AGTO-G014S

antibody from Creative Biolabs

Targeting: CSPG4 CSPG4A, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2

No application information provided.

Antibody Data

Product number

AGTO-G014S

Provider

Creative Biolabs

Product name

Anti-CSPG4 immunotoxin (IgG)-Sap

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-CSPG4 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of rhabdomyosarcoma.

Reactivity

Human

Host

Mouse