66757-1-Ig

antibody from Proteintech Group

Targeting: AURKA AIK, ARK1, AurA, BTAK, PPP1R47, STK15, STK6, STK7

Provider product page for 66757-1-Ig

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Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [34]
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Product number: 66757-1-Ig - Provider product page
Provider: Proteintech Group
Product name: AURKA antibody
Antibody type: Monoclonal
Description: AURKA antibody (Cat. #66757-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse, Rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1F4B10
Vial size: 20ul, 150ul

AURKA protein structure - 66757-1-Ig shown in red.

Submitted references Resveratrol inhibits bladder cancer proliferation by targeting the AURKA/STAT3 axis: From computational analysis to experimental validation.

Feng C, Chen G, Shu Y, Chen J, Ye W, Ren L
PloS one 2026;21(1):e0342162

Integrating multiple key molecules in uveal melanoma to uncover metastatic and immune microenvironment-related gene signatures.

Guo YM, Bai ZP, Wang JQ, Huang J, Wei JH, Han YJ, Liu Y, Ye L
International journal of ophthalmology 2026;19(1):11-24

AURKA Activates FOXO3a to Form a Positive Feedback Loop in the Proliferation and Migration of Keloid Fibroblasts.

Chu X, Sun J, Dai S, Liang Y, Qian X, Xu J, Zhang J
Advances in wound care 2026 Mar;15(3):168-180

Adiponectin Inhibits AURKA to Suppress Inflammation in TNF-α-induced Keratinocytes and Attenuates Psoriatic Dermatitis in Mice.

Zhang L, Ke C, Shen Y, Shi F, Jiao Q, Ji J
Immunity, inflammation and disease 2026 Mar;14(3):e70407

SENP5 enhances antiviral innate immunity by promoting AURKA-dependent STAT2 phosphorylation.

Song S, Kan Y, Zhou M, Jiang Y, Tang Y, Luo H, Hu Y
Cell communication and signaling : CCS 2026 Mar 13;24(1)

WGCNA and machine learning identify AURKA, CDK1, and other hub genes associated with immune infiltration as therapeutic targets in GIST: An integrative bioinformatics analysis.

Chen A, Nie H, Li Y, Zhong L, Yang W, Zhang L
Medicine 2026 Jan 2;105(1):e46636

AURKA Enhances Antitumor Immunity by Activating CD4+ T Cell Proliferation in Colorectal Cancer.

Xu Y, Wang W, Yu J, Zhao J, Dai X, Liu Z
Cancer investigation 2025 Oct;43(9):740-757

Pre-rRNAs control mitosis by maintaining chromosomal segregation through protecting SMC2 from AURKA-mediated phosphorylation.

Sun S, Su K, Jiang Y, Wang Y, Hu Y, Wang C, Zhao Z, Zhang C, Xing B, Du X
Cell death & disease 2025 Nov 7;16(1):812

The kinesin motor Kif9 regulates centriolar satellite positioning during interphase.

Vicente JJ, Wagenbach M, Decarreau J, Zelter A, MacCoss MJ, Davis TN, Wordeman L
Current biology : CB 2025 Nov 3;35(21):5119-5135.e4

The DNA-PKcs-primary cilia axis maintains ionizing radiation-induced senescence in tumor cells.

Liu X, Wei L, Zhang R, Chen J, Zhang T, Hua J, Wang J, He J, Xie X
Acta biochimica et biophysica Sinica 2025 Nov 3;

The N-terminal region of HASPIN regulates phosphorylation of AURKA and meiotic progression in spermatocytes.

Li H, Xu Y, Jiang X, Ren J, Wang Y, Zhang X, Gao M, Zhang L, Wang Y, Li Z, Wang S, Wang T, Wang M, Situ C, Guo X, Zhu H
Molecular and cellular endocrinology 2025 Nov 1;609:112645

Aurora kinase A promotes epithelial‑mesenchymal transition by regulating P130 and P107 molecules in thyroid cancer cells.

Yang L, Gao Y, Lu J, Wu G
Experimental and therapeutic medicine 2025 May;29(5):93

BRD4 regulates m(6)A of ESPL1 mRNA via interaction with ALKBH5 to modulate breast cancer progression.

Zhang H, Lu L, Yi C, Jiang T, Lu Y, Yang X, Zhong K, Zhou J, Li J, Xie G, Chen Z, Jiang Z, Asadikaram G, Peng Y, Zhou D, Wang H
Acta pharmaceutica Sinica. B 2025 Mar;15(3):1552-1570

TAK-901, a novel EPHA2 inhibitor as a therapeutic strategy against prostate cancer.

Liu S, Fu S, Wu X, Wu S, Zhao Y, Wu X, Yan L, Lu J, Li L, Tao Y
Cellular signalling 2025 Jul;131:111750

The aberrantly activated AURKB supports and complements the function of AURKA in CALR mutated cells through regulating the cell growth and differentiation.

Hu X, Yu X, Zhang L, Zhang Q, Ji M, Qi K, Wang S, Li Z, Xu K, Fu C
Experimental cell research 2025 Jan 15;444(2):114377

Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies.

Lemay SE, Mougin M, Sauvaget M, El Kabbout R, Valasarajan C, Yamamoto K, Martineau S, Pelletier A, Bilodeau C, Grobs Y, Bourgeois A, Romanet C, Breuils-Bonnet S, Montesinos MS, Lu M, Chen H, Gilbert M, Théberge C, Potus F, Pullamsetti S, Provencher S, Bonnet S, Boucherat O
Cell reports. Medicine 2025 Feb 18;6(2):101964

Bavachinin exerts anti-tumor effects by activating TLR4/STING axis-dependent PANoptosis and synergistically enhances chemosensitivity in endometrial cancer.

Shu W, Chen G, Zhang J, Dong K, Zhou T, Cheng S, Zhang T, Zhang J, Li H, Yao Y, Yu S, Liu Y, Zhou X, Shen X, Wang H
Biochemical pharmacology 2025 Dec;242(Pt 2):117321

Inflammation Inhibits HECTD1-Mediated AURKA Ubiquitination to Cause Extracellular Matrix Degradation in Osteoarthritis via Enhancing Cap-Dependent mRNA Translation of ADAMTS12.

Xia D, Yu C, Zhou XP, Huang L, Yang S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70953

Vascular restenosis following paclitaxel-coated balloon therapy is attributable to NLRP3 activation and LIN9 upregulation.

Kan Q, Peng Z, Wang K, Deng T, Zhou Z, Wu R, Yao C, Wang R
Journal of translational medicine 2024 Sep 27;22(1):871

AURKA Enhances the Glycolysis and Development of Ovarian Endometriosis Through ERβ.

Sun Y, Zhang S, Zhang X, Li G, Sun F, Wang M, Ren C, Jiang A, Yang T
Endocrinology 2024 Feb 20;165(4)

Tabersonine enhances cisplatin sensitivity by modulating Aurora kinase A and suppressing epithelial-mesenchymal transition in triple-negative breast cancer.

Chen X, Yan Y, Liu Y, Yi Q, Xu Z
Pharmaceutical biology 2024 Dec;62(1):394-403

Adenovirus vaccine targeting kinases induces potent antitumor immunity in solid tumors.

Zhu F, Lu Z, Tang W, Zhao G, Shao Y, Lu B, Ding J, Zheng Y, Fang L, Li H, Wang G, Chen R, Zheng J, Chai D
Journal for immunotherapy of cancer 2024 Aug 28;12(8)

Cellular senescence-Related genes define the immune microenvironment and molecular characteristics in severe asthma patients.

Lin Q, Zheng Z, Ni H, Xu Y, Nie H
Gene 2024 Aug 15;919:148502

The kinesin motor Kif9 regulates centriolar satellite positioning and mitotic progression.

Vicente JJ, Wagenbach M, Decarreau J, Zelter A, MacCoss MJ, Davis TN, Wordeman L
bioRxiv : the preprint server for biology 2024 Apr 3;

Proliferation-associated 2G4 P48 is stabilized by malignant T-cell amplified sequence 1 and promotes the proliferation of head and neck squamous cell carcinoma.

Sun L, Xing G, Wang W, Ma X, Bu X
Journal of dental sciences 2023 Oct;18(4):1588-1597

Proteomics and phosphoproteomics of chordoma biopsies reveal alterations in multiple pathways and aberrant kinases activities.

Hang J, Ouyang H, Wei F, Zhong Q, Yuan W, Jiang L, Liu Z
Frontiers in oncology 2022;12:941046

Integrated Analysis of Transcriptome Data Revealed AURKA and KIF20A as Critical Genes in Medulloblastoma Progression.

Liang B, Zhou Y, Jiao J, Xu L, Yan Y, Wu Q, Tong X, Yan H
Frontiers in oncology 2022;12:875521

The Effect of Circumscribed Exposure to the Pan-Aurora Kinase Inhibitor VX-680 on Proliferating Euploid Cells.

Liu X, Shi Q, Choudhry N, Zhang T, Liu H, Zhang S, Zhang J, Yang D
International journal of molecular sciences 2022 Oct 11;23(20)

Bisphenol A-sulfate conjugate disrupts AURKA transcription and cell cycle in BeWo cytotrophoblasts.

Fujiki J, Uchida M, Tsunoda S, Maeda N, Inoue H, Yokota H, Iwano H
Molecular and cellular endocrinology 2022 Apr 5;545:111561

The Role of TRPC6 in Renal Ischemia/Reperfusion and Cellular Hypoxia/Reoxygenation Injuries.

Hou X, Huang M, Zeng X, Zhang Y, Sun A, Wu Q, Zhu L, Zhao H, Liao Y
Frontiers in molecular biosciences 2021;8:698975

Blocking AURKA with MK-5108 attenuates renal fibrosis in chronic kidney disease.

Jiang M, Bai M, Xu S, Wang T, Lei J, Xu M, Huang S, Jia Z, Zhang A
Biochimica et biophysica acta. Molecular basis of disease 2021 Nov 1;1867(11):166227

ARID3A promotes the development of colorectal cancer by upregulating AURKA.

Tang J, Yang L, Li Y, Ning X, Chaulagain A, Wang T, Wang D
Carcinogenesis 2021 Apr 30;42(4):578-586

PUF60/AURKA Axis Contributes to Tumor Progression and Malignant Phenotypes in Bladder Cancer.

Long Q, An X, Chen M, Wang N, Sui S, Li Y, Zhang C, Lee K, Wang X, Tian T, Pan Y, Qiu H, Xie F, Deng W, Zheng F, He L
Frontiers in oncology 2020;10:568015

Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.

Liu X, Zhang Y, Wu S, Xu M, Shen Y, Yu M, Fan J, Wei S, Xu C, Huang L, Zhao H, Li X, Ye X
Biochemical pharmacology 2020 May;175:113933

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