AGTO-G014E

antibody from Creative Biolabs

Targeting: CSPG4 CSPG4A, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2

Functional assay (Recommended by provider)

Antibody Data

Product number

AGTO-G014E

Provider

Creative Biolabs

Product name

Anti-CSPG4 immunotoxin (IgG)-PE

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-CSPG4 monoclonal antibody to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating rhabdomyosarcoma.

Reactivity

Human

Host

Mouse