AGTO-G034F

antibody from Creative Biolabs

Targeting: GPA33 A33

No application information provided.

Antibody Data

Product number

AGTO-G034F

Provider

Creative Biolabs

Product name

Anti-GPA33 immunotoxin (scFv)-¦Á-sar

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-GPA33 scFv to ¦Á-sarcin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to GPA33 tumor antigen expressing cells. Once bind, alpha-Sarcin enters into the cells by receptor-mediated endocytosis and interacts with a single bond in the targeted ribosome and breaks it, causing the ribosome to be inactivated. It was designed for treatment of colon cancer.

Reactivity

Human

Host

Mouse