Antibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10234-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10234-2-AP, RRID:AB_2240241
- Product name
- Transgelin 2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Transgelin 2 antibody (Cat. #10234-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease.
Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer.
TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer.
Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration.
MEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/ C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis.
Prognosis Analysis and Validation of m(6)A Signature and Tumor Immune Microenvironment in Glioma.
Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function.
Hypoxia-inducible transgelin 2 selects epithelial-to-mesenchymal transition and γ-radiation-resistant subtypes by focal adhesion kinase-associated insulin-like growth factor 1 receptor activation in non-small-cell lung cancer cells.
iTRAQ-coupled 2D LC/MS-MS analysis of CXCR7-transfected papillary thyroid carcinoma cells: A new insight into CXCR7 regulation of papillary thyroid carcinoma progression and identification of potential biomarkers.
TAGLN2, a novel regulator involved in Hepatitis B virus transcription and replication.
Functional significance of transgelin-2 in uterine cervical squamous cell carcinoma.
Comparative Tissue Proteomics of Microdissected Specimens Reveals Novel Candidate Biomarkers of Bladder Cancer.
Usefulness of material recovered from distal embolic protection devices after carotid angioplasty for proteomic studies.
MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma.
Identification of vascular breast tumor markers by laser capture microdissection and label-free LC-MS.
Comparative proteomic profiling in squamous cell carcinoma of the uterine cervix.
Post-translational modifications and protein-specific isoforms in endometriosis revealed by 2D DIGE.
Label-free detection of cancer biomarker candidates using surface plasmon resonance imaging.
Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma.
B-1 cells express transgelin 2: unexpected lymphocyte expression of a smooth muscle protein identified by proteomic analysis of peritoneal B-1 cells.
Zhang X, Tang L, Yang J, Meng L, Chen J, Zhou L, Wang J, Xiong M, Zhang Z
Nature communications 2023 Oct 21;14(1):6670
Nature communications 2023 Oct 21;14(1):6670
Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer.
Ji C, Zhao J, Chen H, Wang Z, Cai T, Tian C, Wang C, Liu D, Ye B, Fu M, Sun J, Li H, Wang X, Sun Y
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023 Dec;25(12):3405-3419
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023 Dec;25(12):3405-3419
TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
He Y, Zhang B, Han D, Du Y, Zhang X, Wang H, Yue Z, Shang P
Biochemical genetics 2023 Aug;61(4):1265-1281
Biochemical genetics 2023 Aug;61(4):1265-1281
Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer.
Liu X, Zhao S, Wang K, Zhou L, Jiang M, Gao Y, Yang R, Yan S, Zhang W, Lu B, Liu F, Zhao R, Liu W, Zhang Z, Liu K, Li X, Dong Z
Nature communications 2023 Aug 8;14(1):4779
Nature communications 2023 Aug 8;14(1):4779
Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration.
Ding R, Li G, Yao Y, Zhang L, Zhang X, Li J, Shen T, Gao Y, Wu T, Kong S, Huang M, Li Y
Journal of physiology and biochemistry 2022 Feb;78(1):99-108
Journal of physiology and biochemistry 2022 Feb;78(1):99-108
MEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/ C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis.
Yan Y, Zhu M, Ma J, He X, Yang X, Xu H, Jiang M, Zhang S, Duan Y, Han J, Chen Y
Bioengineered 2022 Apr;13(4):11214-11227
Bioengineered 2022 Apr;13(4):11214-11227
Prognosis Analysis and Validation of m(6)A Signature and Tumor Immune Microenvironment in Glioma.
Lin S, Xu H, Zhang A, Ni Y, Xu Y, Meng T, Wang M, Lou M
Frontiers in oncology 2020;10:541401
Frontiers in oncology 2020;10:541401
Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function.
Ortega FJ, Moreno-Navarrete JM, Mercader JM, Gómez-Serrano M, García-Santos E, Latorre J, Lluch A, Sabater M, Caballano-Infantes E, Guzmán R, Macías-González M, Buxo M, Gironés J, Vilallonga R, Naon D, Botas P, Delgado E, Corella D, Burcelin R, Frühbeck G, Ricart W, Simó R, Castrillon-Rodríguez I, Tinahones FJ, Bosch F, Vidal-Puig A, Malagón MM, Peral B, Zorzano A, Fernández-Real JM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Aug;33(8):9656-9671
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Aug;33(8):9656-9671
Hypoxia-inducible transgelin 2 selects epithelial-to-mesenchymal transition and γ-radiation-resistant subtypes by focal adhesion kinase-associated insulin-like growth factor 1 receptor activation in non-small-cell lung cancer cells.
Kim IG, Lee JH, Kim SY, Hwang HM, Kim TR, Cho EW
Cancer science 2018 Nov;109(11):3519-3531
Cancer science 2018 Nov;109(11):3519-3531
iTRAQ-coupled 2D LC/MS-MS analysis of CXCR7-transfected papillary thyroid carcinoma cells: A new insight into CXCR7 regulation of papillary thyroid carcinoma progression and identification of potential biomarkers.
Zhang H, Yang L, Liu Z, Liu C, Teng X, Zhang L, Yin B, Liu Z
Oncology letters 2017 Sep;14(3):3734-3740
Oncology letters 2017 Sep;14(3):3734-3740
TAGLN2, a novel regulator involved in Hepatitis B virus transcription and replication.
Yu Y, He Z, Cao Y, Tang H, Huang F
Biochemical and biophysical research communications 2016 Sep 2;477(4):1051-1058
Biochemical and biophysical research communications 2016 Sep 2;477(4):1051-1058
Functional significance of transgelin-2 in uterine cervical squamous cell carcinoma.
Yakabe K, Murakami A, Kajimura T, Nishimoto Y, Sueoka K, Sato S, Nawata S, Sugino N
The journal of obstetrics and gynaecology research 2016 May;42(5):566-72
The journal of obstetrics and gynaecology research 2016 May;42(5):566-72
Comparative Tissue Proteomics of Microdissected Specimens Reveals Novel Candidate Biomarkers of Bladder Cancer.
Chen CL, Chung T, Wu CC, Ng KF, Yu JS, Tsai CH, Chang YS, Liang Y, Tsui KH, Chen YT
Molecular & cellular proteomics : MCP 2015 Sep;14(9):2466-78
Molecular & cellular proteomics : MCP 2015 Sep;14(9):2466-78
Usefulness of material recovered from distal embolic protection devices after carotid angioplasty for proteomic studies.
Cristobo I, Brea D, Blanco M, Vázquez F, Rodríguez-Yáñez M, Vivancos J, Silva Y, de la Ossa NP, Pumar JM, Forteza J, Castillo J
Journal of vascular and interventional radiology : JVIR 2012 Jun;23(6):818-24
Journal of vascular and interventional radiology : JVIR 2012 Jun;23(6):818-24
MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma.
Elsner M, Rauser S, Maier S, Schöne C, Balluff B, Meding S, Jung G, Nipp M, Sarioglu H, Maccarrone G, Aichler M, Feuchtinger A, Langer R, Jütting U, Feith M, Küster B, Ueffing M, Zitzelsberger H, Höfler H, Walch A
Journal of proteomics 2012 Aug 3;75(15):4693-704
Journal of proteomics 2012 Aug 3;75(15):4693-704
Identification of vascular breast tumor markers by laser capture microdissection and label-free LC-MS.
Hill JJ, Tremblay TL, Pen A, Li J, Robotham AC, Lenferink AE, Wang E, O'Connor-McCourt M, Kelly JF
Journal of proteome research 2011 May 6;10(5):2479-93
Journal of proteome research 2011 May 6;10(5):2479-93
Comparative proteomic profiling in squamous cell carcinoma of the uterine cervix.
Fukushima C, Murakami A, Yoshitomi K, Sueoka K, Nawata S, Nakamura K, Sugino N
Proteomics. Clinical applications 2011 Apr;5(3-4):133-40
Proteomics. Clinical applications 2011 Apr;5(3-4):133-40
Post-translational modifications and protein-specific isoforms in endometriosis revealed by 2D DIGE.
Stephens AN, Hannan NJ, Rainczuk A, Meehan KL, Chen J, Nicholls PK, Rombauts LJ, Stanton PG, Robertson DM, Salamonsen LA
Journal of proteome research 2010 May 7;9(5):2438-49
Journal of proteome research 2010 May 7;9(5):2438-49
Label-free detection of cancer biomarker candidates using surface plasmon resonance imaging.
Ladd J, Taylor AD, Piliarik M, Homola J, Jiang S
Analytical and bioanalytical chemistry 2009 Feb;393(4):1157-63
Analytical and bioanalytical chemistry 2009 Feb;393(4):1157-63
Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma.
Rho JH, Roehrl MH, Wang JY
Journal of proteome research 2009 Dec;8(12):5610-8
Journal of proteome research 2009 Dec;8(12):5610-8
B-1 cells express transgelin 2: unexpected lymphocyte expression of a smooth muscle protein identified by proteomic analysis of peritoneal B-1 cells.
Francés R, Tumang JR, Kaku H, Gurdak SM, Rothstein TL
Molecular immunology 2006 May;43(13):2124-9
Molecular immunology 2006 May;43(13):2124-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human heart tissue were subjected to SDS PAGE followed by western blot with 10234-2-AP(TAGLN2 antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Transgelin 2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Transgelin 2. This antibody recognizes human, mouse antigen. The Transgelin 2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.