Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 10787-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10787-1-AP, RRID:AB_2164476
- Product name
- Prohibitin antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Prohibitin antibody (Cat. #10787-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A mutation in the low-complexity domain of splicing factor hnRNPA1 linked to amyotrophic lateral sclerosis disrupts distinct neuronal RNA splicing networks.
Flt3 Activation Mitigates Mitochondrial Fragmentation and Heart Dysfunction through Rebalanced L-OPA1 Processing by Hindering the Interaction between Acetylated p53 and PHB2 in Cardiac Remodeling.
Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury.
APEX2-Mediated Proximity Labeling Resolves the DDIT4-Interacting Proteome.
Prohibitin 1 regulates mtDNA release and downstream inflammatory responses.
DJ-1 Deficiency in Hepatocytes Improves Liver Ischemia-Reperfusion Injury by Enhancing Mitophagy.
Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway.
Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress.
Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors.
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis.
Regulatory effects of Prohibitin 1 on proliferation and apoptosis of pulmonary arterial smooth muscle cells in monocrotaline-induced PAH rats.
Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P(2) and extended synaptotagmins.
IFN-γ restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer.
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.
NAD(+) repletion inhibits the endothelial-to-mesenchymal transition induced by TGF-β in endothelial cells through improving mitochondrial unfolded protein response.
Cholix toxin, an eukaryotic elongation factor 2 ADP-ribosyltransferase, interacts with Prohibitins and induces apoptosis with mitochondrial dysfunction in human hepatocytes.
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
Antiosteoporotic Effects of Huangqi Sanxian Decoction in Cultured Rat Osteoblasts by Proteomic Characterization of the Target and Mechanism.
Cholesterol transport through lysosome-peroxisome membrane contacts.
A comparative proteomic study identified calreticulin and prohibitin up-regulated in adrenocortical carcinomas.
Identification of human host proteins contributing to H5N1 influenza virus propagation by membrane proteomics.
Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation.
Lee YJ, Rio DC
Genes & development 2024 Feb 13;38(1-2):11-30
Genes & development 2024 Feb 13;38(1-2):11-30
Flt3 Activation Mitigates Mitochondrial Fragmentation and Heart Dysfunction through Rebalanced L-OPA1 Processing by Hindering the Interaction between Acetylated p53 and PHB2 in Cardiac Remodeling.
Zhang K, Zheng Y, Bao G, Ma W, Han B, Shi H, Zhao Z
Antioxidants (Basel, Switzerland) 2023 Aug 22;12(9)
Antioxidants (Basel, Switzerland) 2023 Aug 22;12(9)
Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury.
Chen L, Dong J, Liao S, Wang S, Wu Z, Zuo M, Liu B, Yan C, Chen Y, He H, Meng Q, Song Z
Hepatology (Baltimore, Md.) 2022 Nov;76(5):1389-1408
Hepatology (Baltimore, Md.) 2022 Nov;76(5):1389-1408
APEX2-Mediated Proximity Labeling Resolves the DDIT4-Interacting Proteome.
Naki M, Gourdomichali O, Zonke K, Kattan FG, Makridakis M, Kontostathi G, Vlahou A, Doxakis E
International journal of molecular sciences 2022 May 6;23(9)
International journal of molecular sciences 2022 May 6;23(9)
Prohibitin 1 regulates mtDNA release and downstream inflammatory responses.
Liu H, Fan H, He P, Zhuang H, Liu X, Chen M, Zhong W, Zhang Y, Zhen C, Li Y, Jiang H, Meng T, Xu Y, Zhao G, Feng D
The EMBO journal 2022 Dec 15;41(24):e111173
The EMBO journal 2022 Dec 15;41(24):e111173
DJ-1 Deficiency in Hepatocytes Improves Liver Ischemia-Reperfusion Injury by Enhancing Mitophagy.
Xu M, Hang H, Huang M, Li J, Xu D, Jiao J, Wang F, Wu H, Sun X, Gu J, Kong X, Gao Y
Cellular and molecular gastroenterology and hepatology 2021;12(2):567-584
Cellular and molecular gastroenterology and hepatology 2021;12(2):567-584
Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway.
Ma J, Shi Q, Guo S, Xu P, Yi X, Yang Y, Zhang W, Liu Y, Liu L, Yue Q, Zhao T, Gao T, Guo W, Li C
Frontiers in oncology 2021;11:818178
Frontiers in oncology 2021;11:818178
Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress.
Wu L, Wang Q, Guo F, Ma X, Wang J, Zhao Y, Yan Y, Qin G
Journal of cellular physiology 2021 Feb;236(2):1454-1468
Journal of cellular physiology 2021 Feb;236(2):1454-1468
Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors.
Dennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P
eLife 2021 Dec 31;10
eLife 2021 Dec 31;10
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis.
Yan C, Gong L, Chen L, Xu M, Abou-Hamdan H, Tang M, Désaubry L, Song Z
Autophagy 2020 Mar;16(3):419-434
Autophagy 2020 Mar;16(3):419-434
Regulatory effects of Prohibitin 1 on proliferation and apoptosis of pulmonary arterial smooth muscle cells in monocrotaline-induced PAH rats.
Cao YY, Ba HX, Li Y, Tang SY, Luo ZQ, Li XH
Life sciences 2020 Jun 1;250:117548
Life sciences 2020 Jun 1;250:117548
Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P(2) and extended synaptotagmins.
Xiao J, Luo J, Hu A, Xiao T, Li M, Kong Z, Jiang L, Zhou Z, Liao Y, Xie C, Chu B, Miao H, Li B, Shi X, Song BL
Science China. Life sciences 2019 Sep;62(9):1117-1135
Science China. Life sciences 2019 Sep;62(9):1117-1135
IFN-γ restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer.
Yin H, Jiang Z, Wang S, Zhang P
Cell death & disease 2019 Sep 9;10(9):642
Cell death & disease 2019 Sep 9;10(9):642
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.
Han Y, Wu P, Wang Z, Zhang Z, Sun S, Liu J, Gong S, Gao P, Iwakuma T, Molina-Vila MA, Chen BP, Zhang Y, Ji T, Mo Q, Chen P, Hu J, Wang S, Zhou J, Lu H, Gao Q
EBioMedicine 2019 Feb;40:92-105
EBioMedicine 2019 Feb;40:92-105
NAD(+) repletion inhibits the endothelial-to-mesenchymal transition induced by TGF-β in endothelial cells through improving mitochondrial unfolded protein response.
Zhang M, Weng H, Zheng J
The international journal of biochemistry & cell biology 2019 Dec;117:105635
The international journal of biochemistry & cell biology 2019 Dec;117:105635
Cholix toxin, an eukaryotic elongation factor 2 ADP-ribosyltransferase, interacts with Prohibitins and induces apoptosis with mitochondrial dysfunction in human hepatocytes.
Yahiro K, Ogura K, Terasaki Y, Satoh M, Miyagi S, Terasaki M, Yamasaki E, Moss J
Cellular microbiology 2019 Aug;21(8):e13033
Cellular microbiology 2019 Aug;21(8):e13033
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z
Cell death and differentiation 2016 Mar;23(3):380-92
Cell death and differentiation 2016 Mar;23(3):380-92
Antiosteoporotic Effects of Huangqi Sanxian Decoction in Cultured Rat Osteoblasts by Proteomic Characterization of the Target and Mechanism.
Guo CC, Zheng LH, Fu JY, Zhu JH, Zhou YX, Zeng T, Zhou ZK
Evidence-based complementary and alternative medicine : eCAM 2015;2015:514063
Evidence-based complementary and alternative medicine : eCAM 2015;2015:514063
Cholesterol transport through lysosome-peroxisome membrane contacts.
Chu BB, Liao YC, Qi W, Xie C, Du X, Wang J, Yang H, Miao HH, Li BL, Song BL
Cell 2015 Apr 9;161(2):291-306
Cell 2015 Apr 9;161(2):291-306
A comparative proteomic study identified calreticulin and prohibitin up-regulated in adrenocortical carcinomas.
Yang MS, Wang HS, Wang BS, Li WH, Pang ZF, Zou BK, Zhang X, Shi XT, Mu DB, Zhang DX, Gao YS, Sun XW, Xia SJ
Diagnostic pathology 2013 Apr 15;8:58
Diagnostic pathology 2013 Apr 15;8:58
Identification of human host proteins contributing to H5N1 influenza virus propagation by membrane proteomics.
Liu C, Zhang A, Guo J, Yang J, Zhou H, Chen H, Jin M
Journal of proteome research 2012 Nov 2;11(11):5396-405
Journal of proteome research 2012 Nov 2;11(11):5396-405
Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation.
McCray BA, Skordalakes E, Taylor JP
Human molecular genetics 2010 Mar 15;19(6):1033-47
Human molecular genetics 2010 Mar 15;19(6):1033-47
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10787-1-AP(PHB antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Prohibitin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Prohibitin. This antibody recognizes human,mouse,rat antigen. The Prohibitin antibody has been validated for the following applications: ELISA, IHC, WB, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 10787-1-AP(PHB antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 10787-1-AP(PHB antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue