Antibody data

Product number
BS60373 - Provider product page
Provider
Bioworld Technology, Inc
Product name
ASM polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human ASM.
Description
Acid sphingomyelinase (ASM) is a lysosomal protein that hydrolyzes sphingomyelin to ceramide and phosphocholine. The ASM gene encodes three proteins, ASM-1, ASM-2 and ASM-3, of which ASM-1 is the only ASM gene product that is a catalytically active enzyme. Deficiency of ASM is associated with type A and type B Niemann-Pick disease. Type A is a fatal neurodegenerative disorder seen in infancy and resulting in death by age three, whereas type B is a non-neuropathic disease that has a later onset. During monocytic cell differentiation, the expression of ASM is upregulated by the combined actions of AP-2 and Sp1 transcription factors.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SMPD1 protein structure - BS60373 shown in red.