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- References [25]
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- Product number
- 14609-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- SMPD1,ASM antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SMPD1,ASM antibody (Cat. #14609-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation.
Ceramide-rich extracellular vesicles as pathogenic biomarkers in traumatic brain injury.
Dapagliflozin induces renal lipidomic remodeling and systemic metabolic improvement.
Nicotine Reprograms Aging-Related Metabolism and Protects Against Motor Decline in Mice.
Inhibition of acid sphingomyelinase increases SMN levels and connects sphingolipid metabolism to Spinal Muscular Atrophy.
Ceramide mediates cell-to-cell ER stress transmission by modulating membrane fluidity.
Acid sphingomyelinase recruits palmitoylated CD36 to membrane rafts and enhances lipid uptake.
Integratomic investigation to assess the liver lipidomic and antiinflammatory activity of lupin protein hydrolysate.
Ceramide-mediated orchestration of oxidative stress response through filopodia-derived small extracellular vesicles.
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.
Targeting lysosomal HSP70 induces acid sphingomyelinase-mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies.
Novel Isolation Method Reveals Sex-Specific Composition and Neurotoxicity of Small Extracellular Vesicles in a Mouse Model of Alzheimer's Disease.
Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma.
Polyphyllin D punctures hypertrophic lysosomes to reverse drug resistance of hepatocellular carcinoma by targeting acid sphingomyelinase.
Proteome-Wide Analysis Reveals TFEB Targets for Establishment of a Prognostic Signature to Predict Clinical Outcomes of Colorectal Cancer.
Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer's disease pathology in the 5xFAD mouse.
Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer's Disease.
Exercise Promotes Pro-Apoptotic Ceramide Signaling in a Mouse Melanoma Model.
Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein.
Lycium barbarum polysaccharides attenuates high glucose-induced diabetic retinal angiogenesis by rescuing the expression of miR-15a-5p in RF/6A cells.
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Comparative lipidomics of 5-Fluorouracil-sensitive and -resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1).
Interrelations of Sphingolipid and Lysophosphatidate Signaling with Immune System in Ovarian Cancer.
The β(2) Integrin Mac-1 Induces Protective LC3-Associated Phagocytosis of Listeria monocytogenes.
Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.
Jia J, Gan Y, Li J, Li L, Meng H, Sun M, Ye L, Mao R, Cao X, Xia S, Bao X, Liu R, Zhang M, Xu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e17825
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e17825
Ceramide-rich extracellular vesicles as pathogenic biomarkers in traumatic brain injury.
Quadri Z, Zhu Z, Ren X, Crivelli SM, Zhang L, Kunjadia PD, Sullivan PG, Broome BB, Yamasaki TR, Bieberich E
bioRxiv : the preprint server for biology 2026 Apr 3;
bioRxiv : the preprint server for biology 2026 Apr 3;
Dapagliflozin induces renal lipidomic remodeling and systemic metabolic improvement.
Li A, Ye Y, Tang J, Hu J, Shi M, Wu Y, Ji C, Zhang H
Biology direct 2026 Apr 17;21(1)
Biology direct 2026 Apr 17;21(1)
Nicotine Reprograms Aging-Related Metabolism and Protects Against Motor Decline in Mice.
Jia S, Jing X, Wang R, Su M, Wang P, Feng Y, Ren X, Tu L, Wei P, Lu Z, Jia Y, Hong F, Mo Z, Zou J, Huang K, Yan C, Zou Q, Wang L, Zhong G, Zeng Z, Yu Q, Su W, Yang X, Pan F, Wang J, Wang L, Kang L, Kenny PJ, Chen Z, Liu XA
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e15311
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e15311
Inhibition of acid sphingomyelinase increases SMN levels and connects sphingolipid metabolism to Spinal Muscular Atrophy.
Brokate-Llanos AM, Beltran M, Garzón A, Garcera A, Miralles MP, Celma-Nos F, Campoy-López A, Soler RM, Muñoz MJ, Pérez-Pulido AJ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Nov;192:118610
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Nov;192:118610
Ceramide mediates cell-to-cell ER stress transmission by modulating membrane fluidity.
Huo Y, Liu X, Lu C, Li T, Yang Z, Xu F, Chen S, Yin K, Wang L
The Journal of cell biology 2025 May 5;224(5)
The Journal of cell biology 2025 May 5;224(5)
Acid sphingomyelinase recruits palmitoylated CD36 to membrane rafts and enhances lipid uptake.
Ding M, Zhang Y, Xu X, Zhu Y, He H, Jiang T, Huang Y, Yu W, Ou H
The Journal of biological chemistry 2025 Jun;301(6):110213
The Journal of biological chemistry 2025 Jun;301(6):110213
Integratomic investigation to assess the liver lipidomic and antiinflammatory activity of lupin protein hydrolysate.
Casati S, Dei Cas M, d'Adduzio L, Cruz-Chamorro I, Santos-Sánchez G, Bollati C, Fanzaga M, Pedroche J, Millán-Linares MDC, Roda G, Carrillo-Vico A, Lammi C
NPJ science of food 2025 Jul 28;9(1):154
NPJ science of food 2025 Jul 28;9(1):154
Ceramide-mediated orchestration of oxidative stress response through filopodia-derived small extracellular vesicles.
Quadri Z, Elsherbini A, Crivelli SM, El-Amouri SS, Tripathi P, Zhu Z, Ren X, Zhang L, Spassieva SD, Nikolova-Karakashian M, Bieberich E
Journal of extracellular vesicles 2024 Jul;13(7):e12477
Journal of extracellular vesicles 2024 Jul;13(7):e12477
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.
He Y, Kaya I, Shariatgorji R, Lundkvist J, Wahlberg LU, Nilsson A, Mamula D, Kehr J, Zareba-Paslawska J, Biverstål H, Chergui K, Zhang X, Andren PE, Svenningsson P
Nature communications 2023 Sep 19;14(1):5804
Nature communications 2023 Sep 19;14(1):5804
Targeting lysosomal HSP70 induces acid sphingomyelinase-mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies.
Qing Y, Guo Y, Zhao Q, Hu P, Li H, Yu X, Zhu M, Wang H, Wang Z, Xu J, Guo Q, Hui H
Clinical and translational medicine 2023 Mar;13(3):e1229
Clinical and translational medicine 2023 Mar;13(3):e1229
Novel Isolation Method Reveals Sex-Specific Composition and Neurotoxicity of Small Extracellular Vesicles in a Mouse Model of Alzheimer's Disease.
Elsherbini A, Zhu Z, Quadri Z, Crivelli SM, Ren X, Vekaria HJ, Tripathi P, Zhang L, Zhi W, Bieberich E
Cells 2023 Jun 14;12(12)
Cells 2023 Jun 14;12(12)
Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma.
Wilson GC, Patel SH, Wang J, Xu K, Turner KM, Becker KA, Carpinteiro A, Szabo I, Ahmad SA, Gulbins E
Journal of molecular medicine (Berlin, Germany) 2023 Jul;101(7):891-903
Journal of molecular medicine (Berlin, Germany) 2023 Jul;101(7):891-903
Polyphyllin D punctures hypertrophic lysosomes to reverse drug resistance of hepatocellular carcinoma by targeting acid sphingomyelinase.
Wang Y, Chen YY, Gao GB, Zheng YH, Yu NN, Ouyang L, Gao X, Li N, Wen SY, Huang S, Zhao Q, Liu L, Cao M, Zhang S, Zhang J, He QY
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Jul 5;31(7):2169-2187
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Jul 5;31(7):2169-2187
Proteome-Wide Analysis Reveals TFEB Targets for Establishment of a Prognostic Signature to Predict Clinical Outcomes of Colorectal Cancer.
Huang Z, Zhu S, Han Z, Li C, Liang J, Wang Y, Zhang S, Zhang J
Cancers 2023 Jan 25;15(3)
Cancers 2023 Jan 25;15(3)
Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer's disease pathology in the 5xFAD mouse.
Crivelli SM, Quadri Z, Vekaria HJ, Zhu Z, Tripathi P, Elsherbini A, Zhang L, Sullivan PG, Bieberich E
Acta neuropathologica communications 2023 Aug 21;11(1):135
Acta neuropathologica communications 2023 Aug 21;11(1):135
Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer's Disease.
Qi YY, Heng X, Yao ZY, Qu SY, Ge PY, Zhao X, Ni SJ, Guo R, Yang NY, Zhang QC, Zhu HX
Drug design, development and therapy 2022;16:931-950
Drug design, development and therapy 2022;16:931-950
Exercise Promotes Pro-Apoptotic Ceramide Signaling in a Mouse Melanoma Model.
Lee J, Savage H, Maegawa S, Ballarò R, Pareek S, Guerrouahen BS, Gopalakrishnan V, Schadler K
Cancers 2022 Sep 2;14(17)
Cancers 2022 Sep 2;14(17)
Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein.
Liu XT, Chung LH, Liu D, Chen J, Huang Y, Teo JD, Han XD, Zhao Y, Guan FHX, Tran C, Lee JY, Couttas TA, Liu K, McCaughan GW, Gorrell MD, Don AS, Zhang S, Qi Y
Oncogenesis 2022 Nov 4;11(1):67
Oncogenesis 2022 Nov 4;11(1):67
Lycium barbarum polysaccharides attenuates high glucose-induced diabetic retinal angiogenesis by rescuing the expression of miR-15a-5p in RF/6A cells.
Zhu Y, Zhao Q, Jiang Y
Journal of ethnopharmacology 2022 Jan 30;283:114652
Journal of ethnopharmacology 2022 Jan 30;283:114652
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Cai BB, Lu YN, Xu M
Acta pharmacologica Sinica 2020 May;41(5):650-660
Acta pharmacologica Sinica 2020 May;41(5):650-660
Comparative lipidomics of 5-Fluorouracil-sensitive and -resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1).
Jung JH, Taniguchi K, Lee HM, Lee MY, Bandu R, Komura K, Lee KY, Akao Y, Kim KP
Scientific reports 2020 Apr 9;10(1):6124
Scientific reports 2020 Apr 9;10(1):6124
Interrelations of Sphingolipid and Lysophosphatidate Signaling with Immune System in Ovarian Cancer.
Meshcheryakova A, Svoboda M, Jaritz M, Mungenast F, Salzmann M, Pils D, Cacsire Castillo-Tong D, Hager G, Wolf A, Braicu EI, Sehouli J, Lambrechts S, Vergote I, Mahner S, Birner P, Zimmermann P, Brindley DN, Heinze G, Zeillinger R, Mechtcheriakova D
Computational and structural biotechnology journal 2019;17:537-560
Computational and structural biotechnology journal 2019;17:537-560
The β(2) Integrin Mac-1 Induces Protective LC3-Associated Phagocytosis of Listeria monocytogenes.
Gluschko A, Herb M, Wiegmann K, Krut O, Neiss WF, Utermöhlen O, Krönke M, Schramm M
Cell host & microbe 2018 Mar 14;23(3):324-337.e5
Cell host & microbe 2018 Mar 14;23(3):324-337.e5
Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.
Tang YC, Yuwen H, Wang K, Bruno PM, Bullock K, Deik A, Santaguida S, Trakala M, Pfau SJ, Zhong N, Huang T, Wang L, Clish CB, Hemann MT, Amon A
Cancer research 2017 Oct 1;77(19):5272-5286
Cancer research 2017 Oct 1;77(19):5272-5286
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SMPD1,ASM antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SMPD1,ASM. This antibody recognizes human,mouse,rat antigen. The SMPD1,ASM antibody has been validated for the following applications: ELISA, WB analysis.
