Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60463 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- LIF polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human LIF.
- Description
- Embryonic stem (ES) cells are the focus of much research and represent great therapeutic potential as they can be propagated indefinitely in an undifferentiated state while possessing the ability to differentiate into all embryonic germ layers (endoderm, ectoderm and mesoderm) both in vivo and in vitro. LIF (leukemia inhibitory factor), also known as MLPLI (melanoma-derived LPL inhibitor), HILDA, DIA or CDF, is a 202 amino acid secreted protein and lymphoid factor that participates in the maintenance of ES cell pluripotency by suppressing spontaneous ES cell differentiation. Secreted LIF precursor is further processed into a biologically active glycoprotein. Expressed by a wide variety of cells including activated T lymphocytes, monocytes, mast cells and neuronal cells, LIF is suggested to promote survival and growth of axons in vitro and is involved in immune tolerance at the maternal-fetal interface. LIF may also participate in fat and bone metabolism and regulate epithelial conversion during kidney development.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of LIF pAb at 1:500 dilutionLane1:Jurkat whole cell lysateLane2:NIH-3T3 whole cell lysateLane3:PC12 whole cell lysate