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- Antibody Data
- Antigen structure
- References [5]
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- Validations
- Western blot [1]
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- Product number
- HPA007567 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA007567, RRID:AB_1856393
- Product name
- Anti-ROCK1
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human ROCK1, Gene description: Rho-associated, coiled-coil containing protein kinase 1, Alternative Gene Names: p160ROCK, Validated applications: WB, IHC, Uniprot ID: Q13464, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.2 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Selectivity matters: selective ROCK2 inhibitor ameliorates established liver fibrosis via targeting inflammation, fibrosis, and metabolism
Blockade of 20-hydroxyeicosatetraenoic acid receptor lowers blood pressure and alters vascular function in mice with smooth muscle-specific overexpression of CYP4A12-20-HETE synthase
Impact of RhoA overexpression on clinical outcomes in cervical squamous cell carcinoma treated with concurrent chemoradiotherapy.
Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells
Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10
Zanin-Zhorov A, Chen W, Moretti J, Nyuydzefe M, Zhorov I, Munshi R, Ghosh M, Serdjebi C, MacDonald K, Blazar B, Palmer M, Waksal S
Communications Biology 2023;6(1)
Communications Biology 2023;6(1)
Blockade of 20-hydroxyeicosatetraenoic acid receptor lowers blood pressure and alters vascular function in mice with smooth muscle-specific overexpression of CYP4A12-20-HETE synthase
Agostinucci K, Hutcheson R, Hossain S, Pascale J, Villegas E, Zhang F, Adebesin A, Falck J, Gupte S, Garcia V, Schwartzman M
Journal of Hypertension 2022;40(3):498-511
Journal of Hypertension 2022;40(3):498-511
Impact of RhoA overexpression on clinical outcomes in cervical squamous cell carcinoma treated with concurrent chemoradiotherapy.
Tanaka K, Matsumoto Y, Ishikawa H, Fukumitsu N, Numajiri H, Murofushi K, Oshiro Y, Okumura T, Satoh T, Sakurai H
Journal of radiation research 2020 Mar 23;61(2):221-230
Journal of radiation research 2020 Mar 23;61(2):221-230
Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells
Ito S, Okuda S, Abe M, Fujimoto M, Onuki T, Nishimura T, Takeichi M
Nature Communications 2017;8(1)
Nature Communications 2017;8(1)
Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10
Zanin-Zhorov A, Weiss J, Trzeciak A, Chen W, Zhang J, Nyuydzefe M, Arencibia C, Polimera S, Schueller O, Fuentes-Duculan J, Bonifacio K, Kunjravia N, Cueto I, Soung J, Fleischmann R, Kivitz A, Lebwohl M, Nunez M, Woodson J, Smith S, West R, Berger M, Krueger J, Ryan J, Waksal S
The Journal of Immunology 2017;198(10):3809-3814
The Journal of Immunology 2017;198(10):3809-3814
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Enhanced validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Genetic validation
- Main image
- Experimental details
- Western blot analysis in U-138MG cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-ROCK1 antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.
- Sample type
- Human
- Protocol
- Protocol
