BS1973

antibody from Bioworld Technology, Inc
Targeting: ERCC5 ERCM2, XPGC
Provider product page for BS1973
Western blot
Immunohistochemistry

Antibody data

Product number
BS1973 - Provider product page
Provider
Bioworld Technology, Inc
Product name
ERCC5/XPG (E160) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 130-180 of Human ERCC5/XPG.
Description
Seven complementation groups (A-G) of xeroderma pigmentosum have been described. The xeroderma pigmentosum group A protein, XPA, is a zinc metalloprotein which preferentially binds to DNA damaged by ultraviolet (UV) radiation and chemical carcinogens. XPA is a DNA repair enzyme that has been shown to be required for the incision step of nucleotide excision repair. XPG (also designated ERCC5) is an endonuclease that makes the 3£ª incision in DNA nucleotide excision repair. Mammalian XPG is similar in sequence to yeast RAD2. Conserved residues in the catalytic center of XPG are important for nuclease activity and function in nucleotide excision repair.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ERCC5 protein structure - BS1973 shown in red.