12737-1-AP

antibody from Proteintech Group

Targeting: ZFP36 G0S24, NUP475, RNF162A, TIS11, TTP

Provider product page for 12737-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [35]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

Submit

Product number: 12737-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12737-1-AP, RRID:AB_10598485
Product name: ZFP36 antibody
Antibody type: Polyclonal
Description: ZFP36 antibody (Cat. #12737-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ZFP36 protein structure - 12737-1-AP shown in red.

Submitted references Single-cell sequencing reveals reversible glial remodeling in the visual cortex during visual deprivation and recovery.

Gong X, Feng J, Xu Z, Xie Y, Han Y, Li J, Tang G, Liu Y, Dong X, Li S, Zhang J, Wang J, Liu R, Song J, Bi H
Frontiers in immunology 2026;17:1730619

Type II Alveolar Epithelial Cells Promote Sepsis-Induced Immunosuppression in Alveolar Macrophages via Exosomal lncRNA Rmrp Release.

Liu C, Xuan W, Cao S, Jia H, Wu Q, Tan X, Wang Q, Li X, Ding L, Xiong Y, Zhao M, Zheng L, Xi Y, Tan J, Li R, Zhang X, Liu W, Wu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e00376

Tet2 deficiency-induced expansion of monocyte-derived macrophages promotes liver fibrosis.

Feng J, Wu B, Li Y, Sun P, Liu Q, Xiao Q, Cai JB, Zheng Y, Chen H, Xu Y, Liu Y, Shi GM, Tan L, Shi YG
The Journal of experimental medicine 2026 Feb 2;223(2)

Characterization of NLRP3 Inflammasome-Associated Hub Genes in the Progression of Diabetic Nephropathy.

Zhao S, Li Y, Li W, Dong L, Lian R, Luo Q, Lian X, Li J, He F
Immunity, inflammation and disease 2026 Apr;14(4):e70424

Machine Learning-Based Identification and Experimental Validation of Hub Ferroptosis-Related Cuproptosis Genes in Lupus Nephritis.

Zhang S, Hu W, Zhang Y, Huang C, He Z, Xu J, Lin S, Yang B, Chen X
Journal of inflammation research 2025;18:11335-11353

Identification of conserved gene expression changes across common glomerular diseases by spatial transcriptomics.

Cho JM, Kang M, Park S, Oh J, Ku H, Shin HY, Koh JH, Cho S, Kim Y, Lee S, Kim YC, Han SS, Joo KW, Kim YS, Yang SH, Moon KC, Lee H, Kim HJ, Kim DK, KORNERSTONE investigators
Journal of nephrology 2025 Sep;38(7):1819-1829

Downregulation of ZFP36L1 contributes to methotrexate resistance in osteosarcoma through enhanced NHEJ DNA repair mechanisms.

Zhuang J, Ma M, Yang B, Liu Y, Mi R, Yang W, Lu Y, Yu H, Wu W, Song Y, Wang P, Li H
Cell death & disease 2025 Nov 24;16(1):852

Deletion of smooth muscle ZFP36 promotes neointimal hyperplasia in mice.

Wang L, He LF, Xiong X, Wu ZN, Tian M, Cao GQ, Lu HX, Ji XP, Zhang YL, Kovarik P, Zhang W, Liu Y
Acta pharmacologica Sinica 2025 May;46(5):1317-1328

Targeting Zfp36 to combat cardiac hypertrophy: Insights into ferroptosis pathways.

Zhang M, Guan X, Dong Z, Yang C, Xiong C, Cheng W, Shang A, Liu Y, Guo X, Zhang B, Zhang B, Jin S, Qi W, Alexandrovna BT, Jiang Y, Du Z, Xu C
Clinical and translational medicine 2025 Mar;15(3):e70247

Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness.

Cui B, Luo H, He B, Liu X, Lv D, Zhang X, Su K, Zheng S, Lu J, Wang C, Yang Y, Zhao Z, Liu X, Wang X, Zhao Y, Nie X, Jiang Y, Zhang Z, Liu C, Chen X, Cai A, Lv Z, Liu Z, An F, Zhang Y, Yan Q, Kelley KW, Xu G, Xu L, Liu Q, Peng F
Signal transduction and targeted therapy 2025 Mar 5;10(1):79

ILF3 promotes colorectal cancer cell resistance to ferroptosis by enhancing cysteine uptake and GSH synthesis via stabilizing SLC3A2 mRNA.

Wang S, Zhu L, Wang Y, Han Y, Wang Q, Yang W, Zhao L, Zhang Y, Pei D, Huang W, Jin A, Lin Z, Piao J
Cell death & disease 2025 Jul 23;16(1):549

Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses.

Zhao Q, Wang Q, Yao Q, Yang Z, Li W, Cheng X, Wen Y, Chen R, Xu J, Wang X, Qin D, Zhu S, He L, Li N, Wu Y, Yu Y, Cao X, Wang P
Cell research 2025 Feb;35(2):97-116

Glabridin inhibits proliferation and migration in hepatocellular carcinoma by regulating multi-targets.

Wang F, Yuan C, Lu Y, Wu M, Wu H, Liu Y, Yang Y
Journal of ethnopharmacology 2025 Feb 10;338(Pt 1):119022

ZFP36 reverses chemoresistance by disrupting lipid droplets accumulation in non-small cell lung cancer.

Wang Z, Hou P, Wu Y, Dai J, Zhao P, Cheng X, Hu Z, Zhang L, Hua J
Cellular signalling 2025 Dec;136:112119

The ZFP36-FTO axis is a key regulator of macrophage activation and a druggable therapeutic target of sepsis.

Sarkar R, Wang L, Du J, Blackshear PJ, Li YC
iScience 2025 Dec 19;28(12):114060

Single-cell RNA transcriptome analysis reveals regulatory programs of RNA binding proteins in diabetic foot ulcers.

Hu Q, Liu L, Pei J, Yan Y, Chen Y, Tang S
Scientific reports 2025 Aug 23;15(1):31059

LncRNA AA465934 Improves Podocyte Injury by Promoting Tristetraprolin-Mediated HMGB1 DownRegulation in Diabetic Nephropathy.

Yang N, Zhang Y, Ren P, Zhao L, Zheng D, Fu L, Jin J
Molecular and cellular biology 2024;44(3):87-102

Identification and Validation of Glomeruli Cellular Senescence-Related Genes in Diabetic Nephropathy by Multiomics.

Tang C, Yang C, Wang P, Li L, Lin Y, Yi Q, Tang F, Liu L, Zhou W, Liu D, Zhang L, Yuan X
Advanced biology 2024 Feb;8(2):e2300453

Synovium is a sensitive tissue for mapping the negative effects of systemic iron overload in osteoarthritis: identification and validation of two potential targets.

Jin Z, Zhang H, Bai L, Yue L, Zhang W, Liang J, Chang B, Yang Y, Hu Z, Chen L, Guo C
Journal of translational medicine 2023 Sep 23;21(1):661

Cancer-associated fibroblasts suppressed ferroptosis in glioblastoma via upregulating lncRNA DLEU1.

Zhao J, Yang S, Lv C, Liu Y
American journal of physiology. Cell physiology 2023 May 1;324(5):C1039-C1052

Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA.

Zhang W, Pan X, Xu Y, Guo H, Zheng M, Chen X, Wu H, Luan F, He Q, Ding L, Yang B
Acta pharmaceutica Sinica. B 2023 Jun;13(6):2585-2600

Targeting lncRNA DDIT4-AS1 Sensitizes Triple Negative Breast Cancer to Chemotherapy via Suppressing of Autophagy.

Jiang T, Zhu J, Jiang S, Chen Z, Xu P, Gong R, Zhong C, Cheng Y, Sun X, Yi W, Yang J, Zhou W, Cheng Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(17):e2207257

Type I IFN stimulates lymph node stromal cells from adult and old mice during a West Nile virus infection.

Bennett AK, Richner M, Mun MD, Richner JM
bioRxiv : the preprint server for biology 2023 Jan 5;

Type I IFN stimulates lymph node stromal cells from adult and old mice during a West Nile virus infection.

Bennett AK, Richner M, Mun MD, Richner JM
Aging cell 2023 Apr;22(4):e13796

Intestinal Flora-Derived Kynurenic Acid Protects Against Intestinal Damage Caused by Candida albicans Infection via Activation of Aryl Hydrocarbon Receptor.

Wang Z, Yin L, Qi Y, Zhang J, Zhu H, Tang J
Frontiers in microbiology 2022;13:934786

FTH1- and SAT1-Induced Astrocytic Ferroptosis Is Involved in Alzheimer's Disease: Evidence from Single-Cell Transcriptomic Analysis.

Dang Y, He Q, Yang S, Sun H, Liu Y, Li W, Tang Y, Zheng Y, Wu T
Pharmaceuticals (Basel, Switzerland) 2022 Sep 22;15(10)

Identification of ISG15 and ZFP36 as novel hypoxia- and immune-related gene signatures contributing to a new perspective for the treatment of prostate cancer by bioinformatics and experimental verification.

Lyu F, Li Y, Yan Z, He Q, Cheng L, Zhang P, Liu B, Liu C, Song Y, Xing Y
Journal of translational medicine 2022 May 10;20(1):202

Comprehensive Analysis of the Tumor Microenvironment and Ferroptosis-Related Genes Predict Prognosis with Ovarian Cancer.

Li XX, Xiong L, Wen Y, Zhang ZJ
Frontiers in genetics 2021;12:774400

CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development.

Dai XX, Jiang ZY, Wu YW, Sha QQ, Liu Y, Ding JY, Xi WD, Li J, Fan HY
Cell reports 2021 Nov 16;37(7):110007

Multivalent Proteins Rapidly and Reversibly Phase-Separate upon Osmotic Cell Volume Change.

Jalihal AP, Pitchiaya S, Xiao L, Bawa P, Jiang X, Bedi K, Parolia A, Cieslik M, Ljungman M, Chinnaiyan AM, Walter NG
Molecular cell 2020 Sep 17;79(6):978-990.e5

Tristetraprolin destabilizes NOX2 mRNA and protects dopaminergic neurons from oxidative damage in Parkinson's disease.

Sun X, Zhang H, Xie L, Qian C, Ye Y, Mao H, Wang B, Zhang H, Zhang Y, He X, Zhang S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Nov;34(11):15047-15061

N(6)-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.

Du J, Liao W, Liu W, Deb DK, He L, Hsu PJ, Nguyen T, Zhang L, Bissonnette M, He C, Li YC
Developmental cell 2020 Dec 21;55(6):737-753.e7

The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2.

Wang Y, Chen F, Yang Z, Zhao M, Zhang S, Gao Y, Feng J, Yang G, Zhang W, Ye L, Zhang X
Scientific reports 2017 May 18;7(1):2070

Inhibition of COX2 enhances the chemosensitivity of dichloroacetate in cervical cancer cells.

Li B, Li X, Xiong H, Zhou P, Ni Z, Yang T, Zhang Y, Zeng Y, He J, Yang F, Zhang N, Wang Y, Zheng Y, He F
Oncotarget 2017 Aug 1;8(31):51748-51757

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase.

Tan FE, Elowitz MB
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 29;111(17):E1740-8

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse lung tissue were subjected to SDS PAGE followed by western blot with 12737-1-AP(ZFP36 antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ZFP36 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ZFP36. This antibody recognizes human,mouse,rat antigen. The ZFP36 antibody has been validated for the following applications: ELISA, WB, IF, IHC analysis.
Appendix: 12737-1-AP.pdf

: Show more