14884-1-AP

antibody from Proteintech Group

Targeting: ALDOC

Provider product page for 14884-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [28]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 14884-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14884-1-AP, RRID:AB_2226691
Product name: Aldolase C antibody
Antibody type: Polyclonal
Description: KD/KO validated Aldolase C antibody (Cat. #14884-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ALDOC protein structure - 14884-1-AP shown in red.

Submitted references RPL35A drives aerobic glycolysis and tumorigenesis by facilitating MYC-mediated SKP2 transcription.

Yan L, Chen Y, Cao D, Hou M, Xue T, Zhang X
The Journal of biological chemistry 2026 Jan;302(1):110944

Hypoxia regulates glycolysis through the HIF-1α/BMAL1/ALDOC axis to reduce oxaliplatin sensitivity in colorectal cancer.

Ran J, Li F, Zhan L, Jin Y, Dong Q, Li X, Li X, Fei Q, Zhang J
Journal of Cancer 2025;16(8):2503-2515

Fructose-diphosphate aldolase C as a novel diagnostic biomarker for early-stage non-small cell lung cancer: a low-abundance proteomics study.

Bai C, Hao Q, Chen Y, Wang J, Xiao J, Kang DH, Ren L
Translational lung cancer research 2025 Jun 30;14(6):2239-2256

ALDOC and PGK1 coordinately induce glucose metabolism reprogramming and promote development of colorectal cancer.

Huang L, Tong Y, Li X, Wang W, Wang Z, Chen B, E J, Zhou R, Wang H, He J
Molecular medicine (Cambridge, Mass.) 2025 Jun 15;31(1):239

AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress.

Zhai X, Yang R, Chu Q, Guo Z, Hou P, Li X, Bai C, Lu Z, Qiao L, Fu Y, Niu J, Li B
Nature cell biology 2025 Jan;27(1):141-153

Plasma Proteomics Analysis of Early Biomarkers for Predicting Female Fecundability: A Nested Case-Control Study.

Huang L, Hong X, Zhang X, Li H, Wang X, Zhang Y, Yang H, Wang B
Journal of proteome research 2024 Sep 6;23(9):4102-4113

MAT1A activation of glycolysis to promote NSCLC progression depends on stabilizing CCND1.

Shen S, Liu R, Huang J, Sun Y, Tan Q, Luo Q, Liu R
Cell death & disease 2024 Oct 22;15(10):768

Increased NAD(+) levels protect female mouse reproductive system against zearalenone-impaired glycolysis, lipid metabolism, antioxidant capacity and inflammation.

Dai C, Hou M, Yang X, Wang Z, Sun C, Wu X, Wang S
Reproductive toxicology (Elmsford, N.Y.) 2024 Mar;124:108530

Dynamic changes of protein lactylation and their correlations with the glycolytic process during the postmortem acidification of broiler breast.

Wang Z, Xing T, Zhang L, Zhao L, Gao F
Poultry science 2024 Dec;103(12):104354

A pro-metastatic tRNA fragment drives aldolase A oligomerization to enhance aerobic glycolysis in lung adenocarcinoma.

Wang Q, Song X, Zhang Y, Liang S, Zhang M, Wang H, Feng Y, Li R, Ding H, Chen Y, Xia W, Dong G, Xu L, Mao Q, Jiang F
Cell reports 2024 Aug 27;43(8):114550

Aldolase A Promotes Colorectal Cancer Progression through Targeting COPS6 and Regulating MAPK Signaling Pathway.

Lu Y, Zhang Y, Wang X, Zhang H, Zhu Y, Zhang J, Sha H, Zou R, Gan Y, Sui Y, Wang J, Du T, Wu J, Feng J
Disease markers 2023;2023:1702125

The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity.

Sun X, He L, Liu H, Thorne RF, Zeng T, Liu L, Zhang B, He M, Huang Y, Li M, Gao E, Ma M, Cheng C, Meng F, Lang C, Li H, Xiong W, Pan S, Ren D, Dang B, Yang Y, Wu M, Liu L
Cell metabolism 2023 Sep 5;35(9):1563-1579.e8

Metabolic classification suggests the GLUT1/ALDOB/G6PD axis as a therapeutic target in chemotherapy-resistant pancreatic cancer.

Li Y, Tang S, Shi X, Lv J, Wu X, Zhang Y, Wang H, He J, Zhu Y, Ju Y, Zhang Y, Guo S, Yang W, Yin H, Chen L, Gao D, Jin G
Cell reports. Medicine 2023 Sep 19;4(9):101162

ALDOC promotes non-small cell lung cancer through affecting MYC-mediated UBE2N transcription and regulating Wnt/β-catenin pathway.

Shang B, Lu F, Jiang S, Xing M, Mao X, Yang G, Zhang H
Aging 2023 Sep 18;15(18):9614-9632

CircSOBP suppresses the progression of glioma by disrupting glycolysis and promoting the MDA5-mediated immune response.

Mu M, Niu W, Chu F, Dong Q, Hu S, Niu C
iScience 2023 Oct 20;26(10):107897

Cell type- and region-specific translatomes in an MPTP mouse model of Parkinson's disease.

Huang Q, Chen C, Chen W, Cai C, Xing H, Li J, Li M, Ma S
Neurobiology of disease 2023 May;180:106105

The function of lactate dehydrogenase A in retinal neurons: implications to retinal degenerative diseases.

Rajala A, Bhat MA, Teel K, Gopinadhan Nair GK, Purcell L, Rajala RVS
PNAS nexus 2023 Mar;2(3):pgad038

Effect of chronic heat stress on the carbonylation of glycolytic enzymes in breast muscle and its correlation with the growth performance of broilers.

Liu Y, Liu Z, Xing T, Li J, Zhang L, Zhao L, Gao F
Poultry science 2023 Dec;102(12):103103

Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro.

Li JQ, Jiang HJ, Su XY, Feng L, Zhan NZ, Li SS, Chen ZJ, Chang BH, Cheng PZ, Yang L, Pei GX
Stem cells international 2022;2022:4363632

O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine.

Kim K, Yoo HC, Kim BG, Kim S, Sung Y, Yoon I, Yu YC, Park SJ, Kim JH, Myung K, Hwang KY, Kim S, Han JM
Nature communications 2022 May 25;13(1):2904

GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase.

Liang RJ, Taylor S, Nahiyaan N, Song J, Murphy CJ, Dantas E, Cheng S, Hsu TW, Ramsamooj S, Grover R, Hwang SK, Ngo B, Cantley LC, Rhee KY, Goncalves MD
Cancer & metabolism 2021 Mar 24;9(1):12

Type I interferon decreases macrophage energy metabolism during mycobacterial infection.

Olson GS, Murray TA, Jahn AN, Mai D, Diercks AH, Gold ES, Aderem A
Cell reports 2021 Jun 1;35(9):109195

A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice.

Zhu M, Wang Q, Tian P, Cheng L, Sun Z, Hong Q, Lv P, Ji L, Liu Y, Tang QQ, Wen B
Biochimica et biophysica acta. Molecular basis of disease 2021 Jan 1;1867(1):165988

A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism.

Ho JJD, Balukoff NC, Theodoridis PR, Wang M, Krieger JR, Schatz JH, Lee S
Nature communications 2020 May 29;11(1):2677

Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes.

Hu J, Chen Z, Bao L, Zhou L, Hou Y, Liu L, Xiong M, Zhang Y, Wang B, Tao Z, Chen K
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Jul 8;28(7):1658-1672

C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis.

Allen SP, Hall B, Woof R, Francis L, Gatto N, Shaw AC, Myszczynska M, Hemingway J, Coldicott I, Willcock A, Job L, Hughes RM, Boschian C, Bayatti N, Heath PR, Bandmann O, Mortiboys H, Ferraiuolo L, Shaw PJ
Brain : a journal of neurology 2019 Dec 1;142(12):3771-3790

The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway.

Sun Z, Zhu M, Lv P, Cheng L, Wang Q, Tian P, Yan Z, Wen B
Stem cell reports 2018 Sep 11;11(3):741-755

Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain.

Zhao W, Jiang B, Hu H, Zhang S, Lv S, Yuan J, Qian Y, Zou Y, Li X, Jiang H, Liu F, Shao C, Gong Y
Human molecular genetics 2015 Aug 15;24(16):4686-97

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with 14884-1-AP(ALDOC antibody) at dilution of 1:800
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using ALDOC antibody 14884-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line