BS7791

antibody from Bioworld Technology, Inc
Targeting: FZR1 CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, KIAA1242
Provider product page for BS7791
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7791 - Provider product page
Provider
Bioworld Technology, Inc
Product name
FZR1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human FZR1.
Description
Fizzy-related protein, known as fzr, is a conserved eukaryotic gene that has been recently identified as a 7WD domain family member and is implicated in cell cycle regulation of Drosophila and yeast. Retroviral overexpression of fzr in B-lymphoma cells reduces tumor formation. Fzr overexpression increases B-lymphoma cell susceptibility to natural killer cell (NK) cytotoxicity. Fzr has been implicated in a new category of genes which suppress B-cell tumorigenesis. Current research suggests a novel role for fzr in the target cell interaction with NK cells. Fzr also negatively regulates the levels of cyclins A, B and B3. Loss of fzr causes progression through an extra division cycle in the epidermis and inhibition of endoreduplication in the salivary gland, in addition to failure of cyclin removal. Conversely, premature fzr overexpression downregulates mitotic cyclins, inhibits mitosis and transforms mitotic cycles into endoreduplication cycles.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
FZR1 protein structure - BS7791 shown in red.