abx200481

antibody from Abbexa

Targeting: ITGAE CD103, HUMINAE

Flow cytometry (Recommended by provider)

Antibody Data

Product number

abx200481

Provider

Abbexa

Product name

Integrin Alpha-E / CD103 (ITGAE) Antibody (FITC)

Antibody type

Monoclonal

Description

CD103 is a type I transmembrane glycoprotein also known as αE integrin, integrin αIEL chain, and human mucosal lymphocyte antigen 1. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. Treg cells express high level of CD103. Hairy cell leukemia has also been shown to express CD103. The expression of CD103 on lymphocytes can be induced upon activation and TGF-b stimulation. In association with integrin b7, CD103 is expressed as an αE/b7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

Reactivity

Human, Simian

Host

Mouse

Conjugate

Green dye

Isotype

IgG

Vial size

100 tests

Storage

Aliquot and store in the dark at 2°C to 8°C. Avoid exposure to light.