RP1026

antibody from Boster Biological Technology

Targeting: BIRC5 API4, EPR-1, survivin

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

RP1026

Provider

Boster Biological Technology

Product name

Anti-survivin/BIRC5 Antibody

Antibody type

Polyclonal

Description

Polyclonal antibody for 536 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: ELISA. Reactive species: Human. 536 information: Molecular Weight: 16389 MW; Subcellular Localization: Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1- mediated nuclear export; Tissue Specificity: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.

Reactivity

Human

Host

Rabbit

Vial size

100μg/vial

Concentration

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Handling

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

References

Submitted references

Isolation of an "Early" Transit Amplifying Keratinocyte Population in Human Epidermis: A Role for the Low Affinity Neurotrophin Receptor CD271.

Lotti R, Palazzo E, Quadri M, Dumas M, Schnebert S, Biondini D, Bianchini MA, Nizard C, Pincelli C, Marconi A
Stem cells (Dayton, Ohio) 2022 Dec 31;40(12):1149-1161

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Effect of 5-aminolevulinic acid photodynamic therapy on the expression of apoptosis inhibitors Bcl-2 and Survivin in keratinocytes of condyloma acuminatum.

Yin G, Li X, Wang X, Zhang H
Photodiagnosis and photodynamic therapy 2019 Dec;28:53-57

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Kallistatin, a novel anti-angiogenesis agent, inhibits angiogenesis via inhibition of the NF-κB signaling pathway.

Huang KF, Huang XP, Xiao GQ, Yang HY, Lin JS, Diao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2014 May;68(4):455-61

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Aspirin overcomes Navitoclax-resistance in hepatocellular carcinoma cells through suppression of Mcl-1.

Li G, Zhang S, Fang H, Yan B, Zhao Y, Feng L, Ma X, Ye X
Biochemical and biophysical research communications 2013 May 17;434(4):809-14

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Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction.

Rasul A, Bao R, Malhi M, Zhao B, Tsuji I, Li J, Li X
Molecules (Basel, Switzerland) 2013 Jan 24;18(2):1418-33

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Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis.

Tang C, Lu YH, Xie JH, Wang F, Zou JN, Yang JS, Xing YY, Xi T
Anti-cancer drugs 2009 Apr;20(4):249-58

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Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China.

Fang W, Li X, Jiang Q, Liu Z, Yang H, Wang S, Xie S, Liu Q, Liu T, Huang J, Xie W, Li Z, Zhao Y, Wang E, Marincola FM, Yao K
Journal of translational medicine 2008 Jun 20;6:32