Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60034 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- LSM1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human LSM1.
- Description
- Sm and Sm-like (LSm) proteins form donut-shaped heptameric complexes that are involved in various steps of RNA metabolism. LSm proteins facilitate RNA protein interactions and structural changes that are required during ribosomal subunit assembly. LSm1, also designated U6 snRNA-associated Sm-like protein or small nuclear ribonuclear CaSm, binds specifically to the 3'-terminal U-tract of U6 snRNA. Human LSm1 localizes to the cytoplasm in small, discrete foci. These foci are also the localization site for the mRNA decapping enzyme Dcp1/2 and the exonuclease Xm1. LSm1 is naturally overexpressed in pancreatic cancer as well as in certain breast cancer cell lines. The downregulation of LSm1 is involved in the progression of prostate cancer.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of LSM1 pAb at 1:500 dilutionLane1:Hela whole cell lysateLane2:HEK293T whole cell lysate