Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations [0]
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- Product number
- 513501 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#513501, RRID:AB_2124018
- Product name
- Purified anti-human IL-32
- Antibody type
- Monoclonal
- Antigen
- Recombinant human IL-32α
- Description
- Interleukin 32 (IL-32),previously known as a transcript (NK4), is produced by mitogen-activated lymphocytes, by IFNγ-activated epithelial cells or by IL-12 and IL-18-activated NK cells.Its expression is increased following activation of T-cells by mitogens or the activation of NK cells by IL-2.IL-32 activates NF-κ-B and p38 MAPK cytokine signal pathways. It has been suggested that IL-32 may play a role in autoimmune and inflammatory diseases such as rheumatoid arthritis.IL-32 is unusual in that it does not share sequence homology with known cytokine families and is highly expressed in immune tissues. IL-32 exists in at least four differentially spliced isoforms (α, β, γ and δ)with predicted molecular weight: ~26 kD.IL-32α is the shortest and most abundant of four potential splice variants of the pro-inflammatory cytokine IL-32.Potential modifications include myristoylation and N-glycosylation. Transfected IL-32 alpha was more likely to be cell-associated as compared to IL-32β, suggesting an intracellular function.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 50 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Regulation and expression of IL-32 in chronic rhinosinusitis.
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection.
Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease.
Soyka MB, Treis A, Eiwegger T, Menz G, Zhang S, Holzmann D, Akdis CA, Meyer N
Allergy 2012 Jun;67(6):790-8
Allergy 2012 Jun;67(6):790-8
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection.
Li W, Sun W, Liu L, Yang F, Li Y, Chen Y, Fang J, Zhang W, Wu J, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2010 Nov 1;185(9):5056-65
Journal of immunology (Baltimore, Md. : 1950) 2010 Nov 1;185(9):5056-65
Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease.
Greene CM, Low TB, O'Neill SJ, McElvaney NG
American journal of respiratory and critical care medicine 2010 Jan 1;181(1):31-5
American journal of respiratory and critical care medicine 2010 Jan 1;181(1):31-5
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