CPBT-56998RH

antibody from Creative Diagnostics

Targeting: RAF1 c-Raf, CRAF, Raf-1

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CPBT-56998RH

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#CPBT-56998RH, RRID:AB_2389852

Product name

Rabbit Anti-Human RAF1 Polyclonal antibody

Antibody type

Polyclonal

Description

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

Reactivity

Human, Mouse, Sheep

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

50 uL