11250-1-AP

antibody from Proteintech Group

Targeting: S100A10 42C, ANX2LG, CAL1L, CLP11, P11

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

11250-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#11250-1-AP, RRID:AB_2269906

Product name

S100A10 antibody

Antibody type

Polyclonal

Description

KD/KO validated S100A10 antibody (Cat. #11250-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

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Astrocytic purinergic signalling contributes to the development and maintenance of neuropathic pain via modulation of glutamate release.

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Journal of neurochemistry 2024 Nov;168(11):3727-3744

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Effect of Myelin Debris on the Phenotypic Transformation of Astrocytes after Spinal Cord Injury in Rats.

Lv J, Yu H, Shan F, Ye J, Li A, Jing J, Zheng M, Tian D
Neuroscience 2024 May 24;547:1-16

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Fabry disease Schwann cells release p11 to induce sensory neuron hyperactivity.

Waltz TB, Chao D, Prodoehl EK, Enders JD, Ehlers VL, Dharanikota BS, Dahms NM, Isaeva E, Hogan QH, Pan B, Stucky CL
JCI insight 2024 Mar 7;9(8)

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Transformation of A1/A2 Astrocytes Participates in Brain Ischemic Tolerance Induced by Cerebral Ischemic Preconditioning via Inhibiting NDRG2.

Liu XH, Zhang LY, Liu XY, Zhang JG, Hu YY, Zhao CG, Xian XH, Li WB, Zhang M
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Astrocytic Extracellular Vesicles Regulated by Microglial Inflammatory Responses Improve Stroke Recovery.

Kijima C, Inaba T, Hira K, Miyamoto N, Yamashiro K, Urabe T, Hattori N, Ueno Y
Molecular neurobiology 2024 Feb;61(2):1002-1021

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Synergistic effects of tetramethylpyrazine and astragaloside IV on spinal cord injury via alteration of astrocyte A1/A2 polarization through the Sirt1-NF-κB pathway.

Rao Y, Li J, Qiao R, Luo J, Liu Y
International immunopharmacology 2024 Apr 20;131:111686

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Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10.

Nakamura Y, Ito MA, Hoshino Y, Matsuoka I, Okada T, Okada Y, Nakanishi T
American journal of physiology. Cell physiology 2024 Apr 1;326(4):C1042-C1053

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Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress.

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Frontiers in cellular neuroscience 2023;17:1136070

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miR-21-5p Inhibits the Proliferation, Migration, and Invasion of Glioma by Targeting S100A10.

Gao P, Wang H, Li H, Shu L, Han Z, Li S, Cheng H, Dai X
Journal of Cancer 2023;14(10):1781-1793

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Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity.

Kong S, Chen TX, Jia XL, Cheng XL, Zeng ML, Liang JY, He XH, Yin J, Han S, Liu WH, Fan YT, Zhou T, Liu YM, Peng BW
Journal of neuroinflammation 2023 Oct 25;20(1):247

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Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut-brain axis.

Guo X, Li C, Zhang J, Sun M, Xu J, Xu C, Kuang H, Xu L
Nature aging 2023 Nov;3(11):1415-1429

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Roles of prokineticin 2 in electroconvulsive shock-induced memory impairment via regulation of phenotype polarization in astrocytes.

Chen L, Lv F, Min S, Yang Y, Liu D
Behavioural brain research 2023 May 28;446:114350

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Schwann cell release of p11 induces sensory neuron hyperactivity in Fabry disease.

Waltz TB, Chao D, Prodoehl EK, Ehlers VL, Dharanikota BS, Dahms NM, Isaeva E, Hogan QH, Pan B, Stucky CL
bioRxiv : the preprint server for biology 2023 May 28;

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Bilirubin Induces A1-Like Reactivity of Astrocyte.

Li S, Huang H, Zhang Y, Li L, Hua Z
Neurochemical research 2023 Mar;48(3):804-815

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Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury.

Chang J, Qian Z, Wang B, Cao J, Zhang S, Jiang F, Kong R, Yu X, Cao X, Yang L, Chen H
Cell communication and signaling : CCS 2023 Feb 16;21(1):37

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Astrocytes and microglia-targeted Danshensu liposomes enhance the therapeutic effects on cerebral ischemia-reperfusion injury.

Bai M, Cui N, Liao Y, Guo C, Li L, Yin Y, Wen A, Wang J, Ye W, Ding Y
Journal of controlled release : official journal of the Controlled Release Society 2023 Dec;364:473-489

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Pregabalin inhibits purinergic P2Y(2) receptor and TRPV4 to suppress astrocyte activation and to relieve neuropathic pain.

Song S, Wang Q, Qu Y, Gao W, Li D, Xu X, Yue S
European journal of pharmacology 2023 Dec 5;960:176140

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The role of reactive astrocytes in neurotoxicity induced by ultrafine particulate matter.

Li B, Chang X, Liang X, Liu T, Shen Y, Zhang Q, Yang X, Lyu Y, Liu L, Guo J, Wu M, Gao Y, Yan X, Wang T, Zhang W, Qiu Y, Zheng J
The Science of the total environment 2023 Apr 1;867:161416

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NLRP3 inflammasome regulates astrocyte transformation in brain injury induced by chronic intermittent hypoxia.

She N, Shi Y, Feng Y, Ma L, Yuan Y, Zhang Y, Cao Z, Chen X, Zhao B, Liu H, Ren X
BMC neuroscience 2022 Nov 27;23(1):70

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Homer1 promotes the conversion of A1 astrocytes to A2 astrocytes and improves the recovery of transgenic mice after intracerebral hemorrhage.

Fei X, Dou YN, Wang L, Wu X, Huan Y, Wu S, He X, Lv W, Wei J, Fei Z
Journal of neuroinflammation 2022 Mar 14;19(1):67

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Ror2 mediates chronic post-thoracotomy pain by inducing the transformation of A1/A2 reactive astrocytes in rats.

Liu C, Shen L, Xu L, Zhu A, Huang Y
Cellular signalling 2022 Jan;89:110183

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S100A10 regulates tumor necrosis factor alpha-induced apoptosis in chondrocytes via the reactive oxygen species/nuclear factor-kappa B pathway.

Guo Y, Li R, Dang X
Biotechnology and applied biochemistry 2022 Dec;69(6):2284-2295

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Cornuside Is a Potential Agent against Alzheimer's Disease via Orchestration of Reactive Astrocytes.

Shi JZ, Zheng XM, Zhou YF, Yun LY, Luo DM, Hao JJ, Liu PF, Zhang WK, Xu JK, Yan Y, Xie XM, He YY, Pang XB
Nutrients 2022 Aug 3;14(15)

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The thrombin receptor modulates astroglia-neuron trophic coupling and neural repair after spinal cord injury.

Kim HN, Triplet EM, Radulovic M, Bouchal S, Kleppe LS, Simon WL, Yoon H, Scarisbrick IA
Glia 2021 Sep;69(9):2111-2132

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5α-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2.

Wei M, Zhou Y, Li C, Yang Y, Liu T, Liu Y, Wei Y, Liu N, Liu S, Wang Q, Cao S, Sun Y, Sheng P, Lu C, Yang C, Liu X, Yang G
Journal of medicinal chemistry 2021 Sep 9;64(17):12537-12547

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Extracellular vesicles derived from CD73 modified human umbilical cord mesenchymal stem cells ameliorate inflammation after spinal cord injury.

Zhai X, Chen K, Yang H, Li B, Zhou T, Wang H, Zhou H, Chen S, Zhou X, Wei X, Bai Y, Li M
Journal of nanobiotechnology 2021 Sep 8;19(1):274

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Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche.

He X, Smith SE, Chen S, Li H, Wu D, Meneses-Giles PI, Wang Y, Hembree M, Yi K, Zhao X, Guo F, Unruh JR, Maddera LE, Yu Z, Scott A, Perera A, Wang Y, Zhao C, Bae K, Box A, Haug JS, Tao F, Hu D, Hansen DM, Qian P, Saha S, Dixon D, Anant S, Zhang D, Lin EH, Sun W, Wiedemann LM, Li L
Cell reports 2021 Sep 7;36(10):109674

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Critical Role of Astrocyte NAD(+) Glycohydrolase in Myelin Injury and Regeneration.

Langley MR, Choi CI, Peclat TR, Guo Y, Simon WL, Yoon H, Kleppe L, Lucchinetti CF, Chini CCS, Chini EN, Scarisbrick IA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Oct 13;41(41):8644-8667

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Matrine treatment induced an A2 astrocyte phenotype and protected the blood-brain barrier in CNS autoimmunity.

Jing Y, Ma R, Chu Y, Dou M, Wang M, Li X, Zhu L
Journal of chemical neuroanatomy 2021 Nov;117:102004

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Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease.

Qu H, Gong X, Liu X, Zhang R, Wang Y, Huang B, Zhang L, Zheng H, Zheng Y
Diabetes 2021 Jun;70(6):1372-1387

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Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy.

Shao L, Jiang GT, Yang XL, Zeng ML, Cheng JJ, Kong S, Dong X, Chen TX, Han S, Yin J, Liu WH, He XH, He C, Peng BW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21330

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Differential and paradoxical roles of new-generation antidepressants in primary astrocytic inflammation.

He JH, Liu RP, Peng YM, Guo Q, Zhu LB, Lian YZ, Hu BL, Fan HH, Zhang X, Zhu JH
Journal of neuroinflammation 2021 Feb 18;18(1):47

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The effects of A1/A2 astrocytes on oligodendrocyte linage cells against white matter injury under prolonged cerebral hypoperfusion.

Miyamoto N, Magami S, Inaba T, Ueno Y, Hira K, Kijima C, Nakajima S, Yamashiro K, Urabe T, Hattori N
Glia 2020 Sep;68(9):1910-1924

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Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection.

Lou Y, Han M, Liu H, Niu Y, Liang Y, Guo J, Zhang W, Wang H
Cellular & molecular immunology 2020 Oct;17(10):1053-1062

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Blocking the Thrombin Receptor Promotes Repair of Demyelinated Lesions in the Adult Brain.

Yoon H, Choi CI, Triplet EM, Langley MR, Kleppe LS, Kim HN, Simon WL, Scarisbrick IA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Feb 12;40(7):1483-1500

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S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis.

Bharadwaj AG, Dahn ML, Liu RZ, Colp P, Thomas LN, Holloway RW, Marignani PA, Too CK, Barnes PJ, Godbout R, Marcato P, Waisman DM
Cancers 2020 Dec 7;12(12)

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Proteomic analysis of human periodontal ligament cells under hypoxia.

Li Q, Luo T, Lu W, Yi X, Zhao Z, Liu J
Proteome science 2019;17:3

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Down-regulation effects of IFN-α on p11, 5-htr1b and 5-HTR4 protein levels were affected by NH(4)CL or MG132 treatment in SH-sy5y cells.

Guo J, Ding H, Lv Z, Jiao J, Wang H, Ji Y
Journal of biosciences 2019 Sep;44(4)

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S100A10, a novel biomarker in pancreatic ductal adenocarcinoma.

Bydoun M, Sterea A, Liptay H, Uzans A, Huang WY, Rodrigues GJ, Weaver ICG, Gu H, Waisman DM
Molecular oncology 2018 Nov;12(11):1895-1916

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Probable involvement of p11 with interferon alpha induced depression.

Guo J, Zhang W, Zhang L, Ding H, Zhang J, Song C, Zhang Y, Xia N, Li M, Liang Y, Hu X, Luan H, Wang H
Scientific reports 2016 Jan 29;6:17029

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Label-free quantification proteomics reveals novel calcium binding proteins in matrix vesicles isolated from mineralizing Saos-2 cells.

Zhou X, Cui Y, Luan J, Zhou X, Zhang G, Zhang X, Han J
Bioscience trends 2013 Jun;7(3):144-51

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Feedback regulation of endothelial cell surface plasmin generation by PKC-dependent phosphorylation of annexin A2.

He KL, Sui G, Xiong H, Broekman MJ, Huang B, Marcus AJ, Hajjar KA
The Journal of biological chemistry 2011 Apr 29;286(17):15428-39

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse lung tissue were subjected to SDS PAGE followed by western blot with 11250-1-AP(S100A10 antibody) at dilution of 1:1000

Sample type

tissue

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of Hela cells, using S100A10 antibody 11250-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human pancreas cancer using 11250-1-AP(S100A10 antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Flow cytometry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The S100A10 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human S100A10. This antibody recognizes human,mouse,rat antigen. The S100A10 antibody has been validated for the following applications: ELISA, WB, IHC, IF, FC analysis.

Appendix

11250-1-AP.pdf

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