CABT-BL1630

antibody from Creative Diagnostics

Targeting: GLIS2 NPHP7

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

CABT-BL1630

Provider

Creative Diagnostics

Product name

Anti-GLIS2 (aa 73-122) polyclonal antibody

Antibody type

Polyclonal

Description

This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this proteins C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.