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- Antigen structure
- References [18]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 55138-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55138-1-AP, RRID:AB_10804353
- Product name
- PRKG2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PRKG2 antibody (Cat. #55138-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Exploring the molecular mechanism of Shenling baizhu formula in the treatment of ulcerative colitis via the cGMP-PKG signaling pathway.
CIDEC impairs mitochondrial fitness and blocks protective autophagy via the inhibition of cGMP/PKG pathway to exert tumor-suppressive effects in breast cancer.
SMURF1 Affects Dental Implant Integration in Diabetes By Regulating PKG2 Expression.
EDNRB negatively regulates glycolysis to exhibit anti-tumor functions in prostate cancer by cGMP/PKG pathway.
Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAF(V600E)-induced growth arrest in melanocytes.
HDAC9 Deficiency Upregulates cGMP-dependent Kinase II to Mitigate Neuronal Apoptosis in Ischemic Stroke.
E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.
Microglial-derived nitric oxide regulates amygdala synaptic plasticity to drive chronic pain and depression induced by lumbar disc herniation.
EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway.
Inflammation-Related Gene ADH1A Regulates the Polarization of Macrophage M1 and Influences the Malignant Progression of Gastric Cancer.
Bifidobacterium pseudolongum-Derived Bile Acid from Dietary Carvacrol and Thymol Supplementation Attenuates Colitis via cGMP-PKG-mTORC1 Pathway.
Erianin Exerts Antineoplastic Effects on Esophageal Squamous Cell Carcinoma Cells by Activating the cGMP-PKG Signaling Pathway.
Sambucus williamsii Hance maintains bone homeostasis in hyperglycemia-induced osteopenia by reversing oxidative stress via cGMP/PKG signal transduction.
Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression.
High-Risk HPV16 E6 Activates the cGMP/PKG Pathway Through Glycosyltransferase ST6GAL1 in Cervical Cancer Cells.
The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway.
Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease.
Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine.
Chen J, Chen Y, Zheng H, Ding T, Xiang Y, Zhou X, Wang W, Li J, Li Z, Peng C, Fu Q, Li T, Fu Y
Journal of ethnopharmacology 2026 Jun 12;364:121498
Journal of ethnopharmacology 2026 Jun 12;364:121498
CIDEC impairs mitochondrial fitness and blocks protective autophagy via the inhibition of cGMP/PKG pathway to exert tumor-suppressive effects in breast cancer.
Jin X, Liu Y, Zheng X, He Y
Cellular oncology (Dordrecht, Netherlands) 2026 Apr 20;49(3)
Cellular oncology (Dordrecht, Netherlands) 2026 Apr 20;49(3)
SMURF1 Affects Dental Implant Integration in Diabetes By Regulating PKG2 Expression.
Wei XQ, Zhang SZ
Applied biochemistry and biotechnology 2025 Oct;197(10):6461-6479
Applied biochemistry and biotechnology 2025 Oct;197(10):6461-6479
EDNRB negatively regulates glycolysis to exhibit anti-tumor functions in prostate cancer by cGMP/PKG pathway.
Li X, Liu B, Wang S, Dong Q, Li J
Molecular and cellular endocrinology 2025 Mar 1;598:112459
Molecular and cellular endocrinology 2025 Mar 1;598:112459
Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAF(V600E)-induced growth arrest in melanocytes.
McGrail K, Granado-Martínez P, Orsenigo R, Caratù G, Nieto P, Heyn H, Ferrer B, Hernández-Losa J, Muñoz-Couselo E, García-Patos V, Recio JA
Oncogene 2025 Jun;44(21):1592-1608
Oncogene 2025 Jun;44(21):1592-1608
HDAC9 Deficiency Upregulates cGMP-dependent Kinase II to Mitigate Neuronal Apoptosis in Ischemic Stroke.
Lin H, Bei Y, Shen Z, Wei T, Ge Y, Yu L, Xu H, He W, Dai Y, Yao D, Dai H
Translational stroke research 2025 Jun;16(3):868-881
Translational stroke research 2025 Jun;16(3):868-881
E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.
Hao X, Hu Z, Li M, Zhang S, Tang M, Hao C, Qi S, Liang Y, Almeida MF, Smith K, Zuo C, Feng Y, Guo M, Ma D, Li S, Wang Z, Sun Y, Deng Z, Mao C, Xia Z, Jiang Y, Gao Y, Xu Y, Schisler JC, Shi C
The EMBO journal 2025 Feb;44(4):1249-1273
The EMBO journal 2025 Feb;44(4):1249-1273
Microglial-derived nitric oxide regulates amygdala synaptic plasticity to drive chronic pain and depression induced by lumbar disc herniation.
Huang Z, Sun J, Li H, Hu Z, Tan H, Fu Y, Gao L, Peng X, Lou H
Neuropharmacology 2025 Dec 1;280:110662
Neuropharmacology 2025 Dec 1;280:110662
EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway.
Li X, Liu B, Wang S, Dong Q, Li J
Open medicine (Warsaw, Poland) 2024;19(1):20230875
Open medicine (Warsaw, Poland) 2024;19(1):20230875
Inflammation-Related Gene ADH1A Regulates the Polarization of Macrophage M1 and Influences the Malignant Progression of Gastric Cancer.
Ma J, Shi Y, Lu Q, Huang D
Journal of inflammation research 2024;17:4647-4665
Journal of inflammation research 2024;17:4647-4665
Bifidobacterium pseudolongum-Derived Bile Acid from Dietary Carvacrol and Thymol Supplementation Attenuates Colitis via cGMP-PKG-mTORC1 Pathway.
Zhang K, Xu Y, Zheng Y, Zhang T, Wu Y, Yan Y, Lei Y, Cao X, Wang X, Yan F, Lei Z, Brugger D, Chen Y, Deng L, Yang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2406917
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2406917
Erianin Exerts Antineoplastic Effects on Esophageal Squamous Cell Carcinoma Cells by Activating the cGMP-PKG Signaling Pathway.
Deng X, Wu Q, Li D, Liu Y
Nutrition and cancer 2023;75(6):1473-1484
Nutrition and cancer 2023;75(6):1473-1484
Sambucus williamsii Hance maintains bone homeostasis in hyperglycemia-induced osteopenia by reversing oxidative stress via cGMP/PKG signal transduction.
Shen YW, Cheng YA, Li Y, Li Z, Yang BY, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154607
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154607
Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression.
Zhang H, Wang L, Cui J, Wang S, Han Y, Shao H, Wang C, Hu Y, Li X, Zhou Q, Guo J, Zhuang X, Sheng S, Zhang T, Zhou D, Chen J, Wang F, Gao Q, Jing Y, Chen X, Su J
Science advances 2023 Apr 5;9(14):eabo7868
Science advances 2023 Apr 5;9(14):eabo7868
High-Risk HPV16 E6 Activates the cGMP/PKG Pathway Through Glycosyltransferase ST6GAL1 in Cervical Cancer Cells.
Wang J, Liu G, Liu M, Cai Q, Yao C, Chen H, Song N, Yuan C, Tan D, Hu Y, Xiang Y, Xiang T
Frontiers in oncology 2021;11:716246
Frontiers in oncology 2021;11:716246
The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway.
Xiang T, Yuan C, Guo X, Wang H, Cai Q, Xiang Y, Luo W, Liu G
Cell death & disease 2021 Feb 4;12(2):150
Cell death & disease 2021 Feb 4;12(2):150
Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease.
Yin P, Liu Q, Pan Y, Yang W, Yang S, Wei W, Chen X, Hong Y, Bai D, Li XJ, Li S
EMBO reports 2020 Jun 4;21(6):e49783
EMBO reports 2020 Jun 4;21(6):e49783
Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine.
Ahsan MK, Tchernychev B, Kessler MM, Solinga RM, Arthur D, Linde CI, Silos-Santiago I, Hannig G, Ameen NA
Physiological reports 2017 Jun;5(11)
Physiological reports 2017 Jun;5(11)
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 55138-1-AP(PRKG2 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PRKG2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human PRKG2. This antibody recognizes human,mouse,rat antigen. The PRKG2 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon using 55138-1-AP(PRKG2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon using 55138-1-AP(PRKG2 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
