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- Antibody Data
- Antigen structure
- References [93]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- 11250-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11250-1-AP, RRID:AB_2269906
- Product name
- S100A10 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated S100A10 antibody (Cat. #11250-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ACSL4-mediated astrocyte ferroptosis augments neuroinflammation and exacerbates NMOSD pathology.
Astrocyte-Specific Nrf2 Expression Transforms Neurotoxic Reactive Astrocytes to Neuroprotective Phenotype in 3xTg-AD Mice.
MAFG Induces the Methylation of CRYAB to Promote the Activation of A1 Astrocyte After Spinal Cord Injury.
Mitochondrial Intercellular Transfer via Platelets After Physical Training Exerts Neuro-Glial Protection Against Cerebral Ischemia.
S100A10 promotes glycolysis and malignant progression of CCA by activating the HK2/ERK signaling pathway.
EGCG-loaded nanoparticles attenuate post-SAH white matter injury by targeting HO-1/S100A10 to suppress oxidative stress-induced reactive astrocytes.
Gut microbial ammonia as a mediator of PFOS neurotoxicity and its remediation by the flavonoid Icaritin.
Intermittent theta-burst stimulation promotes neurovascular unit remodeling after ischemic stroke in a mouse model.
Shh-S100A10 axis curbs neuronal PANoptosis after ischemic stroke.
YAP Regulates Microglial Anti-Inflammatory Responses and Alleviates Cognitive Impairment Through the IL-33/ST2 Pathway after Traumatic Brain Injury.
Targeting the HDAC4-NHE6-endosomal pH axis restores amyloid-β clearance and cognitive function in Alzheimer's disease mice.
Disruptions of p11 (S100A10) and HPA Axis Homeostasis Participate in the Major Depressive Disorder (MDD) Especially in Female Patients.
Astrocytic Ror2-induced imbalance in brain and gut homeostasis contributes to chronic post-thoracotomy pain.
Golexanolone affords sustained microglia and astrocytes activation improvement in a rat model of Parkinson's disease.
Targeting the miR-96-5p/Cathepsin B Pathway to Alleviate Neuron-Derived Neuroinflammation in Alzheimer's Disease.
Hypoxia-induced S100A10 promotes glioblastoma malignancy and chemoresistance by activating PI3K-AKT signaling pathway.
Echinacoside targets the HIF-1α/LDHA axis to modulate A1/A2 astrocyte differentiation and promote glial scar repair following ischemic stroke.
GRP78 alleviates secondary brain injury by regulating phenotype polarization in astrocytes via JAK2-STAT3 pathway after intracerebral hemorrhage.
Single-cell and spatial analyses reveal the effect of VSIG4(+)S100A10(+)TAMs on the immunosuppression of glioblastoma and anti-PD-1 immunotherapy.
SARM1 deletion inhibits astrogliosis and BBB damage through Jagged-1/Notch-1/NF-κB signaling to improve neurological function after ischemic stroke.
The roles of ROCK2/CBS-H(2)S pathway in the cerebral ischemia/reperfusion injury.
Effects of intermittent theta burst stimulation on the inflammatory response and cerebral blood flow in promoting neurovascular repair after ischemic stroke.
DL-3-n-butylphthalide inhibits astrocyte activation in the cortical penumbra of ischemia-reperfusion model rats via AKT signaling.
The role of Genipin crosslinked extracellular matrix loaded bFGF in the repair of peripheral nerve injury.
Cellular Landscape of Synovial Chondromatosis Synovium Revealed by Single-Cell RNA Sequencing.
Tracking astrocyte polarization in the retina in retinopathy of prematurity.
Study on the Polarization of Astrocytes in the Optic Nerve Head of Rats Under High Intraocular Pressure: In Vitro.
TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD.
Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration.
VEGFD/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3/microglia IL-3Rα cross-talk and drives neuroinflammation in mouse ischemic stroke.
Intra-cisterna-magna bevacizumab injection (ICM-BI) reproduces pathological alterations of cerebral small vessel diseases.
VNS facilitates the neurological function recovery after ischemia/reperfusion injury by regulating the A1/A2 polarization of astrocytes through the NMU-NMUR2 pathway.
The potential of taVNS in attenuating blood-brain barrier damage, promoting angiogenesis and improving impaired cognitive function in a rat model of vascular cognitive impairment and dementia by activating the Wnt7/β-catenin signaling pathway.
NEO1 modulates the A1 astrocyte polarization in subarachnoid hemorrhage through the cPLA2-MAVS signaling pathway.
Scutellarin Modulates Astrocyte-Microglia-Neuron Crosstalk to Mitigate Neuroinflammation and Apoptosis in Cerebral Ischemia.
Astrocyte-conditional knockout of MOB2 inhibits the phenotypic conversion of reactive astrocytes from A1 to A2 following spinal cord injury in mice.
Neuroimmune regulation of IFITM3 via γ-secretase in astrocytes during cerebral ischemia-reperfusion.
Exosome-shuttled miR-5121 from A2 astrocytes promotes BSCB repair after traumatic SCI by activating autophagy in vascular endothelial cells.
M1 Microglia-Derived Exosomes Promote A1 Astrocyte Activation and Aggravate Ischemic Injury via circSTRN3/miR-331-5p/MAVS/NF-κB Pathway.
Effect of NLRP3 inflammasome induced astrocyte phenotype alteration in morphine tolerance.
Exploring the effects of moxibustion on cognitive function in rats with multiple cerebral infarctions from the perspective of glial vascular unit repairing.
Montelukast improves disease outcome in SOD1(G93A) female mice by counteracting oligodendrocyte dysfunction and aberrant glial reactivity.
Withaferin A protects against epilepsy by promoting LCN2-mediated astrocyte polarization to stopping neuronal ferroptosis.
L-NRB alleviates amyotrophic lateral sclerosis by regulating P11-Htr4 signaling pathway.
Astrocytic purinergic signalling contributes to the development and maintenance of neuropathic pain via modulation of glutamate release.
Targeting resident astrocytes attenuates neuropathic pain after spinal cord injury.
Effect of Myelin Debris on the Phenotypic Transformation of Astrocytes after Spinal Cord Injury in Rats.
Fabry disease Schwann cells release p11 to induce sensory neuron hyperactivity.
Transformation of A1/A2 Astrocytes Participates in Brain Ischemic Tolerance Induced by Cerebral Ischemic Preconditioning via Inhibiting NDRG2.
Astrocytic Extracellular Vesicles Regulated by Microglial Inflammatory Responses Improve Stroke Recovery.
Runx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice.
The Phenotype Changes of Astrocyte During Different Ischemia Conditions.
A2 reactive astrocyte-derived exosomes alleviate cerebral ischemia-reperfusion injury by delivering miR-628.
Sciatic nerve stimulation alleviates neuropathic pain and associated neuroinflammation in the dorsal root ganglia in a rodent model.
Synergistic effects of tetramethylpyrazine and astragaloside IV on spinal cord injury via alteration of astrocyte A1/A2 polarization through the Sirt1-NF-κB pathway.
Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10.
The origins and dynamic changes of C3- and S100A10-positive reactive astrocytes after spinal cord injury.
Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress.
miR-21-5p Inhibits the Proliferation, Migration, and Invasion of Glioma by Targeting S100A10.
Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity.
Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut-brain axis.
Roles of prokineticin 2 in electroconvulsive shock-induced memory impairment via regulation of phenotype polarization in astrocytes.
Schwann cell release of p11 induces sensory neuron hyperactivity in Fabry disease.
Bilirubin Induces A1-Like Reactivity of Astrocyte.
Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury.
Astrocytes and microglia-targeted Danshensu liposomes enhance the therapeutic effects on cerebral ischemia-reperfusion injury.
Pregabalin inhibits purinergic P2Y(2) receptor and TRPV4 to suppress astrocyte activation and to relieve neuropathic pain.
The role of reactive astrocytes in neurotoxicity induced by ultrafine particulate matter.
NLRP3 inflammasome regulates astrocyte transformation in brain injury induced by chronic intermittent hypoxia.
Homer1 promotes the conversion of A1 astrocytes to A2 astrocytes and improves the recovery of transgenic mice after intracerebral hemorrhage.
Ror2 mediates chronic post-thoracotomy pain by inducing the transformation of A1/A2 reactive astrocytes in rats.
S100A10 regulates tumor necrosis factor alpha-induced apoptosis in chondrocytes via the reactive oxygen species/nuclear factor-kappa B pathway.
Cornuside Is a Potential Agent against Alzheimer's Disease via Orchestration of Reactive Astrocytes.
The thrombin receptor modulates astroglia-neuron trophic coupling and neural repair after spinal cord injury.
5α-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2.
Extracellular vesicles derived from CD73 modified human umbilical cord mesenchymal stem cells ameliorate inflammation after spinal cord injury.
Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche.
Critical Role of Astrocyte NAD(+) Glycohydrolase in Myelin Injury and Regeneration.
Matrine treatment induced an A2 astrocyte phenotype and protected the blood-brain barrier in CNS autoimmunity.
Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease.
Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy.
Differential and paradoxical roles of new-generation antidepressants in primary astrocytic inflammation.
The effects of A1/A2 astrocytes on oligodendrocyte linage cells against white matter injury under prolonged cerebral hypoperfusion.
Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection.
Blocking the Thrombin Receptor Promotes Repair of Demyelinated Lesions in the Adult Brain.
S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis.
Proteomic analysis of human periodontal ligament cells under hypoxia.
Down-regulation effects of IFN-α on p11, 5-htr1b and 5-HTR4 protein levels were affected by NH(4)CL or MG132 treatment in SH-sy5y cells.
Antibodies and methods for immunohistochemistry of extracellular matrix proteins.
S100A10, a novel biomarker in pancreatic ductal adenocarcinoma.
Probable involvement of p11 with interferon alpha induced depression.
Label-free quantification proteomics reveals novel calcium binding proteins in matrix vesicles isolated from mineralizing Saos-2 cells.
Feedback regulation of endothelial cell surface plasmin generation by PKC-dependent phosphorylation of annexin A2.
Wen H, Zi Y, Liu Z, Bai Y, Lin J, Wang H, Xu B, Wang J, Wang H
Cell death and differentiation 2026 Mar 3;
Cell death and differentiation 2026 Mar 3;
Astrocyte-Specific Nrf2 Expression Transforms Neurotoxic Reactive Astrocytes to Neuroprotective Phenotype in 3xTg-AD Mice.
Guo S, Wei F, Sun H, Jin H, Cheng W, Fu C, Wang H, Yin Y
Glia 2026 Jan;74(1):e70087
Glia 2026 Jan;74(1):e70087
MAFG Induces the Methylation of CRYAB to Promote the Activation of A1 Astrocyte After Spinal Cord Injury.
Li X, Zhu Z, Wang Y, Wan H, Wang Z, Qiao W
Immunity, inflammation and disease 2026 Jan;14(1):e70334
Immunity, inflammation and disease 2026 Jan;14(1):e70334
Mitochondrial Intercellular Transfer via Platelets After Physical Training Exerts Neuro-Glial Protection Against Cerebral Ischemia.
Inaba T, Miyamoto N, Hira K, Kijima C, Miyauchi Y, Xu HB, Kanazawa K, Ueno Y, Hattori N
MedComm 2026 Feb;7(2):e70590
MedComm 2026 Feb;7(2):e70590
S100A10 promotes glycolysis and malignant progression of CCA by activating the HK2/ERK signaling pathway.
Wang Y, Chen W, Liu W, Zhang X, Wang Y, Dai N
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2026 Feb 17;
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2026 Feb 17;
EGCG-loaded nanoparticles attenuate post-SAH white matter injury by targeting HO-1/S100A10 to suppress oxidative stress-induced reactive astrocytes.
Lang D, Zheng Y, Zhang J, Li Z, Niu M, Wang J, Wang X, Huang L, Xue J, Li L, Chen Y
Redox report : communications in free radical research 2026 Dec 31;31(1):2664955
Redox report : communications in free radical research 2026 Dec 31;31(1):2664955
Gut microbial ammonia as a mediator of PFOS neurotoxicity and its remediation by the flavonoid Icaritin.
Yi Y, Zhang W, Wei Y, Ran W, Liu D, Deng W, Duan S, Yao J, Wang L, Zhang Y, Gao J, Gong Q
Gut microbes 2026 Dec 31;18(1):2620125
Gut microbes 2026 Dec 31;18(1):2620125
Intermittent theta-burst stimulation promotes neurovascular unit remodeling after ischemic stroke in a mouse model.
Zhang J, Ding M, Luo L, Huang D, Li S, Chen S, Fan Y, Liu L, Xie H, Liu G, Yu K, Wu J, Xiao X, Wu Y
Neural regeneration research 2026 Aug 1;21(8):3598-3608
Neural regeneration research 2026 Aug 1;21(8):3598-3608
Shh-S100A10 axis curbs neuronal PANoptosis after ischemic stroke.
Wang L, Tang H, Wen J, Yang Q, Huang J, Zhao Y, Ren Y, Yang Q
Neural regeneration research 2026 Aug 1;21(8):3579-3587
Neural regeneration research 2026 Aug 1;21(8):3579-3587
YAP Regulates Microglial Anti-Inflammatory Responses and Alleviates Cognitive Impairment Through the IL-33/ST2 Pathway after Traumatic Brain Injury.
Zhao R, Gao SQ, Wang X, Li T, Gao CC, Han YL, Qiu JY, Miao SH, Sun Y, Zheng XB, Jin WX, Zhou ML
Journal of neurotrauma 2026 Apr;43(7-8):641-659
Journal of neurotrauma 2026 Apr;43(7-8):641-659
Targeting the HDAC4-NHE6-endosomal pH axis restores amyloid-β clearance and cognitive function in Alzheimer's disease mice.
Huang N, Hong R, Cui X, Cao L, Shi L, Chen B, Su Y, Xu X, Hua C, Ying T
Journal of nanobiotechnology 2026 Apr 3;24(1)
Journal of nanobiotechnology 2026 Apr 3;24(1)
Disruptions of p11 (S100A10) and HPA Axis Homeostasis Participate in the Major Depressive Disorder (MDD) Especially in Female Patients.
Yue Y, Zhang J, Li Y, Ma X, Chen G, Zhu Z, Chen S, Chen Y, You L, Tan L, Jiang W, Yuan Y
Neuropsychiatric disease and treatment 2025;21:2237-2249
Neuropsychiatric disease and treatment 2025;21:2237-2249
Astrocytic Ror2-induced imbalance in brain and gut homeostasis contributes to chronic post-thoracotomy pain.
Liu C, Shen L, Xu L, Zhu A, Huang Y
Frontiers in aging neuroscience 2025;17:1675725
Frontiers in aging neuroscience 2025;17:1675725
Golexanolone affords sustained microglia and astrocytes activation improvement in a rat model of Parkinson's disease.
Mincheva G, Pedrosa MA, Martínez-García Vázquez M, Vazquez L, Blackburn TP, Doverskog M, Llansola M, Felipo V
Frontiers in immunology 2025;16:1654664
Frontiers in immunology 2025;16:1654664
Targeting the miR-96-5p/Cathepsin B Pathway to Alleviate Neuron-Derived Neuroinflammation in Alzheimer's Disease.
Zheng K, Huang HZ, Liu D, Brazhe N, Chen J, Zhu LQ
MedComm 2025 Sep;6(9):e70368
MedComm 2025 Sep;6(9):e70368
Hypoxia-induced S100A10 promotes glioblastoma malignancy and chemoresistance by activating PI3K-AKT signaling pathway.
Yang Q, Xi Y, Huang X, An W, Sun C, Wang Q, Hua D, Luo W, Shi C, Pan H, Jiang Z, Wang B, Li X, Yu S, Zhou X
Functional & integrative genomics 2025 Sep 30;25(1):202
Functional & integrative genomics 2025 Sep 30;25(1):202
Echinacoside targets the HIF-1α/LDHA axis to modulate A1/A2 astrocyte differentiation and promote glial scar repair following ischemic stroke.
Liao Y, Yang L, Guo C, Hu J, Wen L, Ju B, Hou Q, Zhu H, Ding Y, Yang J, Zhao M
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120375
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120375
GRP78 alleviates secondary brain injury by regulating phenotype polarization in astrocytes via JAK2-STAT3 pathway after intracerebral hemorrhage.
Yang J, Duan C, Song Y, Zhu X, Shen J, Ji Q
International immunopharmacology 2025 Nov 14;165:115466
International immunopharmacology 2025 Nov 14;165:115466
Single-cell and spatial analyses reveal the effect of VSIG4(+)S100A10(+)TAMs on the immunosuppression of glioblastoma and anti-PD-1 immunotherapy.
Liu Z, Yang Y, Fang H, Cen B, Fan Y, Li J, Wang L, He S
International journal of biological macromolecules 2025 May;308(Pt 3):142415
International journal of biological macromolecules 2025 May;308(Pt 3):142415
SARM1 deletion inhibits astrogliosis and BBB damage through Jagged-1/Notch-1/NF-κB signaling to improve neurological function after ischemic stroke.
Fu YQ, Zheng Y, Li ZL, Huang XY, Wang XW, Cui MY, Zhang YQ, Gao BR, Zhang C, Fan XX, Jian Y, Chen BH
Neurobiology of disease 2025 May;208:106873
Neurobiology of disease 2025 May;208:106873
The roles of ROCK2/CBS-H(2)S pathway in the cerebral ischemia/reperfusion injury.
Yin X, Geng Z, Chen J, Deng G, Chen Z, Wen J
International journal of biological macromolecules 2025 Jun;313:144399
International journal of biological macromolecules 2025 Jun;313:144399
Effects of intermittent theta burst stimulation on the inflammatory response and cerebral blood flow in promoting neurovascular repair after ischemic stroke.
Zhang J, Li S, Huang D, Fu J, Chen S, Ren N, Yang P, Song D, Bai X, Xie H, Liu G, Yu K, Ng SSM, Wu J, Xiao X, Wu Y
Molecular brain 2025 Jun 9;18(1):48
Molecular brain 2025 Jun 9;18(1):48
DL-3-n-butylphthalide inhibits astrocyte activation in the cortical penumbra of ischemia-reperfusion model rats via AKT signaling.
Yu Y, Wang T, Li Q, Zhao H, Li B, Lei D, Dong F, Xiao Y, Wang S, Ji Y
Brain research bulletin 2025 Jun 1;225:111332
Brain research bulletin 2025 Jun 1;225:111332
The role of Genipin crosslinked extracellular matrix loaded bFGF in the repair of peripheral nerve injury.
Zhang Y, Zhuo G, Yu F, Xu X, Ruan Z, Hu X, Wang J, Zhu J
BMC biotechnology 2025 Jul 24;25(1):76
BMC biotechnology 2025 Jul 24;25(1):76
Cellular Landscape of Synovial Chondromatosis Synovium Revealed by Single-Cell RNA Sequencing.
Zhao H, Jiang F, Zhang P, Bi Y, Shen Y, Ma J, Gong J, Han K, Zhang L, Yu T, Xiao X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70799
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70799
Tracking astrocyte polarization in the retina in retinopathy of prematurity.
Feng X, Zhang L, Jiao K, Li Y, Wu M, Xie Y, Xiao L
Experimental eye research 2025 Jan;250:110170
Experimental eye research 2025 Jan;250:110170
Study on the Polarization of Astrocytes in the Optic Nerve Head of Rats Under High Intraocular Pressure: In Vitro.
Ma B, Ren J, Qian X
Bioengineering (Basel, Switzerland) 2025 Jan 23;12(2)
Bioengineering (Basel, Switzerland) 2025 Jan 23;12(2)
TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD.
Liu Z, Bai Y, Xu B, Wen H, Chen K, Lin J, Wang Y, Xu J, Wang H, Shi F, Wang J, Wang H
Journal of neuroinflammation 2025 Jan 22;22(1):14
Journal of neuroinflammation 2025 Jan 22;22(1):14
Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration.
Zhu J, Zhang Y, Sun Y, Yu F, Lu Y, Hu Q, Guo J, Zhang H, Chen T, Lian F, Wang J, Li X, Xiao J
Journal of nanobiotechnology 2025 Jan 2;23(1):1
Journal of nanobiotechnology 2025 Jan 2;23(1):1
VEGFD/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3/microglia IL-3Rα cross-talk and drives neuroinflammation in mouse ischemic stroke.
Wang S, Guo Y, Cao RQ, Zhu YM, Qiao SG, Du HP, Liu Y, Xu Y, Zhou XY, Sun L, Lu QX, Schoen I, Zhang HL
Acta pharmacologica Sinica 2025 Feb;46(2):292-307
Acta pharmacologica Sinica 2025 Feb;46(2):292-307
Intra-cisterna-magna bevacizumab injection (ICM-BI) reproduces pathological alterations of cerebral small vessel diseases.
Kang X, Su X, Li T, Wang S, Huang H, Liu Y, Li C, Deng X, Hu M, Lu T, Wei L, Cai W, Lu Z
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2025 Feb;45(2):244-258
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2025 Feb;45(2):244-258
VNS facilitates the neurological function recovery after ischemia/reperfusion injury by regulating the A1/A2 polarization of astrocytes through the NMU-NMUR2 pathway.
Jiang X, Yang W, Liu G, Tang H, Zhang R, Zhang L, Li C, Li S
Neurochemistry international 2025 Feb;183:105918
Neurochemistry international 2025 Feb;183:105918
The potential of taVNS in attenuating blood-brain barrier damage, promoting angiogenesis and improving impaired cognitive function in a rat model of vascular cognitive impairment and dementia by activating the Wnt7/β-catenin signaling pathway.
Sun R, Li H, Wang M, Yan L, Jiang J, Liu Q, Li S, Liang Y, Qian Y, Yu T
Autonomic neuroscience : basic & clinical 2025 Dec;262:103353
Autonomic neuroscience : basic & clinical 2025 Dec;262:103353
NEO1 modulates the A1 astrocyte polarization in subarachnoid hemorrhage through the cPLA2-MAVS signaling pathway.
Wu Y, Wei B, Jin L, Li L, Yang Z, Li C, Zhou J, Gong W, Feng X, Guo S, Cheng W, Li R, Liang S, Su S, Jin F, Zhang X, Liu Y, Duan C, Li X, Liu W
Journal of neuroinflammation 2025 Dec 4;23(1):6
Journal of neuroinflammation 2025 Dec 4;23(1):6
Scutellarin Modulates Astrocyte-Microglia-Neuron Crosstalk to Mitigate Neuroinflammation and Apoptosis in Cerebral Ischemia.
Chen H, Duan Z, Jia Q, Zhang X, Xu D, Zheng L, Qi Z, Yang Y, Yang L, Wu C
Molecular neurobiology 2025 Aug;62(8):10834-10855
Molecular neurobiology 2025 Aug;62(8):10834-10855
Astrocyte-conditional knockout of MOB2 inhibits the phenotypic conversion of reactive astrocytes from A1 to A2 following spinal cord injury in mice.
Tao X, Chen H, Zhu Z, Ren T, Zhen H, Sun X, Song Y, Xu X, Song Z, Liu J
International journal of biological macromolecules 2025 Apr;300:140289
International journal of biological macromolecules 2025 Apr;300:140289
Neuroimmune regulation of IFITM3 via γ-secretase in astrocytes during cerebral ischemia-reperfusion.
Ni X, Pan Y, Liu X, Zhu Y, Yao X, Mo Y, Dai Q, Wang J
Biochimica et biophysica acta. Molecular basis of disease 2025 Apr;1871(4):167733
Biochimica et biophysica acta. Molecular basis of disease 2025 Apr;1871(4):167733
Exosome-shuttled miR-5121 from A2 astrocytes promotes BSCB repair after traumatic SCI by activating autophagy in vascular endothelial cells.
Wang X, Zhou Z, Zhang Y, Liu J, Qin T, Zhou W, Li Q, Wu X, Xue K, Cao H, Su Y, Zhao S, Lu C, Jiang T, Yin G, Chen J
Journal of nanobiotechnology 2025 Apr 15;23(1):291
Journal of nanobiotechnology 2025 Apr 15;23(1):291
M1 Microglia-Derived Exosomes Promote A1 Astrocyte Activation and Aggravate Ischemic Injury via circSTRN3/miR-331-5p/MAVS/NF-κB Pathway.
Li Z, Xu P, Deng Y, Duan R, Peng Q, Wang S, Xu Z, Hong Y, Zhang Y
Journal of inflammation research 2024;17:9285-9305
Journal of inflammation research 2024;17:9285-9305
Effect of NLRP3 inflammasome induced astrocyte phenotype alteration in morphine tolerance.
Yuan Z, Lu B, Zhang M, Lu Y, Wang Z, Zhang W, Cheng H, Wu Z, Ji Q
Frontiers in pharmacology 2024;15:1434295
Frontiers in pharmacology 2024;15:1434295
Exploring the effects of moxibustion on cognitive function in rats with multiple cerebral infarctions from the perspective of glial vascular unit repairing.
Wang J, Du K, Liu C, Chen X, Ban W, Zhu G, Yang J
Frontiers in pharmacology 2024;15:1428907
Frontiers in pharmacology 2024;15:1428907
Montelukast improves disease outcome in SOD1(G93A) female mice by counteracting oligodendrocyte dysfunction and aberrant glial reactivity.
Raffaele S, Nguyen N, Milanese M, Mannella FC, Boccazzi M, Frumento G, Bonanno G, Abbracchio MP, Bonifacino T, Fumagalli M
British journal of pharmacology 2024 Sep;181(18):3303-3326
British journal of pharmacology 2024 Sep;181(18):3303-3326
Withaferin A protects against epilepsy by promoting LCN2-mediated astrocyte polarization to stopping neuronal ferroptosis.
Zhou Z, Zhang P, Ya D, Liu J, Xu Y, Zhang Y, Tang W, Zhou D, Liao R, Liu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155892
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155892
L-NRB alleviates amyotrophic lateral sclerosis by regulating P11-Htr4 signaling pathway.
Pan Y, Sun X, Tian Y, Yu M, Luo Y, Sun X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117588
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117588
Astrocytic purinergic signalling contributes to the development and maintenance of neuropathic pain via modulation of glutamate release.
Liu S, Cheng H, Cui L, Jin L, Li Y, Zhu C, Ji Q, Tang J
Journal of neurochemistry 2024 Nov;168(11):3727-3744
Journal of neurochemistry 2024 Nov;168(11):3727-3744
Targeting resident astrocytes attenuates neuropathic pain after spinal cord injury.
Zhao Q, Zhu Y, Ren Y, Zhao L, Zhao J, Yin S, Ni H, Zhu R, Cheng L, Xie N
eLife 2024 Nov 15;13
eLife 2024 Nov 15;13
Effect of Myelin Debris on the Phenotypic Transformation of Astrocytes after Spinal Cord Injury in Rats.
Lv J, Yu H, Shan F, Ye J, Li A, Jing J, Zheng M, Tian D
Neuroscience 2024 May 24;547:1-16
Neuroscience 2024 May 24;547:1-16
Fabry disease Schwann cells release p11 to induce sensory neuron hyperactivity.
Waltz TB, Chao D, Prodoehl EK, Enders JD, Ehlers VL, Dharanikota BS, Dahms NM, Isaeva E, Hogan QH, Pan B, Stucky CL
JCI insight 2024 Mar 7;9(8)
JCI insight 2024 Mar 7;9(8)
Transformation of A1/A2 Astrocytes Participates in Brain Ischemic Tolerance Induced by Cerebral Ischemic Preconditioning via Inhibiting NDRG2.
Liu XH, Zhang LY, Liu XY, Zhang JG, Hu YY, Zhao CG, Xian XH, Li WB, Zhang M
Neurochemical research 2024 Jul;49(7):1665-1676
Neurochemical research 2024 Jul;49(7):1665-1676
Astrocytic Extracellular Vesicles Regulated by Microglial Inflammatory Responses Improve Stroke Recovery.
Kijima C, Inaba T, Hira K, Miyamoto N, Yamashiro K, Urabe T, Hattori N, Ueno Y
Molecular neurobiology 2024 Feb;61(2):1002-1021
Molecular neurobiology 2024 Feb;61(2):1002-1021
Runx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice.
Lu L, Ye J, Yi D, Qi T, Luo T, Wu S, Yang L, Li L, Zhang H, Chen D
Molecular neurobiology 2024 Dec;61(12):10820-10829
Molecular neurobiology 2024 Dec;61(12):10820-10829
The Phenotype Changes of Astrocyte During Different Ischemia Conditions.
Meng F, Cui J, Wang P, Wang J, Sun J, Li L
Brain sciences 2024 Dec 14;14(12)
Brain sciences 2024 Dec 14;14(12)
A2 reactive astrocyte-derived exosomes alleviate cerebral ischemia-reperfusion injury by delivering miR-628.
Wang Y, Li H, Sun H, Xu C, Sun H, Wei W, Song J, Jia F, Zhong D, Li G
Journal of cellular and molecular medicine 2024 Aug;28(16):e70004
Journal of cellular and molecular medicine 2024 Aug;28(16):e70004
Sciatic nerve stimulation alleviates neuropathic pain and associated neuroinflammation in the dorsal root ganglia in a rodent model.
Wong CE, Liu W, Huang CC, Lee PH, Huang HW, Chang Y, Lo HT, Chen HF, Kuo LC, Lee JS
Journal of translational medicine 2024 Aug 14;22(1):770
Journal of translational medicine 2024 Aug 14;22(1):770
Synergistic effects of tetramethylpyrazine and astragaloside IV on spinal cord injury via alteration of astrocyte A1/A2 polarization through the Sirt1-NF-κB pathway.
Rao Y, Li J, Qiao R, Luo J, Liu Y
International immunopharmacology 2024 Apr 20;131:111686
International immunopharmacology 2024 Apr 20;131:111686
Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10.
Nakamura Y, Ito MA, Hoshino Y, Matsuoka I, Okada T, Okada Y, Nakanishi T
American journal of physiology. Cell physiology 2024 Apr 1;326(4):C1042-C1053
American journal of physiology. Cell physiology 2024 Apr 1;326(4):C1042-C1053
The origins and dynamic changes of C3- and S100A10-positive reactive astrocytes after spinal cord injury.
Zhao Q, Ren YL, Zhu YJ, Huang RQ, Zhu RR, Cheng LM, Xie N
Frontiers in cellular neuroscience 2023;17:1276506
Frontiers in cellular neuroscience 2023;17:1276506
Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress.
An JR, Liu JT, Gao XM, Wang QF, Sun GY, Su JN, Zhang C, Yu JX, Yang YF, Shi Y
Frontiers in cellular neuroscience 2023;17:1136070
Frontiers in cellular neuroscience 2023;17:1136070
miR-21-5p Inhibits the Proliferation, Migration, and Invasion of Glioma by Targeting S100A10.
Gao P, Wang H, Li H, Shu L, Han Z, Li S, Cheng H, Dai X
Journal of Cancer 2023;14(10):1781-1793
Journal of Cancer 2023;14(10):1781-1793
Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity.
Kong S, Chen TX, Jia XL, Cheng XL, Zeng ML, Liang JY, He XH, Yin J, Han S, Liu WH, Fan YT, Zhou T, Liu YM, Peng BW
Journal of neuroinflammation 2023 Oct 25;20(1):247
Journal of neuroinflammation 2023 Oct 25;20(1):247
Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut-brain axis.
Guo X, Li C, Zhang J, Sun M, Xu J, Xu C, Kuang H, Xu L
Nature aging 2023 Nov;3(11):1415-1429
Nature aging 2023 Nov;3(11):1415-1429
Roles of prokineticin 2 in electroconvulsive shock-induced memory impairment via regulation of phenotype polarization in astrocytes.
Chen L, Lv F, Min S, Yang Y, Liu D
Behavioural brain research 2023 May 28;446:114350
Behavioural brain research 2023 May 28;446:114350
Schwann cell release of p11 induces sensory neuron hyperactivity in Fabry disease.
Waltz TB, Chao D, Prodoehl EK, Ehlers VL, Dharanikota BS, Dahms NM, Isaeva E, Hogan QH, Pan B, Stucky CL
bioRxiv : the preprint server for biology 2023 May 28;
bioRxiv : the preprint server for biology 2023 May 28;
Bilirubin Induces A1-Like Reactivity of Astrocyte.
Li S, Huang H, Zhang Y, Li L, Hua Z
Neurochemical research 2023 Mar;48(3):804-815
Neurochemical research 2023 Mar;48(3):804-815
Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury.
Chang J, Qian Z, Wang B, Cao J, Zhang S, Jiang F, Kong R, Yu X, Cao X, Yang L, Chen H
Cell communication and signaling : CCS 2023 Feb 16;21(1):37
Cell communication and signaling : CCS 2023 Feb 16;21(1):37
Astrocytes and microglia-targeted Danshensu liposomes enhance the therapeutic effects on cerebral ischemia-reperfusion injury.
Bai M, Cui N, Liao Y, Guo C, Li L, Yin Y, Wen A, Wang J, Ye W, Ding Y
Journal of controlled release : official journal of the Controlled Release Society 2023 Dec;364:473-489
Journal of controlled release : official journal of the Controlled Release Society 2023 Dec;364:473-489
Pregabalin inhibits purinergic P2Y(2) receptor and TRPV4 to suppress astrocyte activation and to relieve neuropathic pain.
Song S, Wang Q, Qu Y, Gao W, Li D, Xu X, Yue S
European journal of pharmacology 2023 Dec 5;960:176140
European journal of pharmacology 2023 Dec 5;960:176140
The role of reactive astrocytes in neurotoxicity induced by ultrafine particulate matter.
Li B, Chang X, Liang X, Liu T, Shen Y, Zhang Q, Yang X, Lyu Y, Liu L, Guo J, Wu M, Gao Y, Yan X, Wang T, Zhang W, Qiu Y, Zheng J
The Science of the total environment 2023 Apr 1;867:161416
The Science of the total environment 2023 Apr 1;867:161416
NLRP3 inflammasome regulates astrocyte transformation in brain injury induced by chronic intermittent hypoxia.
She N, Shi Y, Feng Y, Ma L, Yuan Y, Zhang Y, Cao Z, Chen X, Zhao B, Liu H, Ren X
BMC neuroscience 2022 Nov 27;23(1):70
BMC neuroscience 2022 Nov 27;23(1):70
Homer1 promotes the conversion of A1 astrocytes to A2 astrocytes and improves the recovery of transgenic mice after intracerebral hemorrhage.
Fei X, Dou YN, Wang L, Wu X, Huan Y, Wu S, He X, Lv W, Wei J, Fei Z
Journal of neuroinflammation 2022 Mar 14;19(1):67
Journal of neuroinflammation 2022 Mar 14;19(1):67
Ror2 mediates chronic post-thoracotomy pain by inducing the transformation of A1/A2 reactive astrocytes in rats.
Liu C, Shen L, Xu L, Zhu A, Huang Y
Cellular signalling 2022 Jan;89:110183
Cellular signalling 2022 Jan;89:110183
S100A10 regulates tumor necrosis factor alpha-induced apoptosis in chondrocytes via the reactive oxygen species/nuclear factor-kappa B pathway.
Guo Y, Li R, Dang X
Biotechnology and applied biochemistry 2022 Dec;69(6):2284-2295
Biotechnology and applied biochemistry 2022 Dec;69(6):2284-2295
Cornuside Is a Potential Agent against Alzheimer's Disease via Orchestration of Reactive Astrocytes.
Shi JZ, Zheng XM, Zhou YF, Yun LY, Luo DM, Hao JJ, Liu PF, Zhang WK, Xu JK, Yan Y, Xie XM, He YY, Pang XB
Nutrients 2022 Aug 3;14(15)
Nutrients 2022 Aug 3;14(15)
The thrombin receptor modulates astroglia-neuron trophic coupling and neural repair after spinal cord injury.
Kim HN, Triplet EM, Radulovic M, Bouchal S, Kleppe LS, Simon WL, Yoon H, Scarisbrick IA
Glia 2021 Sep;69(9):2111-2132
Glia 2021 Sep;69(9):2111-2132
5α-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2.
Wei M, Zhou Y, Li C, Yang Y, Liu T, Liu Y, Wei Y, Liu N, Liu S, Wang Q, Cao S, Sun Y, Sheng P, Lu C, Yang C, Liu X, Yang G
Journal of medicinal chemistry 2021 Sep 9;64(17):12537-12547
Journal of medicinal chemistry 2021 Sep 9;64(17):12537-12547
Extracellular vesicles derived from CD73 modified human umbilical cord mesenchymal stem cells ameliorate inflammation after spinal cord injury.
Zhai X, Chen K, Yang H, Li B, Zhou T, Wang H, Zhou H, Chen S, Zhou X, Wei X, Bai Y, Li M
Journal of nanobiotechnology 2021 Sep 8;19(1):274
Journal of nanobiotechnology 2021 Sep 8;19(1):274
Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche.
He X, Smith SE, Chen S, Li H, Wu D, Meneses-Giles PI, Wang Y, Hembree M, Yi K, Zhao X, Guo F, Unruh JR, Maddera LE, Yu Z, Scott A, Perera A, Wang Y, Zhao C, Bae K, Box A, Haug JS, Tao F, Hu D, Hansen DM, Qian P, Saha S, Dixon D, Anant S, Zhang D, Lin EH, Sun W, Wiedemann LM, Li L
Cell reports 2021 Sep 7;36(10):109674
Cell reports 2021 Sep 7;36(10):109674
Critical Role of Astrocyte NAD(+) Glycohydrolase in Myelin Injury and Regeneration.
Langley MR, Choi CI, Peclat TR, Guo Y, Simon WL, Yoon H, Kleppe L, Lucchinetti CF, Chini CCS, Chini EN, Scarisbrick IA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Oct 13;41(41):8644-8667
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Oct 13;41(41):8644-8667
Matrine treatment induced an A2 astrocyte phenotype and protected the blood-brain barrier in CNS autoimmunity.
Jing Y, Ma R, Chu Y, Dou M, Wang M, Li X, Zhu L
Journal of chemical neuroanatomy 2021 Nov;117:102004
Journal of chemical neuroanatomy 2021 Nov;117:102004
Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease.
Qu H, Gong X, Liu X, Zhang R, Wang Y, Huang B, Zhang L, Zheng H, Zheng Y
Diabetes 2021 Jun;70(6):1372-1387
Diabetes 2021 Jun;70(6):1372-1387
Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy.
Shao L, Jiang GT, Yang XL, Zeng ML, Cheng JJ, Kong S, Dong X, Chen TX, Han S, Yin J, Liu WH, He XH, He C, Peng BW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21330
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21330
Differential and paradoxical roles of new-generation antidepressants in primary astrocytic inflammation.
He JH, Liu RP, Peng YM, Guo Q, Zhu LB, Lian YZ, Hu BL, Fan HH, Zhang X, Zhu JH
Journal of neuroinflammation 2021 Feb 18;18(1):47
Journal of neuroinflammation 2021 Feb 18;18(1):47
The effects of A1/A2 astrocytes on oligodendrocyte linage cells against white matter injury under prolonged cerebral hypoperfusion.
Miyamoto N, Magami S, Inaba T, Ueno Y, Hira K, Kijima C, Nakajima S, Yamashiro K, Urabe T, Hattori N
Glia 2020 Sep;68(9):1910-1924
Glia 2020 Sep;68(9):1910-1924
Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection.
Lou Y, Han M, Liu H, Niu Y, Liang Y, Guo J, Zhang W, Wang H
Cellular & molecular immunology 2020 Oct;17(10):1053-1062
Cellular & molecular immunology 2020 Oct;17(10):1053-1062
Blocking the Thrombin Receptor Promotes Repair of Demyelinated Lesions in the Adult Brain.
Yoon H, Choi CI, Triplet EM, Langley MR, Kleppe LS, Kim HN, Simon WL, Scarisbrick IA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Feb 12;40(7):1483-1500
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Feb 12;40(7):1483-1500
S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis.
Bharadwaj AG, Dahn ML, Liu RZ, Colp P, Thomas LN, Holloway RW, Marignani PA, Too CK, Barnes PJ, Godbout R, Marcato P, Waisman DM
Cancers 2020 Dec 7;12(12)
Cancers 2020 Dec 7;12(12)
Proteomic analysis of human periodontal ligament cells under hypoxia.
Li Q, Luo T, Lu W, Yi X, Zhao Z, Liu J
Proteome science 2019;17:3
Proteome science 2019;17:3
Down-regulation effects of IFN-α on p11, 5-htr1b and 5-HTR4 protein levels were affected by NH(4)CL or MG132 treatment in SH-sy5y cells.
Guo J, Ding H, Lv Z, Jiao J, Wang H, Ji Y
Journal of biosciences 2019 Sep;44(4)
Journal of biosciences 2019 Sep;44(4)
Antibodies and methods for immunohistochemistry of extracellular matrix proteins.
Rickelt S, Hynes RO
Matrix biology : journal of the International Society for Matrix Biology 2018 Oct;71-72:10-27
Matrix biology : journal of the International Society for Matrix Biology 2018 Oct;71-72:10-27
S100A10, a novel biomarker in pancreatic ductal adenocarcinoma.
Bydoun M, Sterea A, Liptay H, Uzans A, Huang WY, Rodrigues GJ, Weaver ICG, Gu H, Waisman DM
Molecular oncology 2018 Nov;12(11):1895-1916
Molecular oncology 2018 Nov;12(11):1895-1916
Probable involvement of p11 with interferon alpha induced depression.
Guo J, Zhang W, Zhang L, Ding H, Zhang J, Song C, Zhang Y, Xia N, Li M, Liang Y, Hu X, Luan H, Wang H
Scientific reports 2016 Jan 29;6:17029
Scientific reports 2016 Jan 29;6:17029
Label-free quantification proteomics reveals novel calcium binding proteins in matrix vesicles isolated from mineralizing Saos-2 cells.
Zhou X, Cui Y, Luan J, Zhou X, Zhang G, Zhang X, Han J
Bioscience trends 2013 Jun;7(3):144-51
Bioscience trends 2013 Jun;7(3):144-51
Feedback regulation of endothelial cell surface plasmin generation by PKC-dependent phosphorylation of annexin A2.
He KL, Sui G, Xiong H, Broekman MJ, Huang B, Marcus AJ, Hajjar KA
The Journal of biological chemistry 2011 Apr 29;286(17):15428-39
The Journal of biological chemistry 2011 Apr 29;286(17):15428-39
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse lung tissue were subjected to SDS PAGE followed by western blot with 11250-1-AP(S100A10 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using S100A10 antibody 11250-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 11250-1-AP(S100A10 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The S100A10 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human S100A10. This antibody recognizes human,mouse,rat antigen. The S100A10 antibody has been validated for the following applications: ELISA, WB, IHC, IF, FC analysis.
