ABIN371649
antibody from antibodies-online
Targeting: DIABLO
DFNA64, DIABLO-S, FLJ10537, FLJ25049, SMAC
Antibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations [0]
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- Product number
- ABIN371649 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) antibody
- Antibody type
- Monoclonal
- Description
- Purified
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 2D12
- Vial size
- 0.1 mg
- Storage
- Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.Shelf life: one year from despatch.
Submitted references Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO.
DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9.
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2.
Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.
Hu S, Yang X
The Journal of biological chemistry 2003 Mar 21;278(12):10055-60
The Journal of biological chemistry 2003 Mar 21;278(12):10055-60
DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9.
Ekert PG, Silke J, Hawkins CJ, Verhagen AM, Vaux DL
The Journal of cell biology 2001 Feb 5;152(3):483-90
The Journal of cell biology 2001 Feb 5;152(3):483-90
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2.
Adrain C, Creagh EM, Martin SJ
The EMBO journal 2001 Dec 3;20(23):6627-36
The EMBO journal 2001 Dec 3;20(23):6627-36
Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
Srinivasula SM, Datta P, Fan XJ, Fernandes-Alnemri T, Huang Z, Alnemri ES
The Journal of biological chemistry 2000 Nov 17;275(46):36152-7
The Journal of biological chemistry 2000 Nov 17;275(46):36152-7
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.
Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL
Cell 2000 Jul 7;102(1):43-53
Cell 2000 Jul 7;102(1):43-53
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.
Du C, Fang M, Li Y, Li L, Wang X
Cell 2000 Jul 7;102(1):33-42
Cell 2000 Jul 7;102(1):33-42
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