66592-1-Ig

antibody from Proteintech Group

Targeting: RAF1 c-Raf, CRAF, Raf-1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66592-1-Ig

Provider

Proteintech Group

Product name

RAF1 antibody

Antibody type

Monoclonal

Description

KD/KO validated RAF1 antibody (Cat. #66592-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1D6A1

Vial size

20ul, 150ul

References

Submitted references

GLUD1 supports ovarian cancer progression by counteracting anoikis via ARAF/MEK/ERK signaling.

Feng H, Chen Y, Wu G, Zhang Z, Lai H, Yang C, Zhang S, Lin Y, Liu Y, Ye H, Wu S, Cao L
NPJ precision oncology 2026 Mar 5;10(1)

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NMB promotes the progression of colorectal cancer by regulating the NF-κB/P65 signaling pathway.

Fan J, Liu Y, Wang J, Yao T, Bai S, Ma X, Chen H, Chen Y, Gao H, Guo Y, Huang H
Frontiers in immunology 2025;16:1596451

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Nuclear force transmission drives cancer-associated fibroblast activation under BRAF inhibition.

Wang J, Soley BDS, Xiao Y, Siegfried LG, Zhou L, Xu M, Millar SE, Andl T, Zhang Y
bioRxiv : the preprint server for biology 2025 Sep 9;

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Natural Lignan Vitexin B-1 Induces Cell Cycle Arrest and Apoptosis via Targeting HSP90 Through EGFR Pathway in Non-Small Cell Lung Cancer.

Chen X, Lin X, Mo Y, Gan L, Huang Y, Gan B, Wang Z, Lin J, Zheng Y, Wang Z, Song X, Tu Z
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70598

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RAF1 in AgRP neurons involved in the regulation of energy metabolism via the MAPK signaling pathway.

Chen Y, Ren L, Xu X, Sun Z, Dai M, Li Y, Ma X, Li J
Journal of biomedical research 2025 May 28;40(1):45-62

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Pancreatic cancer-derived extracellular vesicles enhance chemoresistance by delivering KRAS(G12D) protein to cancer-associated fibroblasts.

Liu X, Yang J, Huang S, Hong Y, Zhu Y, Wang J, Wang Y, Liang T, Bai X
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Mar 5;33(3):1134-1153

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BRD9 promotes the malignant phenotype of thyroid cancer by activating the MAPK/ERK pathway.

Deng Y, Li Y, Cao H
Anti-cancer drugs 2025 Jun 1;36(5):359-373

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Bufalin inhibits hepatocellular carcinoma progression by blocking EGFR-mediated RAS-RAF-MEK-ERK pathway activation.

Liu J, Jiang J, Huang J, Fang ZE, Liu L, Liu Y, Nian W, Tang J, Wang Z
Journal of experimental & clinical cancer research : CR 2025 Aug 29;44(1):260

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Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.

Hu Y, Li Y, Xiong H, Zhang Y, Wang F, Zhuo W, Zeng Z, Zhao Y, Wang H, Hu P, Han S, Huang Y, Lv G, Zhao G
International journal of biological sciences 2024;20(11):4341-4363

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Vitamin D Relieves Epilepsy Symptoms and Neuroinflammation in Juvenile Mice by Activating the mTOR Signaling Pathway via RAF1: Insights from Network Pharmacology and Molecular Docking Studies.

Lu T, Chen X, Zhang Q, Shang K, Yang X, Xiang W
Neurochemical research 2024 Sep;49(9):2379-2392

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Oncogenic RTKs sensitize cancer cells to ferroptosis via c-Myc mediated upregulation of ACSL4.

Sun N, Wang J, Qin J, Ma S, Luan J, Hou G, Zhang W, Gao M
Cell death & disease 2024 Nov 27;15(11):861

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Integration analysis of cell division cycle-associated family genes revealed potential mechanisms of gliomagenesis and constructed an artificial intelligence-driven prognostic signature.

Yu K, Tian Q, Feng S, Zhang Y, Cheng Z, Li M, Zhu H, He J, Li M, Xiong X
Cellular signalling 2024 Jul;119:111168

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Sterigmatocystin declines mouse oocyte quality by inducing ferroptosis and asymmetric division defects.

Wang S, Wu X, Yang J, Peng Y, Miao F, Li M, Zeng J
Journal of ovarian research 2024 Aug 28;17(1):175

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TATA-box-binding protein-associated factor 15 is a novel biomarker that promotes cell proliferation and migration in gastrointestinal stromal tumor.

Guo CM, Tang L, Li X, Huang LY
World journal of gastroenterology 2023 May 21;29(19):2932-2949

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Tumor necrosis factor-like cytokine 1A plays a role in inflammatory bowel disease pathogenesis.

Meng F, Jiang X, Wang X, Zheng Q, Wang XN, Mei C, Yan S, He Y, Xue J, Zhang X, Fu W, You Y, Zhai J, Wang Y, Sun X
Proceedings of the National Academy of Sciences of the United States of America 2023 Aug 22;120(34):e2120771120

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TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1/MEK/ERK signalling pathway.

Tang L, Guo C, Li X, Zhang B, Huang L
Scientific reports 2023 Apr 10;13(1):5846

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Exosomal DNAJB11 promotes the development of pancreatic cancer by modulating the EGFR/MAPK pathway.

Liu P, Zu F, Chen H, Yin X, Tan X
Cellular & molecular biology letters 2022 Oct 8;27(1):87

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4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.

Li W, Huang BS, Xiong YY, Yang LJ, Wu LX
Cancer cell international 2022 Jan 18;22(1):32

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Lnc524369 promotes hepatocellular carcinoma progression and predicts poor survival by activating YWHAZ-RAF1 signaling.

Zheng W, Shen GL, Xu KY, Yin QQ, Hui TC, Zhou ZW, Xu CA, Wang SH, Wu WH, Shi LF, Pan HY
World journal of gastrointestinal oncology 2022 Jan 15;14(1):253-264

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Huai Qi Huang-induced Apoptosis via Down-regulating PRKCH and Inhibiting RAF/MEK/ERK Pathway in Ph(+) Leukemia Cells.

Xu WF, Wang ZJ, Li K, Shen YQ, Lu K, Lv XY, Wen YX, Jin RM
Current medical science 2020 Apr;40(2):354-362