Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 603102 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#603102, RRID:AB_2164630
- Product name
- Purified anti-Prohibitin
- Antibody type
- Polyclonal
- Antigen
- Recombinant (partial), C-terminal
- Description
- Prohibitin is a 30 kD member of the band 7 family containing a SPFH domain. Prohibitin is localized the nucleus and mitochondrial inner cell membrane. This protein functions as a negative regulator of cell proliferation associated with senescence and cell death and a transcriptional repressor via recruitment of Brg-1, Brm or N-CoR, or HDAC1. Prohibitin can also function as a membrane-bound chaperone for the assembly of the mitochondrial respiratory chain complex. Prohibitin is induced by metabolic stress caused by imbalance in synthesis of mitochondrial-, nuclear-encoded mitochondrial proteins. Prohibitin can be modified by phosphorylation and ubiquitination. This protein has been shown to interact with Rb, Brg-1, Brm, N-CoR, HDAC1, and PHB2. The Poly6031 antibody recognizes the C-terminal region of human prohibitin and has been shown to be useful for Western blotting.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Vial size
- 200 µl
- Storage
- Upon receipt, store frozen at -20° C.
Submitted references Human C4orf14 interacts with the mitochondrial nucleoid and is involved in the biogenesis of the small mitochondrial ribosomal subunit.
Rescue of paclitaxel sensitivity by repression of Prohibitin1 in drug-resistant cancer cells.
Up-regulation of the peroxiredoxin-6 related metabolism of reactive oxygen species in skeletal muscle of mice lacking neuronal nitric oxide synthase.
Coupling of the de novo fatty acid biosynthesis and lipoylation pathways in mammalian mitochondria.
He J, Cooper HM, Reyes A, Di Re M, Kazak L, Wood SR, Mao CC, Fearnley IM, Walker JE, Holt IJ
Nucleic acids research 2012 Jul 1;40(13):6097-108
Nucleic acids research 2012 Jul 1;40(13):6097-108
Rescue of paclitaxel sensitivity by repression of Prohibitin1 in drug-resistant cancer cells.
Patel N, Chatterjee SK, Vrbanac V, Chung I, Mu CJ, Olsen RR, Waghorne C, Zetter BR
Proceedings of the National Academy of Sciences of the United States of America 2010 Feb 9;107(6):2503-8
Proceedings of the National Academy of Sciences of the United States of America 2010 Feb 9;107(6):2503-8
Up-regulation of the peroxiredoxin-6 related metabolism of reactive oxygen species in skeletal muscle of mice lacking neuronal nitric oxide synthase.
Da Silva-Azevedo L, Jähne S, Hoffmann C, Stalder D, Heller M, Pries AR, Zakrzewicz A, Baum O
The Journal of physiology 2009 Feb 1;587(Pt 3):655-68
The Journal of physiology 2009 Feb 1;587(Pt 3):655-68
Coupling of the de novo fatty acid biosynthesis and lipoylation pathways in mammalian mitochondria.
Witkowski A, Joshi AK, Smith S
The Journal of biological chemistry 2007 May 11;282(19):14178-85
The Journal of biological chemistry 2007 May 11;282(19):14178-85
No comments: Submit comment
No validations: Submit validation data