DCABH-9654

antibody from Creative Diagnostics

Targeting: FGFR1 BFGFR, CD331, CEK, FLG, FLT2, H2, H3, H4, H5, KAL2, N-SAM

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

DCABH-9654

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCABH-9654, RRID:AB_2482628

Product name

Rabbit Anti-B2M monoclonal antibody, clone TV46-16

Antibody type

Monoclonal

Description

Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an a heavy chain that contains three subdomains (Ï«1, Ï«2, Ï«3), and a non-covalent associating light chain, known as ÉÇ-2-Microglobulin. ÉÇ-2-Microglobulin associates with the a3 subdomain of the a heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The Ï«1 and Ï«2 domains of the a heavy chain form the peptide antigen-binding cleft. Mice that lack ÉÇ-2-Microglobulin protein show a normal distribution of T cells, yet have no mature CD4-8+ T cells and are defective in CD4-8+ T cell-mediated cytotoxicity. Interferon-ÎÛ can stimulate production of ÉÇ-2-Microglobulin transcripts. The human ÉÇ-2-Microglobulin gene maps to chromosome 15q21-q22.2 and encodes a 119 amino acid protein. Mutations in the ÉÇ-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

TV46-16

Vial size

100 _l

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.