BS7791
antibody from Bioworld Technology, Inc
Targeting: FZR1
CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, KIAA1242
Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS7791 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- FZR1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human FZR1.
- Description
- Fizzy-related protein, known as fzr, is a conserved eukaryotic gene that has been recently identified as a 7WD domain family member and is implicated in cell cycle regulation of Drosophila and yeast. Retroviral overexpression of fzr in B-lymphoma cells reduces tumor formation. Fzr overexpression increases B-lymphoma cell susceptibility to natural killer cell (NK) cytotoxicity. Fzr has been implicated in a new category of genes which suppress B-cell tumorigenesis. Current research suggests a novel role for fzr in the target cell interaction with NK cells. Fzr also negatively regulates the levels of cyclins A, B and B3. Loss of fzr causes progression through an extra division cycle in the epidermis and inhibition of endoreduplication in the salivary gland, in addition to failure of cyclin removal. Conversely, premature fzr overexpression downregulates mitotic cyclins, inhibits mitosis and transforms mitotic cycles into endoreduplication cycles.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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