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LearnABIN400971
antibody from antibodies-online
Targeting: DIABLO
DFNA64, DIABLO-S, FLJ10537, FLJ25049, SMAC
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations [0]
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- Product number
- ABIN400971 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) (AA 56-239), (His6) antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant His6-tagged human Smac/DIABLO protein (amino acids 56-239)
- Description
- Serum
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- AA 56-239,His6
- Isotype
- IgG
- Vial size
- 0.1 mL
- Concentration
- 85 mg/mL (by Refractometry)
- Storage
- Store the antibody at 2°C to 8°C up to one month or (in aliquots) at -20°C to -70°C for longer.
- Handling
- Avoid repeated freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
Submitted references Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs.
Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.
Structural basis of IAP recognition by Smac/DIABLO.
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
Structural and biochemical basis of apoptotic activation by Smac/DIABLO.
Verhagen AM, Coulson EJ, Vaux DL
Genome biology 2001;2(7):REVIEWS3009
Genome biology 2001;2(7):REVIEWS3009
Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
Srinivasula SM, Datta P, Fan XJ, Fernandes-Alnemri T, Huang Z, Alnemri ES
The Journal of biological chemistry 2000 Nov 17;275(46):36152-7
The Journal of biological chemistry 2000 Nov 17;275(46):36152-7
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.
Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL
Cell 2000 Jul 7;102(1):43-53
Cell 2000 Jul 7;102(1):43-53
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.
Du C, Fang M, Li Y, Li L, Wang X
Cell 2000 Jul 7;102(1):33-42
Cell 2000 Jul 7;102(1):33-42
Structural basis of IAP recognition by Smac/DIABLO.
Wu G, Chai J, Suber TL, Wu JW, Du C, Wang X, Shi Y
Nature 2000 Dec 21-28;408(6815):1008-12
Nature 2000 Dec 21-28;408(6815):1008-12
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC, Fesik SW
Nature 2000 Dec 21-28;408(6815):1004-8
Nature 2000 Dec 21-28;408(6815):1004-8
Structural and biochemical basis of apoptotic activation by Smac/DIABLO.
Chai J, Du C, Wu JW, Kyin S, Wang X, Shi Y
Nature 2000 Aug 24;406(6798):855-62
Nature 2000 Aug 24;406(6798):855-62
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