Antibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations [0]
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- Product number
- AF3040 - Provider product page
- Provider
- R&D Systems
- Product name
- Human IL-32 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects human IL-32 in direct ELISAs and Western blots.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
NP_001012651
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Genetic variant in IL-32 is associated with the ex vivo cytokine production of anti-TNF treated PBMCs from rheumatoid arthritis patients.
Allele-specific long-distance regulation dictates IL-32 isoform switching and mediates susceptibility to HIV-1.
Interleukin (IL)-32β-mediated CCAAT/enhancer-binding protein α (C/EBPα) phosphorylation by protein kinase Cδ (PKCδ) abrogates the inhibitory effect of C/EBPα on IL-10 production.
Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation.
Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model.
Inflammation-dependent secretion and splicing of IL-32{gamma} in rheumatoid arthritis.
Native IL-32 is released from intestinal epithelial cells via a non-classical secretory pathway as a membrane-associated protein.
Protection from RNA and DNA viruses by IL-32.
Interleukin-32 expression in the pancreas.
Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease.
Damen MSMA, Schraa K, Tweehuysen L, den Broeder AA, Netea MG, Popa CD, Joosten LAB
Scientific reports 2018 Sep 19;8(1):14050
Scientific reports 2018 Sep 19;8(1):14050
Allele-specific long-distance regulation dictates IL-32 isoform switching and mediates susceptibility to HIV-1.
Palstra RJ, de Crignis E, Röling MD, van Staveren T, Kan TW, van Ijcken W, Mueller YM, Katsikis PD, Mahmoudi T
Science advances 2018 Feb;4(2):e1701729
Science advances 2018 Feb;4(2):e1701729
Interleukin (IL)-32β-mediated CCAAT/enhancer-binding protein α (C/EBPα) phosphorylation by protein kinase Cδ (PKCδ) abrogates the inhibitory effect of C/EBPα on IL-10 production.
Kang JW, Park YS, Kim MS, Lee DH, Bak Y, Ham SY, Park SH, Hong JT, Yoon DY
The Journal of biological chemistry 2013 Aug 16;288(33):23650-8
The Journal of biological chemistry 2013 Aug 16;288(33):23650-8
Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation.
Sakitani K, Hirata Y, Hayakawa Y, Serizawa T, Nakata W, Takahashi R, Kinoshita H, Sakamoto K, Nakagawa H, Akanuma M, Yoshida H, Maeda S, Koike K
Infection and immunity 2012 Nov;80(11):3795-803
Infection and immunity 2012 Nov;80(11):3795-803
Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model.
Marcondes AM, Li X, Tabellini L, Bartenstein M, Kabacka J, Sale GE, Hansen JA, Dinarello CA, Deeg HJ
Blood 2011 Nov 3;118(18):5031-9
Blood 2011 Nov 3;118(18):5031-9
Inflammation-dependent secretion and splicing of IL-32{gamma} in rheumatoid arthritis.
Heinhuis B, Koenders MI, van de Loo FA, Netea MG, van den Berg WB, Joosten LA
Proceedings of the National Academy of Sciences of the United States of America 2011 Mar 22;108(12):4962-7
Proceedings of the National Academy of Sciences of the United States of America 2011 Mar 22;108(12):4962-7
Native IL-32 is released from intestinal epithelial cells via a non-classical secretory pathway as a membrane-associated protein.
Hasegawa H, Thomas HJ, Schooley K, Born TL
Cytokine 2011 Jan;53(1):74-83
Cytokine 2011 Jan;53(1):74-83
Protection from RNA and DNA viruses by IL-32.
Zepp JA, Nold-Petry CA, Dinarello CA, Nold MF
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 1;186(7):4110-8
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 1;186(7):4110-8
Interleukin-32 expression in the pancreas.
Nishida A, Andoh A, Inatomi O, Fujiyama Y
The Journal of biological chemistry 2009 Jun 26;284(26):17868-76
The Journal of biological chemistry 2009 Jun 26;284(26):17868-76
Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease.
Shioya M, Nishida A, Yagi Y, Ogawa A, Tsujikawa T, Kim-Mitsuyama S, Takayanagi A, Shimizu N, Fujiyama Y, Andoh A
Clinical and experimental immunology 2007 Sep;149(3):480-6
Clinical and experimental immunology 2007 Sep;149(3):480-6
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