Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-B11957 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Human anti-Human GZMA recombinant monoclonal antibody, clone SFB273
- Antibody type
- Monoclonal
- Description
- It recognozes granzyme A, a member of serine protease family expressed exclusively by cytotoxic T lymphocytes and natural killer (NK) cells. Granzyme A is a homodimeric protease and is one of the five granzymes expressed by humans. Also known as granule enzymes, granzymes comprise majority of the mass of cytolytic granules in cytotoxic T lymphocytes (CTLs) and NK cells. NK cells and \u03b3\u03b4 T cells express granzymes constitutively, whereas expression in T lymphocytes is stimulation dependent. Main function attributed to granzymes is to indue apoptotic death of infected and transformed cells. Granzymes other than granzyme B, exert relatively weaker apoptotic activity. Additional reported functions of granzyme A include, to facilitate the migration of T and NK cells and induction of cytokine secretion. Additional information: It displays negligible binding to Fc receptors.
- Reactivity
- Human
- Host
- Human
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- SFB273
- Vial size
- 100 _g in 100 _L
- Storage
- Store protected from light at 2ÿ8 °C. Do not freeze.
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