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LearnNB100-56311
antibody from Novus Biologicals
Targeting: DIABLO
DFNA64, DIABLO-S, FLJ10537, FLJ25049, SMAC
Western blot
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- NB100-56311 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-56311, RRID:AB_838880
- Product name
- Rabbit Polyclonal SMAC/Diablo Antibody
- Antibody type
- Polyclonal
- Description
- Protein G purified. Smac
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 0.5 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references An apoptosis-independent role of SMAC in tumor suppression.
Clinical significance of Smac/DIABLO expression in colorectal cancer.
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation.
Activation of dual apoptotic pathways in human melanocytes and protection by survivin.
Expression of Smac/DIABLO in B-cell non-Hodgkin and Hodgkin lymphomas.
Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells.
7-Ketocholesterol-induced apoptosis. Involvement of several pro-apoptotic but also anti-apoptotic calcium-dependent transduction pathways.
Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells.
Downregulation of Smac/DIABLO expression in renal cell carcinoma and its prognostic significance.
Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death.
Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells.
p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas.
PR39 inhibits apoptosis in hypoxic endothelial cells: role of inhibitor apoptosis protein-2.
Phospholipid scramblase 3 controls mitochondrial structure, function, and apoptotic response.
Immunohistochemical analysis of Smac/DIABLO expression in human carcinomas and sarcomas.
Immunohistochemical analysis of Smac/DIABLO expression in human carcinomas and sarcomas.
SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP).
Qiu W, Liu H, Sebastini A, Sun Q, Wang H, Zhang L, Yu J
Oncogene 2013 May 9;32(19):2380-9
Oncogene 2013 May 9;32(19):2380-9
Clinical significance of Smac/DIABLO expression in colorectal cancer.
Endo K, Kohnoe S, Watanabe A, Tashiro H, Sakata H, Morita M, Kakeji Y, Maehara Y
Oncology reports 2009 Feb;21(2):351-5
Oncology reports 2009 Feb;21(2):351-5
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation.
Conus S, Perozzo R, Reinheckel T, Peters C, Scapozza L, Yousefi S, Simon HU
The Journal of experimental medicine 2008 Mar 17;205(3):685-98
The Journal of experimental medicine 2008 Mar 17;205(3):685-98
Activation of dual apoptotic pathways in human melanocytes and protection by survivin.
Liu T, Biddle D, Hanks AN, Brouha B, Yan H, Lee RM, Leachman SA, Grossman D
The Journal of investigative dermatology 2006 Oct;126(10):2247-56
The Journal of investigative dermatology 2006 Oct;126(10):2247-56
Expression of Smac/DIABLO in B-cell non-Hodgkin and Hodgkin lymphomas.
Ren Y, Akyurek N, Schlette E, Rassidakis GZ, Medeiros LJ
Human pathology 2006 Nov;37(11):1407-13
Human pathology 2006 Nov;37(11):1407-13
Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells.
Lee JC, Lee CH, Su CL, Huang CW, Liu HS, Lin CN, Won SJ
Carcinogenesis 2005 Oct;26(10):1716-30
Carcinogenesis 2005 Oct;26(10):1716-30
7-Ketocholesterol-induced apoptosis. Involvement of several pro-apoptotic but also anti-apoptotic calcium-dependent transduction pathways.
Berthier A, Lemaire-Ewing S, Prunet C, Montange T, Vejux A, Pais de Barros JP, Monier S, Gambert P, Lizard G, Néel D
The FEBS journal 2005 Jun;272(12):3093-104
The FEBS journal 2005 Jun;272(12):3093-104
Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells.
Qin JZ, Ziffra J, Stennett L, Bodner B, Bonish BK, Chaturvedi V, Bennett F, Pollock PM, Trent JM, Hendrix MJ, Rizzo P, Miele L, Nickoloff BJ
Cancer research 2005 Jul 15;65(14):6282-93
Cancer research 2005 Jul 15;65(14):6282-93
Downregulation of Smac/DIABLO expression in renal cell carcinoma and its prognostic significance.
Mizutani Y, Nakanishi H, Yamamoto K, Li YN, Matsubara H, Mikami K, Okihara K, Kawauchi A, Bonavida B, Miki T
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005 Jan 20;23(3):448-54
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005 Jan 20;23(3):448-54
Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death.
Hu P, Han Z, Couvillon AD, Exton JH
The Journal of biological chemistry 2004 Nov 19;279(47):49420-9
The Journal of biological chemistry 2004 Nov 19;279(47):49420-9
Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells.
Liu T, Brouha B, Grossman D
Oncogene 2004 Jan 8;23(1):39-48
Oncogene 2004 Jan 8;23(1):39-48
p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas.
Qin JZ, Stennett L, Bacon P, Bodner B, Hendrix MJ, Seftor RE, Seftor EA, Margaryan NV, Pollock PM, Curtis A, Trent JM, Bennett F, Miele L, Nickoloff BJ
Molecular cancer therapeutics 2004 Aug;3(8):895-902
Molecular cancer therapeutics 2004 Aug;3(8):895-902
PR39 inhibits apoptosis in hypoxic endothelial cells: role of inhibitor apoptosis protein-2.
Wu J, Parungo C, Wu G, Kang PM, Laham RJ, Sellke FW, Simons M, Li J
Circulation 2004 Apr 6;109(13):1660-7
Circulation 2004 Apr 6;109(13):1660-7
Phospholipid scramblase 3 controls mitochondrial structure, function, and apoptotic response.
Liu J, Dai Q, Chen J, Durrant D, Freeman A, Liu T, Grossman D, Lee RM
Molecular cancer research : MCR 2003 Oct;1(12):892-902
Molecular cancer research : MCR 2003 Oct;1(12):892-902
Immunohistochemical analysis of Smac/DIABLO expression in human carcinomas and sarcomas.
Yoo NJ, Kim HS, Kim SY, Park WS, Park CH, Jeon H, Jung ES, Lee JY, Lee SH
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003 Mar;111(3):382-8
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003 Mar;111(3):382-8
Immunohistochemical analysis of Smac/DIABLO expression in human carcinomas and sarcomas.
Yoo NJ, Kim HS, Kim SY, Park WS, Park CH, Jeon H, Jung ES, Lee JY, Lee SH
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003 Mar;111(3):382-8
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003 Mar;111(3):382-8
SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP).
Vucic D, Deshayes K, Ackerly H, Pisabarro MT, Kadkhodayan S, Fairbrother WJ, Dixit VM
The Journal of biological chemistry 2002 Apr 5;277(14):12275-9
The Journal of biological chemistry 2002 Apr 5;277(14):12275-9
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: SMAC/Diablo Antibody [NB100-56311] - Analysis of Smac (DIABLO) in HeLa lysate using Smac antibody at 2 ug/ml.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: SMAC/Diablo Antibody [NB100-56311] - Analysis of human prostate using Smac antibody at 10 ug/ml.
