AMM02081G
antibody from Leading Biology
Targeting: FZR1
CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, KIAA1242
Antibody data
- Antibody Data
- Antigen structure
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- Validations [0]
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- Product number
- AMM02081G - Provider product page
- Provider
- Leading Biology
- Product name
- FZR1 Antibody (clone 4C4)
- Antibody type
- Monoclonal
- Description
- Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
- Reactivity
- Human
- Host
- Mouse
- Antibody clone number
- 4C4
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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