ABIN358674

antibody from antibodies-online

Targeting: MLLT3 AF-9, AF9, YEATS3

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN358674

Provider

antibodies-online

Product name

anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) (Middle Region) antibody

Antibody type

Polyclonal

Description

Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

Reactivity

Human

Host

Rabbit

Epitope

Middle Region

Vial size

0.4 mL

Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis.

Strissel PL, Strick R, Tomek RJ, Roe BA, Rowley JD, Zeleznik-Le NJ
Human molecular genetics 2000 Jul 1;9(11):1671-9

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MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13.

Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R
Oncogene 1993 Nov;8(11):3085-92

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Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC
Proceedings of the National Academy of Sciences of the United States of America 1993 May 15;90(10):4631-5