350703
antibody from BioLegend
Targeting: S100A9
60B8AG, CAGB, CFAG, CGLB, LIAG, MAC387, MIF, MRP14, NIF, P14
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 350703 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#350703, RRID:AB_10662414
- Product name
- FITC anti-human MRP-14 (S100A9)
- Antibody type
- Monoclonal
- Antigen
- Recombinant human MRP-14
- Description
- MRP-14, also known as S100A9, belongs to the S100 family of proteins containing 2-EF-hand calcium-binding motifs. It forms non-covalently associated complexes with another S100 family member, MRP-8. MRP14 is expressed in neutrophils and monocytes; it also has been found in ileal tissue eosinophils. The S100A8/A9 complex has been shown to play a role during calcium-dependent activation as well as have antibacterial, antifungal, immunomodulating, and anti-proliferative effects. It also functions as a chemoattractant factor for neutrophils and recently has been considered an endogenous activator of Toll-like receptor 4. A recent report has identified S100A9 as a marker for CD14(+) HLA-DR(-/low) MDSCs.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Green dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood granulocytes surface stained with anti-human CD15 PerCP/Cy5.5, then intracellularly stained with anti-human MRP14 (clone 1H9) FITC (top) or mouse IgG1 FITC isotype control (middle)
- Conjugate
- Green dye