation induces damage of alveolar type II cells and lung fibrogenesis through ferroptosis.

Cheng HP, Feng DD, Li XH, Gao LH, Qiu YJ, Liang XY, Zhou Y, Huang P, Shao M, Zhang YN, Chang YF, Fu JF, Huang YH, Liu W, Tang SY, Li C, Luo ZQ
Biochimica et biophysica acta. Molecular cell research 2023 Oct;1870(7):119535

SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux.

Mozzi A, Oldani M, Forcella ME, Vantaggiato C, Cappelletti G, Pontremoli C, Valenti F, Forni D, Saresella M, Biasin M, Sironi M, Fusi P, Cagliani R
iScience 2023 Jul 21;26(7):107118

KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element-binding protein 2.

Zhou H, Chen J, Fan M, Cai H, Dong Y, Qiu Y, Zhuang Q, Lei Z, Li M, Ding X, Yan P, Lin A, Zheng S, Yan Q
Journal of experimental & clinical cancer research : CR 2023 Jan 5;42(1):5

Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation.

Li MX, Wu XT, Jing WQ, Hou WK, Hu S, Yan W
Cell death & disease 2023 Aug 2;14(8):492

Asparagine starvation suppresses histone demethylation through iron depletion.

Jiang J, Srivastava S, Liu S, Seim G, Claude R, Zhong M, Cao S, Davé U, Kapur R, Mosley AL, Zhang C, Wan J, Fan J, Zhang J
iScience 2023 Apr 21;26(4):106425

Mitophagy, Ferritinophagy and Ferroptosis in Retinal Pigment Epithelial Cells Under High Glucose Conditions: Implications for Diabetic Retinopathy and Age-Related Retinal Diseases.

Singh LP, Yumnamcha T, Devi TS
JOJ ophthalmology 2021;8(5):77-85

Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.

Cheng H, Feng D, Li X, Gao L, Tang S, Liu W, Wu X, Yue S, Li C, Luo Z
Biochimica et biophysica acta. Molecular basis of disease 2021 Dec 1;1867(12):166204

Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite.

Ceccacci S, Deitersen J, Mozzicafreddo M, Morretta E, Proksch P, Wesselborg S, Stork B, Monti MC
Biomolecules 2020 Jun 2;10(6)

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington's disease.

Niu L, Ye C, Sun Y, Peng T, Yang S, Wang W, Li H
Cell & bioscience 2018;8:41

Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation.

Yang C, Ma X, Wang Z, Zeng X, Hu Z, Ye Z, Shen G
Drug design, development and therapy 2017;11:431-439

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Aconitase 1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Aconitase 1. This antibody recognizes human,mouse,rat antigen. The Aconitase 1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 12406-1-AP.pdf

: Show more