AGTO-G046S

antibody from Creative Biolabs

Targeting: ITGAE CD103, HUMINAE

Functional assay (Recommended by provider)

Antibody Data

Product number

AGTO-G046S

Provider

Creative Biolabs

Product name

Anti-Itgae immunotoxin M290 (IgG)-Sap

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-Itgae monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Itgae-expressing cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of organ allograft rejection and graft-versus-host disease.

Reactivity

Mouse

Host

Rat

Antibody clone number

M290