ABIN362453

antibody from antibodies-online

Targeting: AURKA AIK, ARK1, AurA, BTAK, PPP1R47, STK15, STK6, STK7

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN362453

Provider

antibodies-online

Product name

anti-Aurora Kinase A (AURKA) (pThr288) antibody

Antibody type

Polyclonal

Antigen

Peptide sequence around phosphorylation site of pThr288 (R-T-T (p) -L-M) derived from Human Aurora A. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human, Mouse

Host

Rabbit

Epitope

pThr288

Isotype

IgG

Vial size

50 μL

Concentration

1 mg/mL

Storage

Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

References

Submitted references

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.

Hauf S, Cole RW, LaTerra S, Zimmer C, Schnapp G, Walter R, Heckel A, van Meel J, Rieder CL, Peters JM
The Journal of cell biology 2003 Apr 28;161(2):281-94

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The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation.

Walter AO, Seghezzi W, Korver W, Sheung J, Lees E
Oncogene 2000 Oct 5;19(42):4906-16

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The war of the sex chromosomes.

Ellis NA
Nature genetics 1998 Sep;20(1):9-10

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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers.

Bischoff JR, Anderson L, Zhu Y, Mossie K, Ng L, Souza B, Schryver B, Flanagan P, Clairvoyant F, Ginther C, Chan CS, Novotny M, Slamon DJ, Plowman GD
The EMBO journal 1998 Jun 1;17(11):3052-65