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Immunoprecipitation
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 312907 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#312907, RRID:AB_2072708
- Product name
- LEAF™ purified anti-human CD180 (RP105) [MHR73-11]
- Antibody type
- Monoclonal
- Antigen
- Human RP105 complexed with mouse MD-1
- Description
- CD180, also known as RP105, is a 105 kD member of the toll-like receptor (TLR) family and is expressed on most B cells, monocytes/macrophages and dendritic cells. The TLR family's structural characteristics are critically involved in protein-protein signaling interactions leading to the activation of the innate immune system. Additionally, MD-1, a secretory protein, associates with CD180 (RP105) at the cell surface and this complex, in conjunction with TLR4, recognizes bacterial LPS. The human CD180 (RP105) gene maps to 5q12. The MHR73-11 antibody is able to activate B cells and to protect against irradiation- or dexamethasone-induced apoptosis.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 1 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C. This LEAF™ solution contains no preservative; handle under aseptic conditions.
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- BioLegend (provider)
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- Experimental details
- Human peripheral blood lymphocytes stained with LEAF™ purified MHR73-11, followed by anti-mouse IgG FITC
- Conjugate
- Unconjugated
