MAB295

antibody from R&D Systems

Targeting: OSM MGC20461

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Blocking/Neutralizing (Recommended by provider)

Antibody Data

Product number

MAB295

Provider

R&D Systems

Product name

Anti-Human Oncostatin M/OSM Monoclonal Antibody (Clone 17001)

Antibody type

Monoclonal

Antigen

E. coli-derived recombinant human Oncostatin M/OSM, Ala26-Arg234

Description

Protein A or G purified from ascites

Reactivity

Human

Host

Mouse

Antigen sequence

P13725


Isotype

IgG

Vial size

500 µg

References

Submitted references

The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by α-PD-L1 or α-IL6 antibodies.

Rolvering C, Zimmer AD, Ginolhac A, Margue C, Kirchmeyer M, Servais F, Hermanns HM, Hergovits S, Nazarov PV, Nicot N, Kreis S, Haan S, Behrmann I, Haan C
Journal of leukocyte biology 2018 Nov;104(5):969-985

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Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications.

Torossian F, Guerton B, Anginot A, Alexander KA, Desterke C, Soave S, Tseng HW, Arouche N, Boutin L, Kulina I, Salga M, Jose B, Pettit AR, Clay D, Rochet N, Vlachos E, Genet G, Debaud C, Denormandie P, Genet F, Sims NA, Banzet S, Levesque JP, Lataillade JJ, Le Bousse-Kerdilès MC
JCI insight 2017 Nov 2;2(21)

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Osteopontin Promotes Oncostatin M Production in Human Osteoblasts: Implication of Rheumatoid Arthritis Therapy.

Su CM, Chiang YC, Huang CY, Hsu CJ, Fong YC, Tang CH
Journal of immunology (Baltimore, Md. : 1950) 2015 Oct 1;195(7):3355-64

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Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation.

Nicolaidou V, Wong MM, Redpath AN, Ersek A, Baban DF, Williams LM, Cope AP, Horwood NJ
PloS one 2012;7(7):e39871

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Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis.

Morrison C, Mancini S, Cipollone J, Kappelhoff R, Roskelley C, Overall C
The Journal of biological chemistry 2011 Sep 30;286(39):34271-85

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Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells.

Duluc D, Delneste Y, Tan F, Moles MP, Grimaud L, Lenoir J, Preisser L, Anegon I, Catala L, Ifrah N, Descamps P, Gamelin E, Gascan H, Hebbar M, Jeannin P
Blood 2007 Dec 15;110(13):4319-30

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Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells.

Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA
Journal of immunology (Baltimore, Md. : 1950) 2002 Nov 1;169(9):5244-51

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Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells.

Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA
Journal of immunology (Baltimore, Md. : 1950) 2002 Nov 1;169(9):5244-51