AGTO-G013E

antibody from Creative Biolabs

Targeting: CSPG4 CSPG4A, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2

Functional assay (Recommended by provider)

Antibody Data

Product number

AGTO-G013E

Provider

Creative Biolabs

Product name

Anti-CSPG4 immunotoxin (scFv)-PE

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-CSPG4 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating glioblastoma multiforme (GBM).

Reactivity

Human

Host

Mouse