ABIN371649

antibody from antibodies-online

Targeting: DIABLO DFNA64, DIABLO-S, FLJ10537, FLJ25049, SMAC

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN371649

Provider

antibodies-online

Product name

anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) antibody

Antibody type

Monoclonal

Description

Purified

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

2D12

Vial size

0.1 mg

Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.Shelf life: one year from despatch.

References

Submitted references

Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO.

Hu S, Yang X
The Journal of biological chemistry 2003 Mar 21;278(12):10055-60

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DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9.

Ekert PG, Silke J, Hawkins CJ, Verhagen AM, Vaux DL
The Journal of cell biology 2001 Feb 5;152(3):483-90

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Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2.

Adrain C, Creagh EM, Martin SJ
The EMBO journal 2001 Dec 3;20(23):6627-36

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Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.

Srinivasula SM, Datta P, Fan XJ, Fernandes-Alnemri T, Huang Z, Alnemri ES
The Journal of biological chemistry 2000 Nov 17;275(46):36152-7

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.

Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL
Cell 2000 Jul 7;102(1):43-53

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.

Du C, Fang M, Li Y, Li L, Wang X
Cell 2000 Jul 7;102(1):33-42