Antibody data

Product number
17-2018-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD201 (EPCR) Monoclonal Antibody (RCR-227), APC, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: The monoclonal antibody RCR-227 reacts with human CD201, which is also known as the endothelial protein C receptor (EPCR), a 46-kDa transmembrane protein related to class I MHC. CD201 was originally identified on vascular endothelium cells, predominantly larger blood vessels. It is also expressed on monocytes, lymphocytes, hematopoietic stem cells, neutrophils, and eosinophils. CD201 serves as a binding site for protein C, activated protein C (APC), and factor VII/VIIa. A soluble form has also been identified in the plasma. CD201 plays a role in controlling coagulation as disruption of its gene in mice caused placental thrombosis and early embryonic death. This cell surface molecule is also involved in the anti-inflammatory response. APC binding to CD201 enables PAR-1 activation that confers cytoprotective effects. In monocytes, APC binding decreases secretion of proinflammatory cytokines, chemokines, and growth factors. Finally, CD201 has been shown to inhibit lymphocyte migration.
Antibody clone number
RCR-227
Concentration
5 µL/Test
PROCR protein structure - 17-2018-42 shown in red.