Antibody data
- Antibody Data
- Antigen structure
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- Product number
- AGTO-G034F - Provider product page
- Provider
- Creative Biolabs
- Product name
- Anti-GPA33 immunotoxin (scFv)-¦Á-sar
- Antibody type
- Monoclonal
- Description
- This immunotoxin was achieved by conjugating/fusing the Anti-GPA33 scFv to ¦Á-sarcin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to GPA33 tumor antigen expressing cells. Once bind, alpha-Sarcin enters into the cells by receptor-mediated endocytosis and interacts with a single bond in the targeted ribosome and breaks it, causing the ribosome to be inactivated. It was designed for treatment of colon cancer.
- Reactivity
- Human
- Host
- Mouse
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