350207

antibody from BioLegend

Targeting: ITGAE CD103, HUMINAE

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

350207

Provider

BioLegend

Proper citation

BioLegend Cat#350207, RRID:AB_10642027

Product name

Alexa Fluor® 488 anti-human CD103 (Integrin áE) [Ber-ACT8]

Antibody type

Monoclonal

Antigen

HTLV-1 induced human T cell line MAPS16

Description

CD103 is a type I transmembrane glycoprotein also known as αE integrin, integrin αIEL chain, and human mucosal lymphocyte antigen 1. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. Hairy cell leukemia has also been shown to express CD103. The expression of CD103 on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, 150 kD (C-terminal) chain and 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

Reactivity

Human, Simian

Host

Mouse

Conjugate

Green dye

Isotype

IgG

Vial size

25 tests

Storage

The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.