Explore
Validate
Learn10297-1-AP
antibody from Proteintech Group
Targeting: AURKA
AIK, ARK1, AurA, BTAK, PPP1R47, STK15, STK6, STK7
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 10297-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10297-1-AP, RRID:AB_2061337
- Product name
- Aurora A antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Aurora A antibody (Cat. #10297-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references AURKA Enhances Antitumor Immunity by Activating CD4+ T Cell Proliferation in Colorectal Cancer.
Integrated transcriptomic and immunoinformatics analysis identifies tpx2, bub1b, and ube2c as diagnostic biomarkers and therapeutic targets in endometrial carcinoma.
The expression and prognosis for Aurora kinases in human non-small cell lung cancer.
Revealing the active ingredients and mechanisms of Xiatianwu against hepatocellular carcinoma: a study based on network pharmacology and bioinformatics.
Structure-Based Rational Design and Evaluation of BET-Aurora Kinase Dual-Inhibitors for Treatment of Cancers.
Aurora A degradation by HSP90 interactome-mediating PROTACs in A549 and paclitaxel-resistant A549 cells.
Palmatine attenuates MYH9 mediated nuclear localization of AURKA to induce G2/M phase arrest in colorectal cancer cells.
The mechanism of acentrosomal spindle assembly in human oocytes.
The phytochemical, corynoline, diminishes Aurora kinase B activity to induce mitotic defect and polyploidy.
Aurora-A/FOXO3A/SKP2 axis promotes tumor progression in clear cell renal cell carcinoma and dual-targeting Aurora-A/SKP2 shows synthetic lethality.
CPEB1 directs muscle stem cell activation by reprogramming the translational landscape.
The ALDH Family Contributes to Immunocyte Infiltration, Proliferation and Epithelial-Mesenchymal Transformation in Glioma.
Investigation on the clinical efficacy and mechanism of compound kushen injection in treating esophageal cancer based on multi-dimensional network meta-analysis and in vitro experiment.
Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway.
Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma.
Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest.
The Phytochemical Scoulerine Inhibits Aurora Kinase Activity to Induce Mitotic and Cytokinetic Defects.
AURKA Increase the Chemosensitivity of Colon Cancer Cells to Oxaliplatin by Inhibiting the TP53-Mediated DNA Damage Response Genes.
Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.
MiR-26a-5p Inhibits Cell Proliferation and Enhances Doxorubicin Sensitivity in HCC Cells via Targeting AURKA.
Receptor tyrosine kinase expression in high-grade gliomas before and after chemoradiotherapy.
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase.
Co-expression of mitosis-regulating genes contributes to malignant progression and prognosis in oligodendrogliomas.
A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens.
Xu Y, Wang W, Yu J, Zhao J, Dai X, Liu Z
Cancer investigation 2025 Oct;43(9):740-757
Cancer investigation 2025 Oct;43(9):740-757
Integrated transcriptomic and immunoinformatics analysis identifies tpx2, bub1b, and ube2c as diagnostic biomarkers and therapeutic targets in endometrial carcinoma.
Zhou S, Sun J, Li J, Zhou X, Shi X, Yang M, Wang Y, Zhang J
Discover oncology 2025 Oct 27;16(1):1975
Discover oncology 2025 Oct 27;16(1):1975
The expression and prognosis for Aurora kinases in human non-small cell lung cancer.
Wang Y, Liu J, Xu J, Ji Z
Discover oncology 2025 Jun 6;16(1):1021
Discover oncology 2025 Jun 6;16(1):1021
Revealing the active ingredients and mechanisms of Xiatianwu against hepatocellular carcinoma: a study based on network pharmacology and bioinformatics.
Wang H, Zhang W, Li L, Wang H, Jiang H, Li W, Huang J, Wan Y
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jan;398(1):729-746
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jan;398(1):729-746
Structure-Based Rational Design and Evaluation of BET-Aurora Kinase Dual-Inhibitors for Treatment of Cancers.
Lyu K, Ren Y, Mou J, Yang Y, Pan Y, Zhang H, Li Y, Cao D, Chen L, Chen D, Guo D, Xiong B
Journal of medicinal chemistry 2025 Jan 23;68(2):1344-1364
Journal of medicinal chemistry 2025 Jan 23;68(2):1344-1364
Aurora A degradation by HSP90 interactome-mediating PROTACs in A549 and paclitaxel-resistant A549 cells.
Deng XY, Xu H, Peng YX, Guo YY, He RF, Lu G
European journal of medicinal chemistry 2025 Dec 15;300:118141
European journal of medicinal chemistry 2025 Dec 15;300:118141
Palmatine attenuates MYH9 mediated nuclear localization of AURKA to induce G2/M phase arrest in colorectal cancer cells.
Tang W, Li J, Zhou Y, Li J, Ma Z, Li X, Wang H, Xiong M, Chen X, Li X, Chen W, Ma H, Ye X
International immunopharmacology 2024 Dec 25;143(Pt 3):113615
International immunopharmacology 2024 Dec 25;143(Pt 3):113615
The mechanism of acentrosomal spindle assembly in human oocytes.
Wu T, Dong J, Fu J, Kuang Y, Chen B, Gu H, Luo Y, Gu R, Zhang M, Li W, Dong X, Sun X, Sang Q, Wang L
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
The phytochemical, corynoline, diminishes Aurora kinase B activity to induce mitotic defect and polyploidy.
Yan Z, Shi Q, Liu X, Li J, Ahire V, Zhang S, Zhang J, Yang D, Allen TD
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Mar;147:112645
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Mar;147:112645
Aurora-A/FOXO3A/SKP2 axis promotes tumor progression in clear cell renal cell carcinoma and dual-targeting Aurora-A/SKP2 shows synthetic lethality.
Li P, Chen T, Kuang P, Liu F, Li Z, Liu F, Wang Y, Zhang W, Cai X
Cell death & disease 2022 Jul 13;13(7):606
Cell death & disease 2022 Jul 13;13(7):606
CPEB1 directs muscle stem cell activation by reprogramming the translational landscape.
Zeng W, Yue L, Lam KSW, Zhang W, So WK, Tse EHY, Cheung TH
Nature communications 2022 Feb 17;13(1):947
Nature communications 2022 Feb 17;13(1):947
The ALDH Family Contributes to Immunocyte Infiltration, Proliferation and Epithelial-Mesenchymal Transformation in Glioma.
Wang Z, Mo Y, Tan Y, Wen Z, Dai Z, Zhang H, Zhang X, Feng S, Liang X, Song T, Cheng Q
Frontiers in immunology 2021;12:756606
Frontiers in immunology 2021;12:756606
Investigation on the clinical efficacy and mechanism of compound kushen injection in treating esophageal cancer based on multi-dimensional network meta-analysis and in vitro experiment.
Zhou W, Huang Z, Wu C, Lu S, Fu C, Ye P, Tan Y, Wu Z, Fan X, Zhang J, Guo S, Jia S, Stalin A, Wang H, Zhang X, Wang M, Wu J
Journal of ethnopharmacology 2021 Oct 28;279:114386
Journal of ethnopharmacology 2021 Oct 28;279:114386
Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway.
Zheng X, Li W, Xu H, Liu J, Ren L, Yang Y, Li S, Wang J, Ji T, Du G
Acta pharmaceutica Sinica. B 2021 Nov;11(11):3465-3480
Acta pharmaceutica Sinica. B 2021 Nov;11(11):3465-3480
Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma.
Shi K, Zhang JZ, Yang L, Li NN, Yue Y, Du XH, Zhang XZ, Lu YC, Guo D
BMC cancer 2021 Nov 10;21(1):1196
BMC cancer 2021 Nov 10;21(1):1196
Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest.
Liu JY, Fu WQ, Zheng XJ, Li W, Ren LW, Wang JH, Yang C, Du GH
Acta pharmacologica Sinica 2021 Jan;42(1):97-107
Acta pharmacologica Sinica 2021 Jan;42(1):97-107
The Phytochemical Scoulerine Inhibits Aurora Kinase Activity to Induce Mitotic and Cytokinetic Defects.
Li J, Yan Z, Li H, Shi Q, Ahire V, Zhang S, Nimishetti N, Yang D, Allen TD, Zhang J
Journal of natural products 2021 Aug 27;84(8):2312-2320
Journal of natural products 2021 Aug 27;84(8):2312-2320
AURKA Increase the Chemosensitivity of Colon Cancer Cells to Oxaliplatin by Inhibiting the TP53-Mediated DNA Damage Response Genes.
Shan B, Zhao R, Zhou J, Zhang M, Qi X, Wang T, Gong J, Wu Y, Zhu Y, Yang W, Zhang Y, Wang G, Li X
BioMed research international 2020;2020:8916729
BioMed research international 2020;2020:8916729
Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.
Fan C, Zhong T, Yang H, Yang Y, Wang D, Yang X, Xu Y, Fan Y
European journal of medicinal chemistry 2020 Mar 15;190:112108
European journal of medicinal chemistry 2020 Mar 15;190:112108
MiR-26a-5p Inhibits Cell Proliferation and Enhances Doxorubicin Sensitivity in HCC Cells via Targeting AURKA.
Yuan YL, Yu H, Mu SM, Dong YD, Li Y
Technology in cancer research & treatment 2019 Jan 1;18:1533033819851833
Technology in cancer research & treatment 2019 Jan 1;18:1533033819851833
Receptor tyrosine kinase expression in high-grade gliomas before and after chemoradiotherapy.
Wang K, Huang R, Wu C, Li G, Zhao Z, Hu H, Liu Y
Oncology letters 2019 Dec;18(6):6509-6515
Oncology letters 2019 Dec;18(6):6509-6515
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N, Ying M
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase.
Li W, Liu J, Fu W, Zheng X, Ren L, Liu S, Wang J, Ji T, Du G
Journal of experimental & clinical cancer research : CR 2018 Jul 3;37(1):132
Journal of experimental & clinical cancer research : CR 2018 Jul 3;37(1):132
Co-expression of mitosis-regulating genes contributes to malignant progression and prognosis in oligodendrogliomas.
Liu Y, Hu H, Zhang C, Wang H, Zhang W, Wang Z, Li M, Zhang W, Zhou D, Jiang T
Oncotarget 2015 Nov 10;6(35):38257-69
Oncotarget 2015 Nov 10;6(35):38257-69
A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens.
Liu YZ, Jiang YY, Wang BS, Hao JJ, Shang L, Zhang TT, Cao J, Xu X, Zhan QM, Wang MR
Cancer cytopathology 2014 Nov;122(11):833-41
Cancer cytopathology 2014 Nov;122(11):833-41
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10297-1-AP( AURKA Antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Aurora A antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Aurora A. This antibody recognizes human,mouse,rat antigen. The Aurora A antibody has been validated for the following applications: ELISA, IHC, WB analysis.
