676102

antibody from BioLegend
Targeting: SATB1
Provider product page for 676102
Western blot
Immunocytochemistry

Antibody data

Product number
676102 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#676102, RRID:AB_2565610
Product name
Purified anti-SATB1
Antibody type
Monoclonal
Antigen
Full length recombinant human SATB1 (NP_002962) produced in HEK293T cells.
Description
SATB1 is a global regulator that selectively tethers multiple genomic loci and recruits chromatin-remodeling enzymes (e.g. ACF, ISWI, HDAC1 and histone acetyltransferase) to control chromatin structure and gene expression. SATB1 also recruits corepressors or coactivators to promoters. These two opposing interactions, however, are determined by whether or not the SATB1 is phosphorylated by protein kinase C. Unphosphorylated and phosphorylated SATB1 preferably binds to PCAF and HDAC1, respectively. SATB1 also forms a regulatory complex with the promyelocytic leukaemia (PML) protein to organize the major histocompatibility complex (MHC) class I locus into distinct chromatin-loop architecture and mediate the expression of a subset of MHC class I genes. Upon Th2 cell activation, SATB1 expression is induced to compact chromatin into dense-loop structure and to prompt the expression of IL-4, IL-5, IL-13 and c-Maf. Research found that SATB1 is crucial for the growth and metastasis of breast cancer and is a potential prognostic marker.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
O96C6
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
SATB1 protein structure - 676102 shown in red.