25245-1-AP

antibody from Proteintech Group

Targeting: SLC10A2 ASBT, ISBT

Provider product page for 25245-1-AP

Western blot

ELISA

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [24]
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Validations
Immunoprecipitation [1]

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Product number: 25245-1-AP - Provider product page
Provider: Proteintech Group
Product name: ASBT antibody
Antibody type: Polyclonal
Description: ASBT antibody (Cat. #25245-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SLC10A2 protein structure - 25245-1-AP shown in red.

Submitted references The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP-1 Signaling in Colorectal Cancer.

Hu Z, Xun J, Liu B, Jiang X, Han Y, Yang H, Gao Q, Gao R, Zhang A, Wu X, Zhang D, Li D, Li T, Yang S, Wang X, Yu X, Zhang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(9):e14086

Identification of Paraptosis-Related Renal Cell Carcinoma Subtypes, Construction of a Prognostic Signature, and Determination of Tumor Microenvironment Landscape Using Bioinformatic Analysis and Experimental Verification.

Qin M, Chen M, Gan Y, Feng X, Huang P, Meng F, Yang Y
Current issues in molecular biology 2026 Feb 23;48(2)

Functional Liposomes Improve the Oral Absorption of Lurasidone Hydrochloride by Overcoming Multiple Absorption Barriers and Eliminating Food Effect.

Song T, Wang W, Wu Y, Liu C, Yuan L, Sun Z, Zhang J, Sun Y
International journal of nanomedicine 2025;20:4883-4901

Veillonella intestinal colonization promotes C. difficile infection in Crohn's disease.

Yang Z, Wang J, Chen Y, Chen T, Shen Z, Wang Y, Jian Y, Xiang G, Ma X, Zhao N, Song Y, Shi B, Qin J, Liu Q, Cao Z, Otto M, Li M
Cell host & microbe 2025 Sep 10;33(9):1518-1534.e10

Capsaicin ameliorates cholestasis through modulation of the FXR-SHP and FXR-FGF15 gut-liver axis in mice.

Du H, Luo Y, Zhou N, Wang T, Wang R, Wang Y, Lv C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157130

Cortex Dictamni induces cholestatic liver injury via the bile acid-gut-liver axis mediated by FXR signaling pathway in rats.

Xu X, Lu F, Yu D, Wang Y, Chen P, Hu W, Jia S, Wo J, Liu S
Journal of ethnopharmacology 2025 Jul 24;351:120019

Salvianolic acid B attenuates hypercholesterolemia via modulating the gut microbiota and bile acid metabolism.

Meng X, Chen Y, Zhao B, Liu Q, Zhao L, Zheng X, Feng W
European journal of pharmacology 2025 Jul 15;999:177701

Engineering micelles with hydrophilic-lipophilic balance to overcome intestinal barrier for oral therapeutic application.

Liu K, Zhao P, Chen Y, Zhang Y, Jin J, Wan T
Materials today. Bio 2025 Dec;35:102369

Determination of Site-Specific Phosphorylation Occupancy Using Targeted Mass Spectrometry Reveals the Regulation of Human Apical Bile Acid Transporter, ASBT.

Nguyen TT, Kane MA, Swaan PW
ACS omega 2024 Sep 17;9(37):38477-38489

Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice.

Jiang X, Liu K, Luo P, Li Z, Xiao F, Jiang H, Wu S, Tang M, Yuan F, Li X, Shu Y, Peng B, Chen S, Ni S, Guo F
Nature communications 2024 Sep 11;15(1):7948

The Effect of Coenzyme Q10 Supplementation on Bile Acid Metabolism: Insights from Network Pharmacology, Molecular Docking, and Experimental Validation.

Jin M, Zou T, Huang H, Chen M, Zou H, Chen B, Lai C, Li H, Zhang P
Molecular nutrition & food research 2024 May;68(9):e2400147

Postbiotics Prepared Using Lactobacillus reuteri Ameliorates Ethanol-Induced Liver Injury by Regulating the FXR/SHP/SREBP-1c Axis.

Liu C, Cai T, Cheng Y, Bai J, Li M, Gu B, Huang M, Fu W
Molecular nutrition & food research 2024 Jul;68(14):e2300927

Melatonin alleviates necrotizing enterocolitis by reducing bile acid levels through the SIRT1/FXR signalling axis.

Lai J, Li F, Li H, Huang R, Ma F, Gu X, Cai Y, Huang D, Li S, Xiao S, Hao H
International immunopharmacology 2024 Feb 15;128:111360

Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling.

Xiao J, Dong LW, Liu S, Meng FH, Xie C, Lu XY, Zhang WJ, Luo J, Song BL
Nature communications 2023 Oct 13;14(1):6469

L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism.

Xu W, Kong Y, Zhang T, Gong Z, Xiao W
Journal of the science of food and agriculture 2023 Feb;103(3):1283-1293

Apple polyphenol extract modulates bile acid metabolism and gut microbiota by regulating the circadian rhythms in daytime-restricted high fat diet feeding C57BL/6 male mice.

Cui Y, Yin Y, Li S, Wu Z, Xie Y, Qian Q, Yang H, Li X
Food & function 2022 Mar 7;13(5):2805-2822

L-Arabinose improves hypercholesterolemia via regulating bile acid metabolism in high-fat-high-sucrose diet-fed mice.

Wang Y, Zhao J, Li Q, Liu J, Sun Y, Zhang K, Fan M, Qian H, Li Y, Wang L
Nutrition & metabolism 2022 Apr 15;19(1):30

S-acylation status of bile acid transporter hASBT regulates its function, metabolic stability, membrane expression, and phosphorylation state.

Ayewoh EN, Czuba LC, Nguyen TT, Swaan PW
Biochimica et biophysica acta. Biomembranes 2021 Feb 1;1863(2):183510

Novel Metabolic Regulation of Bile Acid Responses to Low Cholesterol in Whole-Grain-Diet-Fed Mice.

Liu J, Wang Y, Xue L, Nie C, Sun J, Fan M, Qian H, Wang L, Li Y
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8440-8447

Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids.

Liu J, Li Y, Sun C, Liu S, Yan Y, Pan H, Fan M, Xue L, Nie C, Zhang H, Qian H, Ying H, Wang L
Pharmacological research 2020 Feb;152:104631

Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis.

Pan Q, Zhang X, Zhang L, Cheng Y, Zhao N, Li F, Zhou X, Chen S, Li J, Xu S, Huang D, Chen Y, Li L, Wang H, Chen W, Cai SY, Boyer JL, Chai J
Gastroenterology 2018 Nov;155(5):1578-1592.e16

Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.

He K, Hu Y, Ma H, Zou Z, Xiao Y, Yang Y, Feng M, Li X, Ye X
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709

Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.

He K, Li X, Xiao Y, Yong Y, Zhang Z, Li S, Zhou T, Yang D, Gao P, Xin X
Food & function 2016 Aug 10;7(8):3505-15

The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters.

He K, Ye X, Wu H, Wang Y, Zou Z, Ning N, Hu Y, Chen B, Fang X, Li X
Lipids 2015 Feb;50(2):185-94

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-SLC10A2 (IP:25245-1-AP, 4ug; Detection:25245-1-AP 1:300) with mouse kidney tissue lysate 4000ug.
Other comments: IP
Appendix: 25245-1-AP.pdf

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