21850-1-AP

antibody from Proteintech Group

Targeting: ROCK1 p160ROCK

Provider product page for 21850-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [88]
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Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 21850-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21850-1-AP, RRID:AB_10953526
Product name: ROCK1 antibody
Antibody type: Polyclonal
Description: KD/KO validated ROCK1 antibody (Cat. #21850-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ROCK1 protein structure - 21850-1-AP shown in red.

Submitted references Human Placental Mesenchymal Stem Cells-Exosomes Alleviate Endothelial Barrier Dysfunction via Cytoskeletal Remodeling through hsa-miR-148a-3p/ROCK1 Pathway.

Lv Y, Yu W, Xuan R, Yang Y, Xue X, Ma X
Stem cells international 2024;2024:2172632

Fasudil attenuates oxidative stress-induced partial epithelial-mesenchymal transition of tubular epithelial cells in hyperuricemic nephropathy via activating Nrf2.

Cao Y, Wang Y, Li W, Feng J, Chen Y, Chen R, Hu L, Wei J
European journal of pharmacology 2024 Jul 15;975:176640

Artesunate Induces Ferroptosis in Hepatic Stellate Cells and Alleviates Liver Fibrosis via the ROCK1/ATF3 Axis.

Wang Y, Li Y, Qiu Y, Shen M, Wang L, Shao J, Zhang F, Xu X, Zhang Z, Guo M, Zheng S
Journal of clinical and translational hepatology 2024 Jan 28;12(1):36-51

Targeting ROCK1 in diabetic kidney disease: Unraveling mesangial fibrosis mechanisms and introducing myricetin as a novel antagonist.

Yuan N, Diao J, Dong J, Yan Y, Chen Y, Yan S, Liu C, He Z, He J, Zhang C, Wang H, Wang M, He F, Xiao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Feb;171:116208

Berberine promotes lacteal junction zippering and ameliorates diet-induced obesity through the RhoA/ROCK signaling pathway.

Wang H, Chen S, Tang Y, Nie K, Gao Y, Wang Z, Su H, Wu F, Gong J, Fang K, Dong H, Hu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155268

A New Modulator of Neuroinflammation in Diabetic Retinopathy: USP25.

Hu Q, Zhang X, Peng H, Guan J, Huang Z, Jiang B, Sun D
Inflammation 2024 Aug;47(4):1520-1535

High Hydrostatic Pressure Exacerbates Bladder Fibrosis through Activating Piezo1.

Deng BL, Lin DX, Li ZP, Li K, Wei PY, Luo CC, Zhang MY, Zhou Q, Yang ZL, Chen Z
Current medical science 2024 Aug;44(4):718-725

Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory programs.

Kersey AL, Cheng DY, Deo KA, Dubell CR, Wang TC, Jaiswal MK, Kim MH, Murali A, Hargett SE, Mallick S, Lele TP, Singh I, Gaharwar AK
Biomaterials 2024 Apr;306:122473

GTPBP8 modulates mitochondrial fission through a Drp1-dependent process.

He X, Wang L, Tsang HY, Liu X, Yang X, Pu S, Guo Z, Yang C, Wu Q, Zhou Z, Cen X, Zhao H
Journal of cell science 2024 Apr 15;137(8)

Ellagic acid alleviates TNBS-induced intestinal barrier dysfunction by regulating mucin secretion and maintaining tight junction integrity in rats.

Peng B, Xue L, Yu Q, Zhong T
International journal of food sciences and nutrition 2023;74(4):476-486

Electric field promotes dermal fibroblast transdifferentiation through activation of RhoA/ROCK1 pathway.

Wang W, Huang W, Liu J, Zhang Z, Ji R, Wu C, Zhang J, Jiang X
International journal of medical sciences 2023;20(10):1326-1335

Dahuang-Taoren, a botanical drug combination, ameliorates adenomyosis via inhibiting Rho GTPases.

Lei Y, Fu X, Chen M, Yi Y, Mao P, Peng L, Qu Z
Frontiers in pharmacology 2023;14:1089004

Ruscogenin ameliorates dasatinib-induced intestinal barrier dysfunction via ErbB4/YAP and ROCK/MLC pathways.

Huang J, Zhou J, Dai Y, Liu Y, Li F, Gong S, Zhang Y, Kou J
Journal of natural medicines 2023 Sep;77(4):735-747

Oroxylin a promoted apoptotic extracellular vesicles transfer of glycolytic kinases to remodel immune microenvironment in hepatocellular carcinoma model.

Wang P, Cao J, Feng Z, Tang Y, Han X, Mao T, Li S, Guo Q, Ke X, Zhang X
European journal of pharmacology 2023 Oct 15;957:176037

BioE3 identifies specific substrates of ubiquitin E3 ligases.

Barroso-Gomila O, Merino-Cacho L, Muratore V, Perez C, Taibi V, Maspero E, Azkargorta M, Iloro I, Trulsson F, Vertegaal ACO, Mayor U, Elortza F, Polo S, Barrio R, Sutherland JD
Nature communications 2023 Nov 23;14(1):7656

A novel coumarin derivative DBH2 inhibits proliferation and induces apoptosis of chronic myeloid leukemia cells.

Xin J, Zhang H, Yin D, An N, Chen Y, Xu J, Zhang J, Liu Z, Liu Y, Yin W, Li M, Hu X
Genes & diseases 2023 Mar;10(2):596-607

Xinfuli granule alleviates metabolic remodeling through inhibition of endoplasmic reticulum stress and mitochondrial injury in heart failure.

Su YN, Lu PP, Yan SY, Guo XT, Ma J, Guo CX, Ma LH
Journal of ethnopharmacology 2023 Mar 1;303:115782

Downregulation of HAS‑2 regulates the chondrocyte cytoskeleton and induces cartilage degeneration by activating the RhoA/ROCK signaling pathway.

Yang J, Wang L, Zhang Z, Sun Q, Zhang Y
International journal of molecular medicine 2023 Jul;52(1)

QKI shuttles internal m(7)G-modified transcripts into stress granules and modulates mRNA metabolism.

Zhao Z, Qing Y, Dong L, Han L, Wu D, Li Y, Li W, Xue J, Zhou K, Sun M, Tan B, Chen Z, Shen C, Gao L, Small A, Wang K, Leung K, Zhang Z, Qin X, Deng X, Xia Q, Su R, Chen J
Cell 2023 Jul 20;186(15):3208-3226.e27

The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells.

Takahashi-Kanemitsu A, Lu M, Knight CT, Yamamoto T, Hayashi T, Mii Y, Ooki T, Kikuchi I, Kikuchi A, Barker N, Susaki EA, Taira M, Hatakeyama M
Science signaling 2023 Jul 18;16(794):eabp9020

Morphological and Functional Colonic Defects Caused by a Mutated Thyroid Hormone Receptor α.

Kim M, Kruhlak M, Hoffmann V, Zerfas P, Bishop K, Doolittle WKL, Edmondson EF, Zhu YJ, Cheng SY
Thyroid : official journal of the American Thyroid Association 2023 Feb;33(2):239-250

Stigmasterol protects human brain microvessel endothelial cells against ischemia-reperfusion injury through suppressing EPHA2 phosphorylation.

Li S, Xu F, Yu L, Yu Q, Yu N, Fu J
Chinese journal of natural medicines 2023 Feb;21(2):127-135

RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling.

Zhu H, Wen Z, Zhang A, Liu D, Wang H, Cheng Y, Yang X, Xiao Y, Li J, Sun D, Wu B, Gao J
Communications biology 2023 Feb 23;6(1):214

Biodegradable nano black phosphorus based SDF1-α delivery system ameliorates Erectile Dysfunction in a cavernous nerve injury rat model by recruiting endogenous stem/progenitor cells.

Fu Q, Song L, Li J, Yi B, Huang Y, Zhang Z, Xin Z, Zhu J
Journal of nanobiotechnology 2023 Dec 18;21(1):487

Diosmetin alleviates acute lung injury caused by lipopolysaccharide by targeting barrier function.

Xia J, Li J, Deng M, Yin F, Liu J, Wang J
Inflammopharmacology 2023 Aug;31(4):2037-2047

Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota.

Li K, Wu J, Xu S, Li X, Zhang Y, Gao XJ
Microbiology spectrum 2023 Aug 18;11(5):e0191423

Tetrandrine Attenuates Podocyte Injury by Inhibiting TRPC6-Mediated RhoA/ROCK1 Pathway.

Mao L, Ding Y, Yu D, Yin J, Yu J
Analytical cellular pathology (Amsterdam) 2022;2022:7534181

Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis.

Lin D, Zhang M, Luo C, Wei P, Cui K, Chen Z
Journal of immunology research 2022;2022:6833867

GLP-1 RA Improves Diabetic Retinopathy by Protecting the Blood-Retinal Barrier through GLP-1R-ROCK-p-MLC Signaling Pathway.

Wei L, Mo W, Lan S, Yang H, Huang Z, Liang X, Li L, Xian J, Xie X, Qin Y, Lin F, Luo Z
Journal of diabetes research 2022;2022:1861940

Tissue Kallikrein Protects Rat Prostate against the Inflammatory Damage in a Chronic Autoimmune Prostatitis Model via Restoring Endothelial Function in a Bradykinin Receptor B2-Dependent Way.

Zhang M, Lin D, Luo C, Wei P, Cui K, Chen Z
Oxidative medicine and cellular longevity 2022;2022:1247806

Poly (ADP-ribose) polymerase 1 (PARP1) inhibition promotes pulmonary metastasis of osteosarcoma by boosting ezrin phosphorylation.

Li F, Wu X, Fu X, Liu J, Song W, Xiao GG, Lu A, Zhang G
International journal of biological sciences 2022;18(3):1238-1253

The Cytoskeleton Effectors Rho-Kinase (ROCK) and Mammalian Diaphanous-Related (mDia) Formin Have Dynamic Roles in Tumor Microtube Formation in Invasive Glioblastoma Cells.

Becker KN, Pettee KM, Sugrue A, Reinard KA, Schroeder JL, Eisenmann KM
Cells 2022 May 5;11(9)

Oxycodone relieves permeability damage and apoptosis of oxygen-glucose deprivation/reoxygenation-induced brain microvascular endothelial cells through ras homolog family member A (RhoA)/ Rho-associated coiled-coil containing kinases (ROCK)/ myosin light chain 2 (MLC2) signal.

Shao F, Han D, Shen Y, Bian W, Zou L, Hu Y, Sun W
Bioengineered 2022 Mar;13(3):5205-5215

Acetyl-L-carnitine improves erectile function in bilateral cavernous nerve injury rats via promoting cavernous nerve regeneration.

Wang J, Song J, Song G, Feng Y, Pan J, Yang X, Xin Z, Hu P, Sun T, Liu K, Xu W, Wang T, Wang S, Liu J, Ruan Y
Andrology 2022 Jul;10(5):984-996

G-protein Coupled Receptor 34 Promotes Gliomagenesis by Inducing Proliferation and Malignant Phenotype via TGF-Beta/Smad Signaling Pathway.

Cheng Y, Heng X, Feng F
Technology in cancer research & treatment 2022 Jan-Dec;21:15330338221105733

Uncaria Rhynchophylla attenuates angiotensin Ⅱ-induced myocardial fibrosis via suppression of the RhoA/ROCK1 pathway.

Xie L, Wang T, Lin S, Lu Z, Wang Y, Shen Z, Cheng Y, Shen A, Peng J, Chu J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Feb;146:112607

Berberine Depresses Inflammation and Adjusts Smooth Muscle to Ameliorate Ulcerative Colitis of Cats by Regulating Gut Microbiota.

Li X, Xu S, Zhang Y, Li K, Gao XJ, Guo MY
Microbiology spectrum 2022 Dec 21;10(6):e0320722

Shenqihuatan formula reduces inflammation by inhibiting transforming growth factor-beta-stimulated signaling pathway in airway smooth muscle cells.

Jingjing C, Yuanyuan W, Nianzhi Z, Xiaoming X
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Aug;42(4):520-529

Echinococcus multilocularis drives the polarization of macrophages by regulating the RhoA-MAPK signaling pathway and thus affects liver fibrosis.

Chong S, Chen G, Dang Z, Niu F, Zhang L, Ma H, Zhao Y
Bioengineered 2022 Apr;13(4):8747-8758

FMNL2 suppresses cell migration and invasion of breast cancer: a reduction of cytoplasmic p27 via RhoA/LIMK/Cofilin pathway.

Jiao X, Wang B, Yang L, Zhao Q, Zhang M, Liu X, Zhou C, Wang R, Chen H, Wang J, Ren Y, Liu P
Cell death discovery 2022 Apr 4;8(1):155

CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/β-Catenin Signaling Pathway in Glioma.

Feng F, Zhao Z, Zhou Y, Cheng Y, Wu X, Heng X
Frontiers in molecular biosciences 2021;8:705008

Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates.

Zhang M, Luo C, Lin D, Cui K, Chen Z, Liu J
Oxidative medicine and cellular longevity 2021;2021:8877540

PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease.

Zhang Z, Liang W, Luo Q, Hu H, Yang K, Hu J, Chen Z, Zhu J, Feng J, Zhu Z, Chi Q, Ding G
Frontiers in endocrinology 2021;12:797025

Silencing of ANGPTL8 Alleviates Insulin Resistance in Trophoblast Cells.

Bai Y, Du Q, Zhang L, Li L, Wang N, Wu B, Li P, Li L
Frontiers in endocrinology 2021;12:635321

CHD8 safeguards early neuroectoderm differentiation in human ESCs and protects from apoptosis during neurogenesis.

Ding S, Lan X, Meng Y, Yan C, Li M, Li X, Chen J, Jiang W
Cell death & disease 2021 Oct 22;12(11):981

Injectable self-assembling peptide nanofiber hydrogel as a bioactive 3D platform to promote chronic wound tissue regeneration.

Lou P, Liu S, Wang Y, Pan C, Xu X, Zhao M, Liao G, Yang G, Yuan Y, Li L, Zhang J, Chen Y, Cheng J, Lu Y, Liu J
Acta biomaterialia 2021 Nov;135:100-112

The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.

Yue XF, Shen CX, Wang JW, Dai LY, Fang Q, Long L, Zhi Y, Li XR, Wang YW, Shen GF, Liu ZJ, Shi CM, Li WB
Asian journal of andrology 2021 May-Jun;23(3):249-258

TROAP regulates cell cycle and promotes tumor progression through Wnt/β-Catenin signaling pathway in glioma cells.

Zhao ZQ, Wu XJ, Cheng YH, Zhou YF, Ma XM, Zhang J, Heng XY, Feng F
CNS neuroscience & therapeutics 2021 Jun 2;27(9):1064-76

Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer.

Bin J, Nie S, Tang Z, Kang A, Fu Z, Hu Y, Liao Q, Xiong W, Zhou Y, Tang Y, Jiang J
Journal of cellular physiology 2021 Jan;236(1):523-535

The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.

Ke W, Wang B, Hua W, Song Y, Lu S, Luo R, Li G, Wang K, Liao Z, Xiang Q, Li S, Wu X, Zhang Y, Yang C
Cell proliferation 2021 Feb;54(2):e12987

The miR-136-5p/ROCK1 axis suppresses invasion and migration, and enhances cisplatin sensitivity in head and neck cancer cells.

Yang B, Zang J, Yuan W, Jiang X, Zhang F
Experimental and therapeutic medicine 2021 Apr;21(4):317

Tetrandrine Suppresses Transient Receptor Potential Cation Channel Protein 6 Overexpression- Induced Podocyte Damage via Blockage of RhoA/ROCK1 Signaling.

Yu J, Zhu C, Yin J, Yu D, Wan F, Tang X, Jiang X
Drug design, development and therapy 2020;14:361-370

TMED3 Promotes Proliferation and Migration in Breast Cancer Cells by Activating Wnt/β-Catenin Signaling.

Zhang X, Luo Y, Li Q
OncoTargets and therapy 2020;13:5819-5830

Liraglutide Ameliorates Erectile Dysfunction via Regulating Oxidative Stress, the RhoA/ROCK Pathway and Autophagy in Diabetes Mellitus.

Yuan P, Ma D, Gao X, Wang J, Li R, Liu Z, Wang T, Wang S, Liu J, Liu X
Frontiers in pharmacology 2020;11:1257

Chronic inflammation promotes proliferation in the prostatic stroma in rats with experimental autoimmune prostatitis: study for a novel method of inducing benign prostatic hyperplasia in a rat model.

Zhang M, Luo C, Cui K, Xiong T, Chen Z
World journal of urology 2020 Nov;38(11):2933-2943

Long noncoding RNA LINC00346 promotes glioma cell migration, invasion and proliferation by up-regulating ROCK1.

Chen X, Li D, Chen L, Hao B, Gao Y, Li L, Zhou C, He X, Cao Y
Journal of cellular and molecular medicine 2020 Nov;24(22):13010-13019

JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type Ⅰ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis.

Liu K, Cui K, Feng H, Li R, Lin H, Chen Y, Zhang Y, Chen Z, Yuan H, Li M, Wang T, Lan R, Liu J, Rao K, Wen B
Andrology 2020 Mar;8(2):497-508

Lysophosphatidic acid receptor 4 regulates osteogenic and adipogenic differentiation of progenitor cells via inactivation of RhoA/ROCK1/β-catenin signaling.

Xie Y, Wang X, Wu X, Tian L, Zhou J, Li X, Wang B
Stem cells (Dayton, Ohio) 2020 Mar;38(3):451-463

Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function.

Wang L, Yu P, Zhou B, Song J, Li Z, Zhang M, Guo G, Wang Y, Chen X, Han L, Hu S
Nature cell biology 2020 Jan;22(1):108-119

Thymol alleviates AGEs-induced podocyte injury by a pleiotropic effect via NF-κB-mediated by RhoA/ROCK signalling pathway.

Wang Q, Shen Z, Qi G, Zhao Y, Zhang H, Wang R
Cell adhesion & migration 2020 Dec;14(1):42-56

Spider venom components decrease glioblastoma cell migration and invasion through RhoA-ROCK and Na(+)/K(+)-ATPase β2: potential molecular entities to treat invasive brain cancer.

Barreto N, Caballero M, Bonfanti AP, de Mato FCP, Munhoz J, da Rocha-E-Silva TAA, Sutti R, Vitorino-Araujo JL, Verinaud L, Rapôso C
Cancer cell international 2020 Dec 17;20(1):576

Activation of leukocyte immunoglobulin-like receptor B2 signaling pathway in cortical lesions of pediatric patients with focal cortical dysplasia type IIb and tuberous sclerosis complex.

Yue J, Zhang C, Shi X, Wei Y, Liu L, Liu S, Yang H
Brain & development 2019 Nov;41(10):829-838

Effects of RhoC downregulation on the angiogenesis characteristics of myeloma vascular endothelial cells.

Zhao Z, Liu K, Tian X, Sun M, Wei N, Zhu X, Yang H, Wang T, Jiang G, Chen K
Cancer medicine 2019 Jul;8(7):3502-3510

Chondroitin sulfate proteoglycan represses neural stem/progenitor cells migration via PTPσ/α-actinin4 signaling pathway.

Zhong J, Lan C, Zhang C, Yang Y, Chen WX, Zhang KY, Zhao HL, Fang XY, Li HH, Tan L, Wang P, Ge HF, Hu R, Feng H
Journal of cellular biochemistry 2019 Jul;120(7):11008-11021

RAB35 depletion affects spindle formation and actin-based spindle migration in mouse oocyte meiosis.

Zhang Y, Wan X, Wang HH, Pan MH, Pan ZN, Sun SC
Molecular human reproduction 2019 Jul 1;25(7):359-372

Overexpression of CDCA8 promotes the malignant progression of cutaneous melanoma and leads to poor prognosis.

Ci C, Tang B, Lyu D, Liu W, Qiang D, Ji X, Qiu X, Chen L, Ding W
International journal of molecular medicine 2019 Jan;43(1):404-412

Increased levels of serum pigment epithelium-derived factor aggravate proteinuria via induction of podocyte actin rearrangement.

Huang N, Zhang X, Jiang Y, Mei H, Zhang L, Zhang Q, Hu J, Chen B
International urology and nephrology 2019 Feb;51(2):359-367

ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness.

Peng Y, Chen Z, Chen Y, Li S, Jiang Y, Yang H, Wu C, You F, Zheng C, Zhu J, Tan Y, Qin X, Liu Y
Acta biomaterialia 2019 Apr 1;88:86-101

Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology.

Zhang J, Zhang Q, Chen X, Liu Y, Xue J, Dahan A, Zhang H, Chai Y
Evidence-based complementary and alternative medicine : eCAM 2018;2018:6503126

Carcinoma associated fibroblasts (CAFs) promote breast cancer motility by suppressing mammalian Diaphanous-related formin-2 (mDia2).

Dvorak KM, Pettee KM, Rubinic-Minotti K, Su R, Nestor-Kalinoski A, Eisenmann KM
PloS one 2018;13(3):e0195278

Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.

Song H, Guo T, Zhao Z, Wei Y, Luo H, Weng W, Zhang R, Zhong M, Chen C, Su J, Shen W
Biomaterials 2018 Sep;178:23-35

miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene.

Li Y, Zhang H, Gong H, Yuan Y, Li Y, Wang C, Li W, Zhang Z, Liu M, Liu H, Chen J
Journal of experimental & clinical cancer research : CR 2018 Jul 9;37(1):141

Androgen deficiency impairs erectile function in rats through promotion of corporal fibrosis.

Cui K, Li R, Chen R, Li M, Wang T, Yang J, Chen Z, Wang S, Liu J, Rao K
Andrologia 2018 Feb;50(1)

Megakaryocytic Smad4 Regulates Platelet Function through Syk and ROCK2 Expression.

Wang Y, Jiang L, Mo X, Lan Y, Yang X, Liu X, Zhang J, Zhu L, Liu J, Wu X
Molecular pharmacology 2017 Sep;92(3):285-296

FTY720 Supplementation Partially Improves Erectile Dysfunction in Rats With Streptozotocin-Induced Type 1 Diabetes Through Inhibition of Endothelial Dysfunction and Corporal Fibrosis.

Cui K, Ruan Y, Wang T, Rao K, Chen Z, Wang S, Liu J
The journal of sexual medicine 2017 Mar;14(3):323-335

Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents.

Zhu J, Xu M, Gao M, Zhang Z, Xu Y, Xia T, Liu S
ACS nano 2017 Mar 28;11(3):2637-2651

Dihydroartemisinin counteracts fibrotic portal hypertension via farnesoid X receptor-dependent inhibition of hepatic stellate cell contraction.

Xu W, Lu C, Zhang F, Shao J, Yao S, Zheng S
The FEBS journal 2017 Jan;284(1):114-133

Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1.

Cui K, Luan Y, Wang T, Zhuan L, Rao K, Wang SG, Ye ZQ, Liu JH, Wang DW
Asian journal of andrology 2017 Jan-Feb;19(1):67-72

miR-150 is downregulated in osteosarcoma and suppresses cell proliferation, migration and invasion by targeting ROCK1.

Li CH, Yu TB, Qiu HW, Zhao X, Zhou CL, Qi C
Oncology letters 2017 Apr;13(4):2191-2197

Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NO/cGMP Pathways and Rho-Associated Kinases Expression.

He Y, Xia P, Jin H, Zhang Y, Chen B, Xu Z
Oxidative medicine and cellular longevity 2016;2016:3128280

CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells.

Liu Z, Chu S, Yao S, Li Y, Fan S, Sun X, Su L, Liu X
Oncotarget 2016 Oct 18;7(42):68303-68313

Activation of LILRB2 signal pathway in temporal lobe epilepsy patients and in a pilocarpine induced epilepsy model.

Yue J, Li W, Liang C, Chen B, Chen X, Wang L, Zang Z, Yu S, Liu S, Li S, Yang H
Experimental neurology 2016 Nov;285(Pt A):51-60

Regulation of the RhoA/ROCK/AKT/β-catenin pathway by arginine-specific ADP-ribosytransferases 1 promotes migration and epithelial-mesenchymal transition in colon carcinoma.

Song GL, Jin CC, Zhao W, Tang Y, Wang YL, Li M, Xiao M, Li X, Li QS, Lin X, Chen WW, Kuang J
International journal of oncology 2016 Aug;49(2):646-56

miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis.

Chen K, He H, Xie Y, Zhao L, Zhao S, Wan X, Yang W, Mo Z
Scientific reports 2015 Jul 7;5:11909

DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.

Huang W, Liu J, Feng X, Chen H, Zeng L, Huang G, Liu W, Wang L, Jia W, Chen J, Ren C
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115

Overexpression of RNF146 in non-small cell lung cancer enhances proliferation and invasion of tumors through the Wnt/β-catenin signaling pathway.

Gao Y, Song C, Hui L, Li CY, Wang J, Tian Y, Han X, Chen Y, Tian DL, Qiu X, Wang E
PloS one 2014;9(1):e85377

Synergistic effect of arginine-specific ADP-ribosyltransferase 1 and poly(ADP-ribose) polymerase-1 on apoptosis induced by cisplatin in CT26 cells.

Kuang J, Wang YL, Xiao M, Tang Y, Chen WW, Song GL, Yang X, Li M
Oncology reports 2014 May;31(5):2335-43

DEK depletion negatively regulates Rho/ROCK/MLC pathway in non-small cell lung cancer.

Wang J, Sun L, Yang M, Luo W, Gao Y, Liu Z, Qiu X, Wang E
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2013 Jul;61(7):510-21

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 21850-1-AP(ROCK1 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human lung cancer using 21850-1-AP(ROCK1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ROCK1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ROCK1. This antibody recognizes human,mouse,rat antigen. The ROCK1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 21850-1-AP.pdf

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