15910-1-AP

antibody from Proteintech Group

Targeting: ALDH1A1 ALDH1, PUMB1, RALDH1

Provider product page for 15910-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [122]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

Submit

Product number: 15910-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15910-1-AP, RRID:AB_2305276
Product name: ALDH1A1 antibody
Antibody type: Polyclonal
Description: ALDH1A1 antibody (Cat. #15910-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ALDH1A1 protein structure - 15910-1-AP shown in red.

Submitted references Melatonin inhibits the stemness of head and neck squamous cell carcinoma by modulating HA synthesis via the FOSL1/HAS3 axis.

Luo X, Wang J, Chen Y, Zhou X, Shao Z, Liu K, Shang Z
Journal of pineal research 2024 Mar;76(2):e12940

1-Benzylimidazole attenuates the stemness of breast cancer cells through partially targeting CYP4Z1.

Qin H, Zhou Y, Liu H, Yuan Y, Guo Q, Yuan M, Xi T, Zhang Y
Environmental toxicology 2024 Mar;39(3):1505-1520

Anti-pancreatic cancer activity of cassane diterpenoids isolated from the seeds of Caesalpinia sappan mediated by autophagy activation via ROS/AMPK/mTORC1 pathway.

Su J, Wang DS, Hu GX, Liu YY, Hu M, Chen Y, Wang QQ, Yan RC, Wu Y, Li YJ, Ma K, Qi YY, Ding LF, Wu XD
Phytochemistry 2024 Jun;222:114105

EphA2 promotes the transcription of KLF4 to facilitate stemness in oral squamous cell carcinoma.

Bai J, Chen Y, Sun Y, Wang X, Wang Y, Guo S, Shang Z, Shao Z
Cellular and molecular life sciences : CMLS 2024 Jun 25;81(1):278

Oridonin, a small molecule inhibitor of cancer stem cell with potent cytotoxicity and differentiation potential.

Li Y, Xie J, Du X, Chen Y, Wang C, Liu T, Yi Z, Wang Y, Zhao M, Li X, Shi S
European journal of pharmacology 2024 Jul 15;975:176656

Combining microfluidic chip and low-attachment culture devices to isolate oral cancer stem cells.

Chen HH, Nguyen TV, Shih YH, Chang KC, Chiu KC, Hsia SM, Fuh LJ, Shieh TM
Journal of dental sciences 2024 Jan;19(1):560-567

Lactate-driven type I collagen deposition facilitates cancer stem cell-like phenotype of head and neck squamous cell carcinoma.

Sun Y, Chen Y, Zhao H, Wang J, Liu Y, Bai J, Hu C, Shang Z
iScience 2024 Apr 19;27(4):109340

Butyrate attenuates the stemness of lung cancer cells through lysosome Fe(2+)- and SLC7A11-mediated ferroptosis.

Bi R, Jiang L, Hu R, Wen B, Jiang Z, Liu H, Mei J
Heliyon 2024 Apr 15;10(7):e28093

Sulforaphane Suppresses MCF-7 Breast Cancer Cells Growth via miR-19/PTEN Axis to Antagonize the Effect of Butyl Benzyl Phthalate.

Cao W, Lu X, Zhong C, Wu J
Nutrition and cancer 2023;75(3):980-991

Diallyl Trisulfide Suppresses the Renal Cancer Stem-like Cell Properties via Nanog.

Zhang T, Cao W, Sun H, Yu D, Zhong C
Nutrition and cancer 2023;75(3):971-979

Hepatitis B virus X protein induces ALDH2 ubiquitin-dependent degradation to enhance alcoholic steatohepatitis.

Zhou H, Wan S, Luo Y, Liu H, Jiang J, Guo Y, Xiao J, Wu B
Gastroenterology report 2023;11:goad006

SEC61 translocon subunit gamma enhances low-dose cisplatin-induced cancer-stem cell properties of head and neck squamous cell carcinoma via enhancing Ca(2+)-mediated autophagy.

Bu X, Zhang J, Sun H, Wang W, Ma X, Sun L
Journal of dental sciences 2023 Oct;18(4):1685-1692

Rab11-FIP4 interacts with ARF5 to promote cancer stemness in hepatocellular carcinoma.

Song F, Zhang Q, Lu X, Xu T, Hu Q, Hu X, Fan W, Zhang Y, Huang P
Journal of physiology and biochemistry 2023 Nov;79(4):757-770

Diallyl trisulfide inhibits gastric cancer stem cell properties through ΔNp63/sonic hedgehog pathway.

Ge M, Zhu J, Yi K, Chen Y, Cao W, Wang M, Xie C, Li X, Geng S, Wu J, Zhong C, Cao H, Jiang Z, Han H
Molecular carcinogenesis 2023 Nov;62(11):1673-1685

Modification of lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression.

Zhang Z, Wang Y, Liang Z, Meng Z, Zhang X, Ma G, Chen Y, Zhang M, Su Y, Li Z, Liang Y, Niu H
iScience 2023 Nov 17;26(11):108142

KK-LC-1 as a therapeutic target to eliminate ALDH(+) stem cells in triple negative breast cancer.

Bu J, Zhang Y, Wu S, Li H, Sun L, Liu Y, Zhu X, Qiao X, Ma Q, Liu C, Niu N, Xue J, Chen G, Yang Y, Liu C
Nature communications 2023 May 5;14(1):2602

Low-dose phthalates promote breast cancer stem cell properties via the oncogene ΔNp63α and the Sonic hedgehog pathway.

Cao WS, Zhao MJ, Chen Y, Zhu JY, Xie CF, Li XT, Geng SS, Zhong CY, Fu JY, Wu JS
Ecotoxicology and environmental safety 2023 Mar 1;252:114605

Frequent PIK3CA mutation in normal endometrial gland drives spheroid formation and may be involved in stem cell propagation.

Sato S, Nakayama K, Kanno K, Sultana R, Ishikawa M, Ishibashi T, Yamashita H, Kyo S
Cancer science 2023 Jun;114(6):2335-2344

LIMP-2 enhances cancer stem-like cell properties by promoting autophagy-induced GSK3β degradation in head and neck squamous cell carcinoma.

Liu Y, Li S, Wang S, Yang Q, Wu Z, Zhang M, Chen L, Sun Z
International journal of oral science 2023 Jun 8;15(1):24

HMGB3 promotes the malignant phenotypes and stemness of epithelial ovarian cancer through the MAPK/ERK signaling pathway.

Ma H, Qi G, Han F, Gai P, Peng J, Kong B
Cell communication and signaling : CCS 2023 Jun 16;21(1):144

Emodin reverses resistance to gemcitabine in pancreatic cancer by suppressing stemness through regulation of the epithelial‑mesenchymal transition.

Wei W, Wang J, Hu Y, Chen S, Liu J
Experimental and therapeutic medicine 2023 Jan;25(1):7

Resveratrol suppresses lung cancer by targeting cancer stem-like cells and regulating tumor microenvironment.

Xie C, Liang C, Wang R, Yi K, Zhou X, Li X, Chen Y, Miao D, Zhong C, Zhu J
The Journal of nutritional biochemistry 2023 Feb;112:109211

Eudesmane-type sesquiterpenoids from the aerial parts of Artemisia lavandulaefolia and their anti-pancreatic cancer activities.

Ding LF, Hu GX, Liu YY, Wang QH, Li ZJ, Shen MX, Zhu GF, Wu XD, Su J
Phytochemistry 2023 Dec;216:113871

Control by the brain of vitamin A homeostasis.

Imoesi PI, Olarte-Sánchez CM, Croce L, Blaner WS, Morgan PJ, Heisler L, McCaffery P
iScience 2023 Aug 18;26(8):107373

Palmitoyl transferases act as novel drug targets for pancreatic cancer.

Lin Z, Lv Z, Liu X, Huang K
Journal of translational medicine 2023 Apr 10;21(1):249

AKAP9 Upregulation Predicts Unfavorable Prognosis in Pediatric Acute Myeloid Leukemia and Promotes Stemness Properties via the Wnt/β-Catenin Pathway.

Wu S, Shen D, Zhao L
Cancer management and research 2022;14:157-167

Integrated Analysis of Transcriptome Data Revealed AURKA and KIF20A as Critical Genes in Medulloblastoma Progression.

Liang B, Zhou Y, Jiao J, Xu L, Yan Y, Wu Q, Tong X, Yan H
Frontiers in oncology 2022;12:875521

Biochemical Neuroadaptations in the Rat Striatal Dopaminergic System after Prolonged Exposure to Methamphetamine Self-Administration.

Jayanthi S, Ladenheim B, Sullivan P, McCoy MT, Krasnova IN, Goldstein DS, Cadet JL
International journal of molecular sciences 2022 Sep 3;23(17)

TAB182 aggravates progression of esophageal squamous cell carcinoma by enhancing β-catenin nuclear translocation through FHL2 dependent manner.

Gao A, Su Z, Shang Z, He C, Miao D, Li X, Zou S, Ding W, Zhou Y, Sun M, Zhou J
Cell death & disease 2022 Oct 26;13(10):900

MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling.

Zhou X, Luo J, Xie H, Wei Z, Li T, Liu J, Liao X, Zhu G, Peng T
Cell death discovery 2022 Oct 15;8(1):418

Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy.

Wu LMN, Zhang F, Rao R, Adam M, Pollard K, Szabo S, Liu X, Belcher KA, Luo Z, Ogurek S, Reilly C, Zhou X, Zhang L, Rubin J, Chang LS, Xin M, Yu J, Suva M, Pratilas CA, Potter S, Lu QR
Science advances 2022 Nov 4;8(44):eabo5442

Cancer-associated fibroblasts promote the stemness and progression of renal cell carcinoma via exosomal miR-181d-5p.

Ding M, Zhao X, Chen X, Diao W, Kan Y, Cao W, Chen W, Jiang B, Qin H, Gao J, Zhuang J, Zhang Q, Guo H
Cell death discovery 2022 Nov 1;8(1):439

Multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia.

Lin L, Song C, Wei Z, Zou H, Han S, Cao Z, Zhang X, Zhang G, Ran J, Cai Y, Han W
Journal of nanobiotechnology 2022 Mar 4;20(1):106

Claudin1 decrease induced by 1,25-dihydroxy-vitamin D3 potentiates gefitinib resistance therapy through inhibiting AKT activation-mediated cancer stem-like properties in NSCLC cells.

Jia Z, Wang K, Duan Y, Hu K, Zhang Y, Wang M, Xiao K, Liu S, Pan Z, Ding X
Cell death discovery 2022 Mar 18;8(1):122

Phenazine derivatives attenuate the stemness of breast cancer cells through triggering ferroptosis.

Yang Y, Lu Y, Zhang C, Guo Q, Zhang W, Wang T, Xia Z, Liu J, Cheng X, Xi T, Jiang F, Zheng L
Cellular and molecular life sciences : CMLS 2022 Jun 11;79(7):360

Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice.

Kasai A, Jee E, Tamura Y, Kouzaki K, Kotani T, Nakazato K
American journal of physiology. Regulatory, integrative and comparative physiology 2022 Jun 1;322(6):R511-R525

Effect of different types of muscle activity on the gene and protein expression of ALDH family members in C57BL/6J mouse skeletal muscle.

Jee E, Tamura Y, Kouzaki K, Kotani T, Nakazato K
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Jul 1;47(7):775-786

Autophagy regulates the cancer stem cell phenotype of head and neck squamous cell carcinoma through the noncanonical FOXO3/SOX2 axis.

Chen Y, Zhao H, Liang W, Jiang E, Zhou X, Shao Z, Liu K, Shang Z
Oncogene 2022 Jan;41(5):634-646

Tanshinone IIA attenuates the stemness of breast cancer cells via targeting the miR-125b/STARD13 axis.

Li X, Jia Q, Zhou Y, Jiang X, Song L, Wu Y, Wang A, Chen W, Wang S, Lu Y
Experimental hematology & oncology 2022 Jan 20;11(1):2

Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis.

Ni H, Ruan G, Sun C, Yang X, Miao Z, Li J, Chen Y, Qin H, Liu Y, Zheng L, Xing Y, Xi T, Li X
Environmental toxicology 2022 Feb;37(2):192-200

Capsaicin inhibits the stemness of anaplastic thyroid carcinoma cells by triggering autophagy-lysosome mediated OCT4A degradation.

Wu L, Xu S, Cheng X, Zhang L, Wang Y, Wu J, Bao J, Yu H, Lu R
Phytotherapy research : PTR 2022 Feb;36(2):938-950

FAT1 downregulation enhances stemness and cisplatin resistance in esophageal squamous cell carcinoma.

Zhai Y, Shan C, Zhang H, Kong P, Zhang L, Wang Y, Hu X, Cheng X
Molecular and cellular biochemistry 2022 Dec;477(12):2689-2702

Identification of a Novel Potent CYP4Z1 Inhibitor Attenuating the Stemness of Breast Cancer Cells through Lead Optimization.

Yuan Y, Yao H, Zhou M, Ma X, Zhou Y, Xu J, Niu M, Yin J, Zheng L, Xu S
Journal of medicinal chemistry 2022 Dec 8;65(23):15749-15769

The Ginsenoside Compound K Suppresses Stem-Cell-like Properties and Colorectal Cancer Metastasis by Targeting Hypoxia-Driven Nur77-Akt Feed-Forward Signaling.

Zhang M, Shi Z, Zhang S, Li X, To SKY, Peng Y, Liu J, Chen S, Hu H, Wong AST, Zeng JZ
Cancers 2022 Dec 20;15(1)

EBV promotes vascular mimicry of dormant cancer cells by potentiating stemness and EMT.

Cheng T, Zhang S, Xia T, Zhang Y, Ji Y, Pan S, Xie H, Ren Q, You Y, You B
Experimental cell research 2022 Dec 15;421(2):113403

Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop.

Shen Y, Zhu Q, Xiao M, Yin L, Feng W, Feng J, He J, Li P, Chen X, Ding W, Zhong J, Zeng Z, Xie Z, Liu J, Zu X
Cell death & disease 2022 Aug 30;13(8):749

MicroRNA-18 facilitates the stemness of gastric cancer by downregulating HMGB3 though targeting Meis2.

Zhang Y, Lin W, Jiang W, Wang Z
Bioengineered 2022 Apr;13(4):9959-9972

Histone methyltransferase KMT2D cooperates with MEF2A to promote the stem-like properties of oral squamous cell carcinoma.

Wang X, Li R, Wu L, Chen Y, Liu S, Zhao H, Wang Y, Wang L, Shao Z
Cell & bioscience 2022 Apr 27;12(1):49

Resveratrol Inhibition of Renal Cancer Stem Cell Characteristics and Modulation of the Sonic Hedgehog Pathway.

Sun H, Zhang T, Liu R, Cao W, Zhang Z, Liu Z, Qian W, Wang D, Yu D, Zhong C
Nutrition and cancer 2021;73(7):1157-1167

Pentraxin-3 inhibits milky spots metastasis of gastric cancer by inhibiting M2 macrophage polarization.

Cui X, Qin T, Zhao Z, Yang G, Sanches JGP, Zhang Q, Fan S, Cao L, Hu X
Journal of Cancer 2021;12(15):4686-4697

The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway.

Sanches JGP, Song B, Zhang Q, Cui X, Yabasin IB, Ntim M, Li X, He J, Zhang Y, Mao J, Lu Y, Li L
Frontiers in oncology 2021;11:637298

Proteome analysis identified proteins associated with mitochondrial function and inflammation activation crucially regulating the pathogenesis of fatty liver disease.

Zhang L, Liu T, Hu C, Zhang X, Zhang Q, Shi K
BMC genomics 2021 Sep 4;22(1):640

RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis.

Tognoli ML, Vlahov N, Steenbeek S, Grawenda AM, Eyres M, Cano-Rodriguez D, Scrace S, Kartsonaki C, von Kriegsheim A, Willms E, Wood MJ, Rots MG, van Rheenen J, O'Neill E, Pankova D
The EMBO journal 2021 Oct 18;40(20):e107680

Abnormally elevated ubiquilin‑1 expression in breast cancer regulates metastasis and stemness via AKT signaling.

Feng X, Cao A, Qin T, Zhang Q, Fan S, Wang B, Song B, Yu X, Li L
Oncology reports 2021 Nov;46(5)

Apatinib suppresses lung cancer stem-like cells by complex interplay between β-catenin signaling and mitochondrial ROS accumulation.

Zhu J, Li X, Liang C, Zhou X, Ge M, Chen Y, Jin J, Yin J, Xu H, Xie C, Zhong C
Cell death discovery 2021 May 12;7(1):102

Diallyl trisulfide inhibited tobacco smoke-mediated bladder EMT and cancer stem cell marker expression via the NF-κB pathway in vivo.

Geng H, Guo W, Feng L, Xie D, Bi L, Wang Y, Zhang T, Liang Z, Yu D
The Journal of international medical research 2021 Mar;49(3):300060521992900

HET0016 attenuates the stemness of breast cancer cells through targeting CYP4Z1.

Liu H, Qin H, Zhou Y, Yuan Y, Liu Y, Chen Y, Yang Y, Ni H, Xi T, Zheng L
Molecular carcinogenesis 2021 Jun;60(6):413-426

Diallyl trisulphide, a H(2) S donor, compromises the stem cell phenotype and restores thyroid-specific gene expression in anaplastic thyroid carcinoma cells by targeting AKT-SOX2 axis.

Zhang L, Xu S, Cheng X, Zheng J, Wang Y, Wu J, Wang X, Wu L, Yu H, Bao J
Phytotherapy research : PTR 2021 Jun;35(6):3428-3443

MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis.

Ni H, Qin H, Sun C, Liu Y, Ruan G, Guo Q, Xi T, Xing Y, Zheng L
Stem cell research & therapy 2021 Jun 5;12(1):325

Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid.

Yu Q, Biswas S, Ma G, Zhao P, Li B, Li J
eLife 2021 Jun 4;10

Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons.

Flor A, Wolfgeher D, Li J, Hanakahi LA, Kron SJ
Cell chemical biology 2021 Jun 17;28(6):776-787.e8

Tadalafil Reverses the Effect of Three-Dimensional Cell Culture System on Stem Cell Features in A549 and SK-MES-1.

Li M, Liu Y, Zhang W, Li C, Zhu Y, Wang S
DNA and cell biology 2021 Jul;40(7):869-880

HOXB7 acts as an oncogenic biomarker in head and neck squamous cell carcinoma.

Wu X, Li J, Yan T, Ke X, Li X, Zhu Y, Yang J, Li Z
Cancer cell international 2021 Jul 24;21(1):393

A "dual-guide" bioinspired drug delivery strategy of a macrophage-based carrier against postoperative triple-negative breast cancer recurrence.

Qiu Y, Ren K, Zhao W, Yu Q, Guo R, He J, Mei L, Liu Y, Tang J, Xu S, Li J, Wei J, Li M, Zhang Z, He Q
Journal of controlled release : official journal of the Controlled Release Society 2021 Jan 10;329:191-204

Benzidine promotes the stemness of bladder cancer stem cells via activation of the Sonic hedgehog pathway.

Wang D, Xie D, Bi L, Wang Y, Zou C, Chen L, Geng H, Qian W, Li Y, Sun H, Wang X, Lu Y, Yu D, Zhong C
Oncology letters 2021 Feb;21(2):146

Lysosome Fe(2+) release is responsible for etoposide- and cisplatin-induced stemness of small cell lung cancer cells.

Wang K, Chen X, Zuyi W, Chen L, Fu W
Environmental toxicology 2021 Aug;36(8):1654-1663

FOXD1 promotes EMT and cell stemness of oral squamous cell carcinoma by transcriptional activation of SNAI2.

Chen Y, Liang W, Liu K, Shang Z
Cell & bioscience 2021 Aug 4;11(1):154

Ginger Increases ALDH1A1 Expression and Enhances Retinoic Acid Signaling in a Human Colonic Epithelial Cell Line.

Nagata Y, Yamamoto T, Kadowaki M
Journal of nutritional science and vitaminology 2020;66(5):462-467

Cigarette smoke supports stemness and epithelial-mesenchymal transition in bladder cancer stem cells through SHH signaling.

Sun X, Song J, Li E, Geng H, Li Y, Yu D, Zhong C
International journal of clinical and experimental pathology 2020;13(6):1333-1348

CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway.

Chen Y, Shao Z, Jiang E, Zhou X, Wang L, Wang H, Luo X, Chen Q, Liu K, Shang Z
Journal of cellular physiology 2020 Sep;235(9):5995-6009

Expression level of PD-L1 is involved in ALDH1A1-mediated poor prognosis in patients with head and neck squamous cell carcinoma.

Zhou AL, Wang X, Yu W, Yang L, Wei F, Sun Q, Wang Y, Kou F, Dong R, Ren X, Zhang X
Pathology, research and practice 2020 Sep;216(9):153093

Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity.

Guo Q, Wang T, Yang Y, Gao L, Zhao Q, Zhang W, Xi T, Zheng L
Molecular therapy. Nucleic acids 2020 Sep 4;21:527-541

Nanog mediates tobacco smoke-induced enhancement of renal cancer stem cell properties.

Zhang T, Sun H, Liu R, Cao W, Zhang T, Li E, Sun X, Wu W, Yu D, Zhong C
Environmental toxicology 2020 Nov;35(11):1274-1283

Acylglycerol kinase promotes the stemness of nasopharyngeal carcinoma cells by promoting β-catenin translocation to the nucleus through activating PI3K/Akt pathway.

Zhao Q, Sun P, Qin S, Liu J
Environmental toxicology 2020 Dec;35(12):1299-1307

Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.

Wakabayashi Y, Tamura Y, Kouzaki K, Kikuchi N, Hiranuma K, Menuki K, Tajima T, Yamanaka Y, Sakai A, Nakayama KI, Kawamoto T, Kitagawa K, Nakazato K
American journal of physiology. Regulatory, integrative and comparative physiology 2020 Apr 1;318(4):R677-R690

Sulforaphane Inhibits the Acquisition of Tobacco Smoke-Induced Lung Cancer Stem Cell-Like Properties via the IL-6/ΔNp63α/Notch Axis.

Xie C, Zhu J, Jiang Y, Chen J, Wang X, Geng S, Wu J, Zhong C, Li X, Meng Z
Theranostics 2019;9(16):4827-4840

Sonic hedgehog pathway mediates genistein inhibition of renal cancer stem cells.

Li E, Zhang T, Sun X, Li Y, Geng H, Yu D, Zhong C
Oncology letters 2019 Sep;18(3):3081-3091

Genistein inhibits nasopharyngeal cancer stem cells through sonic hedgehog signaling.

Zhang Q, Cao WS, Wang XQ, Zhang M, Lu XM, Chen JQ, Chen Y, Ge MM, Zhong CY, Han HY
Phytotherapy research : PTR 2019 Oct;33(10):2783-2791

Limonin enhances the radiosensitivity of nasopharyngeal carcinoma cells via attenuating Stat3-induced cell stemness.

Gao L, Sang JZ, Cao H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109366

Disulfiram suppressed ethanol promoted RANKL-induced osteoclastogenesis in vitro and ethanol-induced osteoporosis in vivo via ALDH1A1-NFATc1 axis.

Jia Y, Jiang J, Zhao K, Zhang T, Sun P, Peng J, Yang Q, Qian Y
Aging 2019 Oct 8;11(19):8103-8119

Targeting Frizzled-7 Decreases Stemness and Chemotherapeutic Resistance in Gastric Cancer Cells by Suppressing Myc Expression.

Cheng Y, Li L, Pan S, Jiang H, Jin H
Medical science monitor : international medical journal of experimental and clinical research 2019 Nov 16;25:8637-8644

WITHDRAWN: Tanshinone IIA-mediated inhibition on miR-125b/STARD13 axis attenuates the stemness and enhances adriamycin sensitivity of breast cancer cells.

Li X, Zheng L, Xi T
Biochimie 2019 May 9;

SLC34A2 promotes neuroblastoma cell stemness via enhancement of miR-25/Gsk3β-mediated activation of Wnt/β-catenin signaling.

Chen J, Wang P, Cai R, Peng H, Zhang C, Zhang M
FEBS open bio 2019 Mar;9(3):527-537

PTEN downregulates WD repeat‑containing protein 66 in salivary adenoid cystic carcinoma.

Cao Y, Liu H, Xia SL, Zhang X, Bai H, Yang Q, Li J, Gao L, Jin F, Wei MJ, Lu SL, Xiao J
Oncology reports 2019 Mar;41(3):1827-1836

Knockdown of USF1 Inhibits the Vasculogenic Mimicry of Glioma Cells via Stimulating SNHG16/miR-212-3p and linc00667/miR-429 Axis.

Wang D, Zheng J, Liu X, Xue Y, Liu L, Ma J, He Q, Li Z, Cai H, Liu Y
Molecular therapy. Nucleic acids 2019 Mar 1;14:465-482

CSC-3436 inhibits TWIST-induced epithelial-mesenchymal transition via the suppression of Twist/Bmi1/Akt pathway in head and neck squamous cell carcinoma.

Lai YJ, Yu WN, Kuo SC, Ho CT, Hung CM, Way TD, Chen CT
Journal of cellular physiology 2019 Jun;234(6):9118-9129

RNA binding protein PUM2 promotes the stemness of breast cancer cells via competitively binding to neuropilin-1 (NRP-1) mRNA with miR-376a.

Zhang L, Chen Y, Li C, Liu J, Ren H, Li L, Zheng X, Wang H, Han Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jun;114:108772

TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.

Zhu R, Gires O, Zhu L, Liu J, Li J, Yang H, Ju G, Huang J, Ge W, Chen Y, Lu Z, Wang H
Nature communications 2019 Jun 28;10(1):2863

Matrix stiffness mediates stemness characteristics via activating the Yes-associated protein in colorectal cancer cells.

Tan F, Huang Y, Pei Q, Liu H, Pei H, Zhu H
Journal of cellular biochemistry 2019 Feb;120(2):2213-2225

Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway.

Ge M, Zhang L, Cao L, Xie C, Li X, Li Y, Meng Y, Chen Y, Wang X, Chen J, Zhang Q, Shao J, Zhong C
International journal of food sciences and nutrition 2019 Aug;70(5):570-578

LncRNA THOR increases osteosarcoma cell stemness and migration by enhancing SOX9 mRNA stability.

Wu H, He Y, Chen H, Liu Y, Wei B, Chen G, Lin H, Lin H
FEBS open bio 2019 Apr;9(4):781-790

Depletion of the lncRNA RP11-567G11.1 inhibits pancreatic cancer progression.

Huang R, Nie W, Yao K, Chou J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108685

Breast fibroblasts in both cancer and normal tissues induce phenotypic transformation of breast cancer stem cells: a preliminary study.

Wang B, Xi C, Liu M, Sun H, Liu S, Song L, Kang H
PeerJ 2018;6:e4805

LncRNA UCA1 is necessary for TGF-β-induced epithelial-mesenchymal transition and stemness via acting as a ceRNA for Slug in glioma cells.

Li Z, Liu H, Zhong Q, Wu J, Tang Z
FEBS open bio 2018 Nov;8(11):1855-1865

Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity.

Qin T, Li B, Feng X, Fan S, Liu L, Liu D, Mao J, Lu Y, Yang J, Yu X, Zhang Q, Zhang J, Song B, Li M, Li L
Journal of experimental & clinical cancer research : CR 2018 Nov 27;37(1):287

Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway.

Li X, Meng Y, Xie C, Zhu J, Wang X, Li Y, Geng S, Wu J, Zhong C, Li M
Journal of cellular biochemistry 2018 May;119(5):4134-4141

Wnt/β-catenin signaling mediates the suppressive effects of diallyl trisulfide on colorectal cancer stem cells.

Zhang Q, Li XT, Chen Y, Chen JQ, Zhu JY, Meng Y, Wang XQ, Li Y, Geng SS, Xie CF, Wu JS, Zhong CY, Han HY
Cancer chemotherapy and pharmacology 2018 Jun;81(6):969-977

Wnt/β-catenin modulates chronic tobacco smoke exposure-induced acquisition of pulmonary cancer stem cell properties and diallyl trisulfide intervention.

Wang J, Chen J, Jiang Y, Shi Y, Zhu J, Xie C, Geng S, Wu J, Zhang Q, Wang X, Meng Y, Li Y, Chen Y, Cao W, Wang X, Zhong C, Li X
Toxicology letters 2018 Jul;291:70-76

Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders.

Xu X, Li C, Gao X, Xia K, Guo H, Li Y, Hao Z, Zhang L, Gao D, Xu C, Xu H, Xiong ZQ, Qiu Z, Mei L, Xie X, Ruan K, Hu R
Cell research 2018 Jan;28(1):48-68

Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway.

Chen Y, Li Y, Wang XQ, Meng Y, Zhang Q, Zhu JY, Chen JQ, Cao WS, Wang XQ, Xie CF, Li XT, Geng SS, Wu JS, Zhong CY, Han HY
Phytotherapy research : PTR 2018 Dec;32(12):2447-2455

Salinomycin suppresses cancer cell stemness and attenuates TGF-β-induced epithelial-mesenchymal transition of renal cell carcinoma cells.

Liu L, Wang Q, Mao J, Qin T, Sun Y, Yang J, Han Y, Li L, Li Q
Chemico-biological interactions 2018 Dec 25;296:145-153

Six2 is negatively correlated with good prognosis and decreases 5-FU sensitivity via suppressing E-cadherin expression in hepatocellular carcinoma cells.

Li JW, Huang CZ, Li JH, Yuan JH, Chen QH, Zhang WF, Xu ZS, Liu YP, Li Y, Zhan MX, Lu LG
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:204-210

miR34a/GOLPH3 Axis abrogates Urothelial Bladder Cancer Chemoresistance via Reduced Cancer Stemness.

Zhang Q, Zhuang J, Deng Y, Yang L, Cao W, Chen W, Lin T, Lv X, Yu H, Xue Y, Guo H
Theranostics 2017;7(19):4777-4790

Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.

Wang D, Kong X, Li Y, Qian W, Ma J, Wang D, Yu D, Zhong C
Biochemical and biophysical research communications 2017 Nov 4;493(1):521-527

Protein tyrosine phosphatase receptor-type δ acts as a negative regulator suppressing breast cancer.

Yu X, Zhang F, Mao J, Lu Y, Li J, Ma W, Fan S, Zhang C, Li Q, Wang B, Song B, Li L
Oncotarget 2017 Nov 17;8(58):98798-98811

miR-221/222 promote cancer stem-like cell properties and tumor growth of breast cancer via targeting PTEN and sustained Akt/NF-κB/COX-2 activation.

Li B, Lu Y, Yu L, Han X, Wang H, Mao J, Shen J, Wang B, Tang J, Li C, Song B
Chemico-biological interactions 2017 Nov 1;277:33-42

miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells.

Zhu J, Wang S, Chen Y, Li X, Jiang Y, Yang X, Li Y, Wang X, Meng Y, Zhu M, Ma X, Huang C, Wu R, Xie C, Geng S, Wu J, Zhong C, Han H
The Journal of nutritional biochemistry 2017 Jun;44:80-91

Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells.

Zhu J, Jiang Y, Yang X, Wang S, Xie C, Li X, Li Y, Chen Y, Wang X, Meng Y, Zhu M, Wu R, Huang C, Ma X, Geng S, Wu J, Zhong C
Biochemical and biophysical research communications 2017 Jan 1;482(1):15-21

Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways.

Zhu JY, Yang X, Chen Y, Jiang Y, Wang SJ, Li Y, Wang XQ, Meng Y, Zhu MM, Ma X, Huang C, Wu R, Xie CF, Li XT, Geng SS, Wu JS, Zhong CY, Han HY
Phytotherapy research : PTR 2017 Apr;31(4):680-688

Depletion of Dicer promotes epithelial ovarian cancer progression by elevating PDIA3 expression.

Zhu Y, Cai L, Guo J, Chen N, Yi X, Zhao Y, Cai J, Wang Z
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):14009-14023

Restoring Retinoic Acid Attenuates Intestinal Inflammation and Tumorigenesis in APCMin/+ Mice.

Penny HL, Prestwood TR, Bhattacharya N, Sun F, Kenkel JA, Davidson MG, Shen L, Zuniga LA, Seeley ES, Pai R, Choi O, Tolentino L, Wang J, Napoli JL, Engleman EG
Cancer immunology research 2016 Nov;4(11):917-926

De Novo-Synthesized Retinoic Acid in Ovarian Antral Follicles Enhances FSH-Mediated Ovarian Follicular Cell Differentiation and Female Fertility.

Kawai T, Yanaka N, Richards JS, Shimada M
Endocrinology 2016 May;157(5):2160-72

The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.

Zheng ZG, Xu H, Suo SS, Xu XL, Ni MW, Gu LH, Chen W, Wang LY, Zhao Y, Tian B, Hua YJ
Scientific reports 2016 May 19;6:26093

Aldehyde dehydrogenase 1A1 up-regulates stem cell markers in benzo[a]pyrene-induced malignant transformation of BEAS-2B cells.

Liu Y, Lu R, Gu J, Chen Y, Zhang X, Zhang L, Wu H, Hua W, Zeng J
Environmental toxicology and pharmacology 2016 Jul;45:241-50

NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell.

Zhao ZL, Zhang L, Huang CF, Ma SR, Bu LL, Liu JF, Yu GT, Liu B, Gutkind JS, Kulkarni AB, Zhang WF, Sun ZJ
Scientific reports 2016 Apr 25;6:24704

Ex Vivo Propagation of Human Corneal Stromal "Activated Keratocytes" for Tissue Engineering.

Yam GH, Yusoff NZ, Kadaba A, Tian D, Myint HH, Beuerman RW, Zhou L, Mehta JS
Cell transplantation 2015;24(9):1845-61

Anterior gradient protein 2 expression in high grade head and neck squamous cell carcinoma correlated with cancer stem cell and epithelial mesenchymal transition.

Ma SR, Wang WM, Huang CF, Zhang WF, Sun ZJ
Oncotarget 2015 Apr 20;6(11):8807-21

CD163+ tumor-associated macrophages correlated with poor prognosis and cancer stem cells in oral squamous cell carcinoma.

He KF, Zhang L, Huang CF, Ma SR, Wang YF, Wang WM, Zhao ZL, Liu B, Zhao YF, Zhang WF, Sun ZJ
BioMed research international 2014;2014:838632

Maternal aldehyde elimination during pregnancy preserves the fetal genome.

Oberbeck N, Langevin F, King G, de Wind N, Crossan GP, Patel KJ
Molecular cell 2014 Sep 18;55(6):807-817

Correlation of ALDH1, CD44, OCT4 and SOX2 in tongue squamous cell carcinoma and their association with disease progression and prognosis.

Huang CF, Xu XR, Wu TF, Sun ZJ, Zhang WF
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2014 Aug;43(7):492-8

Properties of lewis lung carcinoma cells surviving curcumin toxicity.

Yan D, Geusz ME, Jamasbi RJ
Journal of Cancer 2012;3:32-41

Effects of curcumin on stem-like cells in human esophageal squamous carcinoma cell lines.

Almanaa TN, Geusz ME, Jamasbi RJ
BMC complementary and alternative medicine 2012 Oct 24;12:195

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse liver tissue were subjected to SDS PAGE followed by western blot with 15910-1-AP(ALDH1A1 antibody) at dilution of 1:400
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human eye using 15910-1-AP(ALDH1A1 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ALDH1A1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ALDH1A1. This antibody recognizes human,mouse,rat antigen. The ALDH1A1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 15910-1-AP.pdf

: Show more